Search Results - "Kaindl, Angela M."

Golgi-Cox Staining Step by Step by Zaqout, Sami, Kaindl, Angela M

“…Golgi staining remains a key method to study neuronal morphology in vivo. Since most protocols delineating modifications of the original staining method lack…”
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Immunofluorescence Staining of Paraffin Sections Step by Step by Zaqout, Sami, Becker, Lena-Luise, Kaindl, Angela M.

“…Immunofluorescence staining is the most frequently applied technique to detect and visualize various molecules in biological samples. Many protocols can be…”
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Neuronal death and oxidative stress in the developing brain by Ikonomidou, Chrysanthy, Kaindl, Angela M

“…The developing brain is particularly vulnerable to reactive oxygen and reactive nitrogen species-mediated damage because of its high concentrations of…”
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The yin and yang of microglia by Czeh, Melinda, Gressens, Pierre, Kaindl, Angela M

“…Microglia, the resident immune cells of the mammalian central nervous system (CNS), play a pivotal role in both physiological and pathological conditions such…”
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Diagnostic approach to microcephaly in childhood: a two‐center study and review of the literature by Hagen, Maja, Pivarcsi, Mark, Liebe, Juliane, Bernuth, Horst, Didonato, Nataliya, Hennermann, Julia B, Bührer, Christoph, Wieczorek, Dagmar, Kaindl, Angela M

“…Aim The aim of this study was to assess the diagnostic approach to microcephaly in childhood and to identify the prevalence of the various underlying…”
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Autosomal Recessive Primary Microcephaly: Not Just a Small Brain by Zaqout, Sami, Kaindl, Angela M

“…Microcephaly or reduced head circumference results from a multitude of abnormal developmental processes affecting brain growth and/or leading to brain atrophy…”
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Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system by Baxter, Paul S., Bell, Karen F.S., Hasel, Philip, Kaindl, Angela M., Fricker, Michael, Thomson, Derek, Cregan, Sean P., Gillingwater, Thomas H., Hardingham, Giles E.

“…How the brain’s antioxidant defenses adapt to changing demand is incompletely understood. Here we show that synaptic activity is coupled, via the NMDA receptor…”
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Subtelomeric methylation distinguishes between subtypes of Immunodeficiency, Centromeric instability and Facial anomalies syndrome by Toubiana, Shir, Velasco, Guillaume, Chityat, Adi, Kaindl, Angela M, Hershtig, Noam, Tzur-Gilat, Aya, Francastel, Claire, Selig, Sara

“…Abstract Human telomeres and adjacent subtelomeres are packaged as heterochromatin. Subtelomeric DNA undergoes methylation during development by DNA…”
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Corticosteroids in childhood epilepsies: A systematic review by Becker, Lena-Luise, Kaindl, Angela M

“…Corticosteroids have been used for the treatment of patients with epilepsy for more than 6 decades, based on the hypothesis of inflammation in the genesis…”
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What next-generation sequencing (NGS) technology has enabled us to learn about primary autosomal recessive microcephaly (MCPH) by Morris-Rosendahl, Deborah J., Kaindl, Angela M.

“…The impact that next-generation sequencing technology (NGS) is having on many aspects of molecular and cell biology, is becoming increasingly apparent. One of…”
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Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain by Kaindl, Angela M., Degos, Vincent, Peineau, Stéphane, Gouadon, Elodie, Chhor, Vibol, Loron, Gauthier, Le Charpentier, Tifenn, Josserand, Julien, Ali, Carine, Vivien, Denis, Collingridge, Graham L., Lombet, Alain, Issa, Lina, Rene, Frédérique, Loeffler, Jean-Philippe, Kavelaars, Annemieke, Verney, Catherine, Mantz, Jean, Gressens, Pierre

“…Objective: Activated microglia play a central role in the inflammatory and excitotoxic component of various acute and chronic neurological disorders. However,…”
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The clinical-phenotype continuum in DYNC1H1-related disorders—genomic profiling and proposal for a novel classification by Becker Lena-Luise, Salimi, Dafsari Hormos, Schallner Jens, Abdin Dalia, Seifert, Michael, Petit, Florence, Smol, Thomas, Bok Levinus, Rodan Lance, Krapels Ingrid, Spranger, Stephanie, Weschke Bernhard, Johnson, Katherine, Straub Volker, Kaindl, Angela M, Di Donato Nataliya, von der Hagen Maja, Cirak Sebahattin

“…Abstract Mutations in the cytoplasmic dynein 1 heavy chain gene ( DYNC1H1 ) have been identified in rare neuromuscular (NMD) and neurodevelopmental (NDD)…”
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Many roads lead to primary autosomal recessive microcephaly by Kaindl, Angela M, Passemard, Sandrine, Kumar, Pavan, Kraemer, Nadine, Issa, Lina, Zwirner, Angelika, Gerard, Benedicte, Verloes, Alain, Mani, Shyamala, Gressens, Pierre

“…Autosomal recessive primary microcephaly (MCPH), historically referred to as Microcephalia vera, is a genetically and clinically heterogeneous disease…”
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Abnormal brain structure and behavior in MyD88-deficient mice by Schroeder, Patricia, Rivalan, Marion, Zaqout, Sami, Krüger, Christina, Schüler, Jutta, Long, Melissa, Meisel, Andreas, Winter, York, Kaindl, Angela M., Lehnardt, Seija

“…•The central TLR/IL-1R signaling adaptor MyD88 modulates neocortical structure.•MyD88-deficiency affects neuronal branching.•MyD88 expression modulates mouse…”
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Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation by Hartmann, Bianca, Wai, Timothy, Hu, Hao, MacVicar, Thomas, Musante, Luciana, Fischer-Zirnsak, Björn, Stenzel, Werner, Gräf, Ralph, van den Heuvel, Lambert, Ropers, Hans-Hilger, Wienker, Thomas F, Hübner, Christoph, Langer, Thomas, Kaindl, Angela M

“…Mitochondriopathies often present clinically as multisystemic disorders of primarily high-energy consuming organs. Assembly, turnover, and surveillance of…”
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Treatment of pediatric convulsive status epilepticus by Becker, Lena-Luise, Gratopp, Alexander, Prager, Christine, Elger, Christian E, Kaindl, Angela M

“…Status epilepticus is one of the most common life-threatening neurological emergencies in childhood with the highest incidence in the first 5 years of life and…”
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A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing by Chen, Tao, Zhang, Bin, Ziegenhals, Thomas, Prusty, Archana B, Fröhler, Sebastian, Grimm, Clemens, Hu, Yuhui, Schaefke, Bernhard, Fang, Liang, Zhang, Min, Kraemer, Nadine, Kaindl, Angela M, Fischer, Utz, Chen, Wei

“…Malfunction of pre-mRNA processing factors are linked to several human diseases including cancer and neurodegeneration. Here we report the identification of a…”
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Real-World Experience Treating Pediatric Epilepsy Patients With Cenobamate by Makridis, Konstantin L., Bast, Thomas, Prager, Christine, Kovacevic-Preradovic, Tatjana, Bittigau, Petra, Mayer, Thomas, Breuer, Eva, Kaindl, Angela M.

“…Introduction In one third of all patients with epilepsy, seizure freedom is not achieved through anti-seizure medication (ASM). These patients have an…”
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Case report: Compound heterozygous NUP85 variants cause autosomal recessive primary microcephaly by Ravindran, Ethiraj, Lesca, Gaetan, Januel, Louis, Goldgruber, Linus, Dickmanns, Achim, Margot, Henri, Kaindl, Angela M

“…Nucleoporin (NUP) 85 is a member of the Y-complex of nuclear pore complex (NPC) that is key for nucleocytoplasmic transport function, regulation of mitosis,…”
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Sedative and anticonvulsant drugs suppress postnatal neurogenesis by Stefovska, Vanya G., Uckermann, Ortrud, Czuczwar, Miroslaw, Smitka, Martin, Czuczwar, Piotr, Kis, Jacek, Kaindl, Angela M., Turski, Lechoslaw, Turski, Waldemar A., Ikonomidou, Chrysanthy

“…Objective Sedative and anticonvulsant drugs, which inhibit N‐methyl‐D‐aspartate receptor–mediated excitation or enhance GABA‐mediated action, may cause…”
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