Search Results - "Kaidi, Abderrahmane"

Chromothripsis and cancer: causes and consequences of chromosome shattering by Forment, Josep V., Kaidi, Abderrahmane, Jackson, Stephen P.

“…Key Points Chromothripsis is a phenomenon by which tens to thousands of chromosomal rearrangements occur, with the available evidence indicating that…”
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A transient pool of nuclear F-actin at mitotic exit controls chromatin organization by Baarlink, Christian, Plessner, Matthias, Sherrard, Alice, Morita, Kohtaro, Misu, Shinji, Virant, David, Kleinschnitz, Eva-Maria, Harniman, Robert, Alibhai, Dominic, Baumeister, Stefan, Miyamoto, Kei, Endesfelder, Ulrike, Kaidi, Abderrahmane, Grosse, Robert

“…Re-establishment of nuclear structure and chromatin organization after cell division is integral for genome regulation or development and is frequently altered…”
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Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia by Kaidi, Abderrahmane, Qualtrough, David, Williams, Ann C, Paraskeva, Christos

“…Cyclooxygenase (COX)-2, the inducible key enzyme for prostanoid biosynthesis, is overexpressed in most colorectal carcinomas and a subset of colorectal…”
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Streamlined histone-based fluorescence lifetime imaging microscopy (FLIM) for studying chromatin organisation by Sherrard, Alice, Bishop, Paul, Panagi, Melanie, Villagomez, Maria Beatriz, Alibhai, Dominic, Kaidi, Abderrahmane

“…Changes in chromatin structure are key determinants of genomic responses. Thus, methods that enable such measurements are instrumental for investigating genome…”
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RETRACTED: Human SIRT6 promotes DNA end resection through CtIP deacetylation by Kaidi, Abderrahmane, Weinert, Brian T, Choudhary, Chunaram, Jackson, Stephen P

“…SIRT6 belongs to the sirtuin family of protein lysine deacetylases, which regulate aging and genome stability. We found that human SIRT6 has a role in…”
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Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia by Paraskeva, Christos, Kaidi, Abderrahmane, Williams, Ann Caroline

“…Aberrant activation of β-catenin promotes cell proliferation and initiates colorectal tumorigenesis. However, the expansion of tumours and the inadequacy of…”
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KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling by Kaidi, Abderrahmane, Jackson, Stephen P.

“…The detection of DNA lesions within chromatin represents a critical step in cellular responses to DNA damage. However, the regulatory mechanisms that couple…”
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Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation by Kaidi, Abderrahmane, Weinert, Brian T, Choudhary, Chunaram, Jackson, Stephen P

“…SIRT6 belongs to the sirtuin family of protein lysine deacetylases, which regulate aging and genome stability. We found that human SIRT6 has a role in…”
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Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4 by Polo, Sophie E, Kaidi, Abderrahmane, Baskcomb, Linda, Galanty, Yaron, Jackson, Stephen P

“…The chromatin remodelling factor chromodomain helicase DNA‐binding protein 4 (CHD4) is a catalytic subunit of the NuRD transcriptional repressor complex. Here,…”
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Retraction by Kaidi, Abderrahmane, Weinert, Brian T., Choudhary, Chunaram, Jackson, Stephen P.

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Retraction by Kaidi, Abderrahmane, Weinert, Brian T., Choudhary, Chunaram, Jackson, Stephen P.

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Retraction Note: KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling by Kaidi, Abderrahmane, Jackson, Stephen P.

“…This Article has been retracted; see accompanying Retraction…”
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The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment by Greenhough, Alexander, Smartt, Helena J.M., Moore, Amy E., Roberts, Heather R., Williams, Ann C., Paraskeva, Christos, Kaidi, Abderrahmane

“…It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the abundance of its enzymatic product prostaglandin E2 (PGE2) have key roles…”
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Tyrosine phosphorylation of KAT5 (Tip60) couples chromatin sensing to ATM-dependent checkpoint signaling by Kaidi, Abderrahmane, Jackson, Stephen P.

“…Detecting genomic changes represents a critical step in cellular responses to DNA damage. Here, we show that tyrosine phosphorylation of the protein…”
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The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis by Kollareddy, Madhu, Sherrard, Alice, Park, Ji Hyun, Szemes, Marianna, Gallacher, Kelli, Melegh, Zsombor, Oltean, Sebastian, Michaelis, Martin, Cinatl, Jindrich, Kaidi, Abderrahmane, Malik, Karim

“…Abstract Neuroblastoma is a biologically and clinically heterogeneous pediatric malignancy that includes a high-risk subset for which new therapeutic agents…”
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LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma by Vieira, Gabriella Cunha, Chockalingam, S, Melegh, Zsombor, Greenhough, Alexander, Malik, Sally, Szemes, Marianna, Park, Ji Hyun, Kaidi, Abderrahmane, Zhou, Li, Catchpoole, Daniel, Morgan, Rhys, Bates, David O, Gabb, Peter David, Malik, Karim

“…LGR5 is a marker of normal and cancer stem cells in various tissues where it functions as a receptor for R-spondins and increases canonical Wnt signalling…”
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Retraction by Kaidi, Abderrahmane, Weinert, Brian T, Choudhary, Chunaram, Jackson, Stephen P

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Retraction by Kaidi, Abderrahmane, Weinert, Brian T, Choudhary, Chunaram, Jackson, Stephen P

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Prostaglandin F 2 α stimulates motility and invasion in colorectal tumor cells by Qualtrough, David, Kaidi, Abderrahmane, Chell, Simon, Jabbour, Henry N., Williams, Ann C., Paraskeva, Christos

“…Abstract Increased expression of cyclooxygenase‐2 (COX‐2) and subsequent prostaglandin production is an important event in several human malignancies,…”
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Prostaglandin F2α stimulates motility and invasion in colorectal tumor cells by Qualtrough, David, Kaidi, Abderrahmane, Chell, Simon, Jabbour, Henry N., Williams, Ann C., Paraskeva, Christos

“…Increased expression of cyclooxygenase‐2 (COX‐2) and subsequent prostaglandin production is an important event in several human malignancies, including…”
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