Search Results - "Kaibuchi, Kozo"

Neuronal polarity: from extracellular signals to intracellular mechanisms by Kaibuchi, Kozo, Arimura, Nariko

“…After they are born and differentiate, neurons break their previous symmetry, dramatically change their shape, and establish two structurally and functionally…”
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Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity by Amano, Mutsuki, Nakayama, Masanori, Kaibuchi, Kozo

“…Rho‐associated kinase (Rho‐kinase/ROCK/ROK) is an effector of the small GTPase Rho and belongs to the AGC family of kinases. Rho‐kinase has pleiotropic…”
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Regulation of neuronal migration, an emerging topic in autism spectrum disorders by Reiner, Orly, Karzbrun, Eyal, Kshirsagar, Aditya, Kaibuchi, Kozo

“…Autism spectrum disorders (ASD) encompass a group of neurodevelopmental diseases that demonstrate strong heritability, however, the inheritance is not simple…”
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Neuronal polarization by Takano, Tetsuya, Xu, Chundi, Funahashi, Yasuhiro, Namba, Takashi, Kaibuchi, Kozo

“…Neurons are highly polarized cells with structurally and functionally distinct processes called axons and dendrites. This polarization underlies the…”
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IQGAPs as Key Regulators of Actin-cytoskeleton Dynamics by Watanabe, Takashi, Wang, Shujie, Kaibuchi, Kozo

“…The actin-cytoskeleton plays a critical role in various biological processes, including cell migration, development, tissue remodeling, and memory formation…”
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Protein kinases phosphorylate long disordered regions in intrinsically disordered proteins by Koike, Ryotaro, Amano, Mutsuki, Kaibuchi, Kozo, Ota, Motonori

“…Phosphorylation is a major post‐translational modification that plays a central role in signaling pathways. Protein kinases phosphorylate substrates…”
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Neuromodulator regulation and emotions: insights from the crosstalk of cell signaling by Tsuboi, Daisuke, Nagai, Taku, Yoshimoto, Junichiro, Kaibuchi, Kozo

“…The unraveling of the regulatory mechanisms that govern neuronal excitability is a major challenge for neuroscientists worldwide. Neurotransmitters play a…”
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Phosphorylation Signals in Striatal Medium Spiny Neurons by Nagai, Taku, Yoshimoto, Junichiro, Kannon, Takayuki, Kuroda, Keisuke, Kaibuchi, Kozo

“…Dopamine signaling in the brain is a complex phenomenon that strongly contributes to emotional behaviors. Medium spiny neurons (MSNs) play a major role in…”
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Extracellular and Intracellular Signaling for Neuronal Polarity by Namba, Takashi, Funahashi, Yasuhiro, Nakamuta, Shinichi, Xu, Chundi, Takano, Tetsuya, Kaibuchi, Kozo

“…Neurons are one of the highly polarized cells in the body. One of the fundamental issues in neuroscience is how neurons establish their polarity; therefore,…”
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The Evaluation of Rac1 Signaling as a Potential Therapeutic Target of Alzheimer's Disease by Wang, Huanhuan, Yamahashi, Yukie, Riedl, Marcel, Amano, Mutsuki, Kaibuchi, Kozo

“…The Small GTPase Rac1 is critical for various fundamental cellular processes, including cognitive functions. The cyclical activation and inactivation of Rac1,…”
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Synaptic dysregulation in a human iPS cell model of mental disorders by Wen, Zhexing, Nguyen, Ha Nam, Guo, Ziyuan, Lalli, Matthew A., Wang, Xinyuan, Su, Yijing, Kim, Nam-Shik, Yoon, Ki-Jun, Shin, Jaehoon, Zhang, Ce, Makri, Georgia, Nauen, David, Yu, Huimei, Guzman, Elmer, Chiang, Cheng-Hsuan, Yoritomo, Nadine, Kaibuchi, Kozo, Zou, Jizhong, Christian, Kimberly M., Cheng, Linzhao, Ross, Christopher A., Margolis, Russell L., Chen, Gong, Kosik, Kenneth S., Song, Hongjun, Ming, Guo-li

“…Generation and neural differentiation of induced pluripotent stem cells (iPS cells) from patients enables new ways to investigate the cellular pathophysiology…”
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LRRK1 phosphorylation of Rab7 at S72 links trafficking of EGFR-containing endosomes to its effector RILP by Hanafusa, Hiroshi, Yagi, Takuya, Ikeda, Haruka, Hisamoto, Naoki, Nishioka, Tomoki, Kaibuchi, Kozo, Shirakabe, Kyoko, Matsumoto, Kunihiro

“…Ligand-induced activation of epidermal growth factor receptor (EGFR) initiates trafficking events that re-localize the receptor from the cell surface to…”
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Radial Glial Cell-Neuron Interaction Directs Axon Formation at the Opposite Side of the Neuron from the Contact Site by Xu, Chundi, Funahashi, Yasuhiro, Watanabe, Takashi, Takano, Tetsuya, Nakamuta, Shinichi, Namba, Takashi, Kaibuchi, Kozo

“…How extracellular cues direct axon-dendrite polarization in mouse developing neurons is not fully understood. Here, we report that the radial glial cell…”
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Neuronal Polarity: Positive and Negative Feedback Signals by Takano, Tetsuya, Funahashi, Yasuhiro, Kaibuchi, Kozo

“…Establishment and maintenance of neuronal polarity are critical for neuronal development and function. One of the fundamental questions in neurodevelopment is…”
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Spatial regulation of VEGF receptor endocytosis in angiogenesis by Nakayama, Masanori, Nakayama, Akiko, van Lessen, Max, Yamamoto, Hiroyuki, Hoffmann, Sarah, Drexler, Hannes C. A., Itoh, Norimichi, Hirose, Tomonori, Breier, Georg, Vestweber, Dietmar, Cooper, Jonathan A., Ohno, Shigeo, Kaibuchi, Kozo, Adams, Ralf H.

“…Activities as diverse as migration, proliferation and patterning occur simultaneously and in a coordinated fashion during tissue morphogenesis. In the growing…”
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Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in striatal medium spiny neurons by Zhang, Xinjian, Nagai, Taku, Ahammad, Rijwan Uddin, Kuroda, Keisuke, Nakamuta, Shinichi, Nakano, Takashi, Yukinawa, Naoto, Funahashi, Yasuhiro, Yamahashi, Yukie, Amano, Mutsuki, Yoshimoto, Junichiro, Yamada, Kiyofumi, Kaibuchi, Kozo

“…Medium spiny neurons (MSNs) expressing dopamine D1 receptor (D1R) or D2 receptor (D2R) are major components of the striatum. Stimulation of D1R activates…”
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Phosphorylation Signals Downstream of Dopamine Receptors in Emotional Behaviors: Association with Preference and Avoidance by Zhang, Xinjian, Tsuboi, Daisuke, Funahashi, Yasuhiro, Yamahashi, Yukie, Kaibuchi, Kozo, Nagai, Taku

“…Dopamine regulates emotional behaviors, including rewarding and aversive behaviors, through the mesolimbic dopaminergic pathway, which projects dopamine…”
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Phosphorylation of Gephyrin in Zebrafish Mauthner Cells Governs Glycine Receptor Clustering and Behavioral Desensitization to Sound by Ogino, Kazutoyo, Yamada, Kenta, Nishioka, Tomoki, Oda, Yoichi, Kaibuchi, Kozo, Hirata, Hiromi

“…The process by which future behavioral responses are shaped by past experiences is one of the central questions in neuroscience. To gain insight into this…”
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Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK by Ariza, Anthony, Funahashi, Yasuhiro, Kozawa, Sachi, Omar Faruk, Md, Nagai, Taku, Amano, Mutsuki, Kaibuchi, Kozo

“…Dopamine type 1 receptor (D1R) signaling activates protein kinase A (PKA), which then activates mitogen‐activated protein kinase (MAPK) through Rap1, in…”
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Discovery of long-range inhibitory signaling to ensure single axon formation by Takano, Tetsuya, Wu, Mengya, Nakamuta, Shinichi, Naoki, Honda, Ishizawa, Naruki, Namba, Takashi, Watanabe, Takashi, Xu, Chundi, Hamaguchi, Tomonari, Yura, Yoshimitsu, Amano, Mutsuki, Hahn, Klaus M., Kaibuchi, Kozo

“…A long-standing question in neurodevelopment is how neurons develop a single axon and multiple dendrites from common immature neurites. Long-range inhibitory…”
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