Search Results - "Kaibara, A"

Proarrhythmic Safety of Repeat Doses of Mirabegron in Healthy Subjects: A Randomized, Double-Blind, Placebo-, and Active-Controlled Thorough QT Study by Malik, M, van Gelderen, E M, Lee, J H, Kowalski, D L, Yen, M, Goldwater, R, Mujais, S K, Schaddelee, M P, de Koning, P, Kaibara, A, Moy, S S, Keirns, J J

“…Potential effects of the selective β3‐adrenoceptor agonist mirabegron on cardiac repolarization were studied in healthy subjects. The four‐arm, parallel,…”
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A Phase 1, Randomized Ascending Single‐Dose Study of Antagonist Anti‐Human CD40 ASKP1240 in Healthy Subjects by Goldwater, R., Keirns, J., Blahunka, P., First, R., Sawamoto, T., Zhang, W., Kowalski, D., Kaibara, A., Holman, J.

“…This first‐in‐human, phase I study evaluated the safety, tolerability, pharmacokinetic and pharmacodynamic profile of ASKP1240 in healthy subjects. Twelve…”
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Guidelines for the Quality Control of Population Pharmacokinetic–Pharmacodynamic Analyses: an Industry Perspective by Bonate, P. L., Strougo, A., Desai, A., Roy, M., Yassen, A., van der Walt, J. S., Kaibara, A., Tannenbaum, S.

“…Quality population modeling and simulation analyses and reports are something every modeler desires. However, little attention in the literature has been paid…”
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Effect of surgical stress on endogenous morphine and cytokine levels in the plasma after laparoscopoic or open cholecystectomy by YOSHIDA, S, OHTA, J, YAMASAKI, K, KAMEI, H, HARADA, Y, YAHARA, T, KAIBARA, A, OZAKI, K, TAJIRI, T, SHIROUZU, K

“…Endogenous morphine in the brain leads to various biological responses after surgery. The aim of this study was to determine whether morphine levels in the…”
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Anorectic Effects of the Cytokine, Ciliary Neurotropic Factor, Are Mediated by Hypothalamic Neuropeptide Y: Comparison with Leptin by Xu, B., Dube, M. G., Kalra, P. S., Farmerie, W. G., Kaibara, A., Moldawer, L. L., Martin, D., Kalra, S. P.

“…Abstract Although ciliary neurotropic factor (CNTF) is a tropic factor in nervous system development and maintenance, peripheral administration of this…”
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Endoscopic decompression procedure in acute obstructing colorectal cancer by Araki, Y, Isomoto, H, Matsumoto, A, Kaibara, A, Yasunaga, M, Hayashi, K, Yatsugi, H, Yamauchi, K

“…In the treatment of acute obstructing colorectal cancer, a nasoenteric ileus tube is not capable of providing sufficient decompression of the enlarged…”
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Effect of glutamine and chemotherapy on protein metabolism in tumor-bearing rats by Kaibara, A, Yoshida, S, Yamasaki, K, Ishibashi, N, Kakegawa, T

“…Supplemental glutamine prevents gut atrophy and enhances muscle protein synthesis in septic rats. This study investigated the effect of glutamine…”
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Effect of Glutamine Supplementation on Protein Metabolism and Glutathione in Tumor-Bearing Rats by Yoshida, Shogo, Kaibara, Atsushi, Yamasaki, Kokushi, Ishibashi, Nobuya, Noake, Toshihiro, Kakegawa, Teruo

“…Background: Since tumor-bearing rats are deficient in glutamine, we investigated whether (1) glutamine and glutathione deficiency occur in tumor-bearing rats,…”
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Retention characteristics of octadecylsilyl silica, trimethylsilyl silica and phenyldimethylsilyl silica in reversed-phase liquid chromatography by Kaibara, A., Hirose, M., Nakagawa, T.

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Evaluation of solute hydrophobicity by reversed-phase high performance liquid chromatography using aqueous binary mobile phases by Kaibara, A., Hohda, C., Hirata, N., Hirose, M., Nakagawa, T.

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Effect of the polar functional group of the solute on hydrophobic interaction with the stationary ligand in reversed-phase high-performance liquid chromatography by KAIBARA, A, HIROSE, M, NAKAGAWA, T

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Glutamine supplementation in cancer patients by Yoshida, Shogo, Kaibara, Atsushi, Ishibashi, Nobuya, Shirouzu, Kazuo

“…OBJECTIVES: Three series of studies investigated whether 1) glutamine deficiency occurs in tumor-bearing rats, 2) glutamine supplementation improves protein…”
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Glutamine (Gln) supplementation in septic rats by Yoshida, S, Yamasaki, K, Kaibara, A, Mizote, H, Kakegawa, T

“…The objectives of these experiments were to investigate the effect of Gln supplementation on protein metabolism and immune function in septic rats. (Experiment…”
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GPX1 knockout reduces the cytokine response and prevents liver injury through induction of HSP70 after 70% partial hepatectomy by Oka, Y., Iwakuma, N., Kaibara, A., Ishibashi, N., Shirouzu, K.

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Effect of preoperative administration of methylprednisone on bloodstream tumor cell metastasis after surgical stress by Ishibashi, N., Momosaki, K., Oka, Y., Iwakuma, N., Kaibara, A., Shirouzu, K.

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Involvement of 26-kDa cell-associated TNF-alpha in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor by Solorzano, CC, Ksontini, R, Pruitt, JH, Hess, PJ, Edwards, PD, Kaibara, A, Abouhamze, A, Auffenberg, T, Galardy, RE, Vauthey, JN, Copeland, EM, 3rd, Edwards, CK, 3rd, Lauwers, GY, Clare-Salzler, M, MacKay, SL, Moldawer, LL, Lazarus, DD

“…TNF-alpha is a pleiotropic cytokine that exists both as a 26-kDa cell-associated and a 17-kDa soluble form. Recently, a class of matrix metalloproteinase…”
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Leptin produces anorexia and weight loss without inducing an acute phase response or protein wasting by Kaibara, A, Moshyedi, A, Auffenberg, T, Abouhamze, A, Copeland, E.M. III, Kalra, S, Moldawer, L.L

“…The ob gene product leptin is known to produce anorexia and loss of body fat when chronically administered to both lean and genetically obese mice. The current…”
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A human tumor necrosis factor p75 receptor agonist stimulates in vitro T cell proliferation but does not produce inflammation or shock in the baboon by Welborn, 3rd, M B, Van Zee, K, Edwards, P D, Pruitt, J H, Kaibara, A, Vauthey, J N, Rogy, M, Castleman, W L, Lowry, S F, Kenney, J S, Stüber, D, Ettlin, U, Wipf, B, Loetscher, H, Copeland, 3rd, E M, Lesslauer, W, Moldawer, L L

“…Tumor necrosis factor (TNF) is a potentially useful adjunct to anticancer therapies. However, the clinical utility of TNF has been limited by generalized…”
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P.98 Central nervous system regulates mucosal proteinturnover via cytokine by Yoshida, S., Yoshizumi, T., Shirouzu, Y., Kaibara, A., Yamasaki, K., Kamei, H., Ozaki, K., Shirouzu, K.

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Pharmacokinetics, immunogenicity, and efficacy of dimeric TNFR binding proteins in healthy and bacteremic baboon by Solorzano, Carmen C, Kaibara, Atsushi, Hess, Phillip J, Edwards, Paul D, Ksontini, Riadh, Abouhamze, Amer, McDaniel, Sherry, Frazier, Janet, Trujillo, Deborah, Kieft, Gary, Seely, James, Kohno, Tadahiko, Cosenza, Mary Ellen, Clare-Salzler, Michael, MacKay, Sally L. D, Martin, Steven W, Moldawer, Lyle L, Edwards, Carl K., III

“…1  Departments of Surgery and 3  Pathology, University of Florida College of Medicine, Gainesville, Florida 32610; 2  Amgen, Inc., Boulder, Colorado 80301; and…”
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