Search Results - "Kai, Marc P."

PEGylated PRINT Nanoparticles: The Impact of PEG Density on Protein Binding, Macrophage Association, Biodistribution, and Pharmacokinetics by Perry, Jillian L, Reuter, Kevin G, Kai, Marc P, Herlihy, Kevin P, Jones, Stephen W, Luft, J. Chris, Napier, Mary, Bear, James E, DeSimone, Joseph M

“…In this account, we varied PEGylation density on the surface of hydrogel PRINT nanoparticles and systematically observed the effects on protein adsorption,…”
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Nanoparticle surface charge impacts distribution, uptake and lymph node trafficking by pulmonary antigen-presenting cells by Fromen, Catherine A., PhD, Rahhal, Tojan B., BS, Robbins, Gregory R., PhD, Kai, Marc P., PhD, Shen, Tammy W., PhD, Luft, J. Christopher, PhD, DeSimone, Joseph M., PhD

“…Abstract Engineered nanoparticles have the potential to expand the breadth of pulmonary therapeutics, especially as respiratory vaccines. Notably, cationic…”
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Controlled analysis of nanoparticle charge on mucosal and systemic antibody responses following pulmonary immunization by Fromen, Catherine A., Robbins, Gregory R., Shen, Tammy W., Kai, Marc P., Ting, Jenny P. Y., DeSimone, Joseph M.

“…Significance To our knowledge, no other nano-based vaccine delivery platform has directly assessed the effects of nanoparticle charge on pulmonary vaccination…”
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Nanoparticle clearance is governed by Th1/Th2 immunity and strain background by Jones, Stephen W, Roberts, Reid A, Robbins, Gregory R, Perry, Jillian L, Kai, Marc P, Chen, Kai, Bo, Tao, Napier, Mary E, Ting, Jenny P Y, Desimone, Joseph M, Bear, James E

“…Extended circulation of nanoparticles in blood is essential for most clinical applications. Nanoparticles are rapidly cleared by cells of the mononuclear…”
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Biodistribution and Toxicity of Micellar Platinum Nanoparticles in Mice via Intravenous Administration by Brown, Anna L, Kai, Marc P, DuRoss, Allison N, Sahay, Gaurav, Sun, Conroy

“…Platinum nanoparticles (PtNPs) have shown promise as diagnostic and therapeutic agents due to their unique physiochemical properties. However, critical…”
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Tumor Presence Induces Global Immune Changes and Enhances Nanoparticle Clearance by Kai, Marc P, Brighton, Hailey E, Fromen, Catherine A, Shen, Tammy W, Luft, J. Christopher, Luft, Yancey E, Keeler, Amanda W, Robbins, Gregory R, Ting, Jenny P. Y, Zamboni, William C, Bear, James E, DeSimone, Joseph M

“…Long-circulating nanoparticles are essential for increasing tumor accumulation to provide therapeutic efficacy. While it is known that tumor presence can alter…”
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Distribution and Cellular Uptake of PEGylated Polymeric Particles in the Lung Towards Cell-Specific Targeted Delivery by Shen, Tammy W., Fromen, Catherine A., Kai, Marc P., Luft, J. Christopher, Rahhal, Tojan B., Robbins, Gregory R., DeSimone, Joseph M.

“…Purpose We evaluated the role of a poly(ethylene glycol) (PEG) surface coating to increase residence times and alter the cellular fate of nano- and…”
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Evaluation of drug loading, pharmacokinetic behavior, and toxicity of a cisplatin-containing hydrogel nanoparticle by Kai, Marc P., Keeler, Amanda W., Perry, Jillian L., Reuter, Kevin G., Luft, J. Christopher, O'Neal, Sara K., Zamboni, William C., DeSimone, Joseph M.

“…Cisplatin is a cytotoxic drug used as a first-line therapy for a wide variety of cancers. However, significant renal and neurological toxicities limit its…”
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Pulmonary Delivery of Butyrylcholinesterase as a Model Protein to the Lung by Rahhal, Tojan B, Fromen, Catherine A, Wilson, Erin M, Kai, Marc P, Shen, Tammy W, Luft, J. Christopher, DeSimone, Joseph M

“…Pulmonary delivery has great potential for delivering biologics to the lung if the challenges of maintaining activity, stability, and ideal aerosol…”
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Calibration-quality cancer nanotherapeutics by Perry, Jillian L, Kai, Marc P, Reuter, Kevin G, Bowerman, Charles, Christopher Luft, J, DeSimone, Joseph M

“…Nanoparticle properties such as size, shape, deformability, and surface chemistry all play a role in nanomedicine drug delivery in cancer. While many studies…”
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