Search Results - "Kahyo, Tomoaki"

Prognostic impact of CD73 and A2A adenosine receptor expression in non-small-cell lung cancer by Inoue, Yusuke, Yoshimura, Katsuhiro, Kurabe, Nobuya, Kahyo, Tomoaki, Kawase, Akikazu, Tanahashi, Masayuki, Ogawa, Hiroshi, Inui, Naoki, Funai, Kazuhito, Shinmura, Kazuya, Niwa, Hiroshi, Suda, Takafumi, Sugimura, Haruhiko

“…In immune cells, CD73 dephosphorylates and converts extracellular AMP into adenosine, which binds the A2A adenosine receptor (A2AR). Blockade of this…”
Get full text

Hypertrophy of the ligamentum flavum in lumbar spinal canal stenosis is associated with abnormal accumulation of specific lipids by Yamada, Tomohiro, Horikawa, Makoto, Sato, Tomohito, Kahyo, Tomoaki, Takanashi, Yusuke, Ushirozako, Hiroki, Kurosu, Kenta, Al Mamun, Md, Mihara, Yuki, Oe, Shin, Arima, Hideyuki, Banno, Tomohiro, Yosida, Go, Hasegawa, Tomohiko, Yamato, Yu, Matsuyama, Yukihiro, Setou, Mitsutoshi

“…Ligamentum flavum hypertrophy (HLF) is the most important component of lumbar spinal canal stenosis (LSCS). Analysis of hypertrophied ligamentum flavum (HLF)…”
Get full text

Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway by Ota, Hidetaka, Eto, Masato, Kano, Mitsunobu R, Kahyo, Tomoaki, Setou, Mitsutoshi, Ogawa, Sumito, Iijima, Katsuya, Akishita, Masahiro, Ouchi, Yasuyoshi

“…OBJECTIVE—Statins (3-hydroxy-3-methylglutaryl–coenzyme A reductase inhibitors) have pleiotropic vascular protective effects besides cholesterol lowering…”
Get full text

Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4 by Kurabe, Nobuya, Hayasaka, Takahiro, Ogawa, Mikako, Masaki, Noritaka, Ide, Yoshimi, Waki, Michihiko, Nakamura, Toshio, Kurachi, Kiyotaka, Kahyo, Tomoaki, Shinmura, Kazuya, Midorikawa, Yutaka, Sugiyama, Yasuyuki, Setou, Mitsutoshi, Sugimura, Haruhiko

“…The identification of cancer biomarkers is critical for target‐linked cancer therapy. The overall level of phosphatidylcholine (PC) is elevated in colorectal…”
Get full text

Clinical significance of PD-L1 and PD-L2 copy number gains in non-small-cell lung cancer by Inoue, Yusuke, Yoshimura, Katsuhiro, Mori, Kazutaka, Kurabe, Nobuya, Kahyo, Tomoaki, Mori, Hiroki, Kawase, Akikazu, Tanahashi, Masayuki, Ogawa, Hiroshi, Inui, Naoki, Funai, Kazuhito, Shinmura, Kazuya, Niwa, Hiroshi, Suda, Takafumi, Sugimura, Haruhiko

“…New reliable biomarkers are needed to predict the response to immune checkpoint inhibitors against programmed death-1 (PD-1) and its ligand (PD-L1), because…”
Get full text

Prognostic potential of lipid profiling in cancer patients: a systematic review of mass spectrometry-based studies by Takanashi, Yusuke, Kahyo, Tomoaki, Sekihara, Keigo, Kawase, Akikazu, Setou, Mitsutoshi, Funai, Kazuhito

“…Cancer prognosis remains a critical clinical challenge. Lipidomic analysis via mass spectrometry (MS) offers the potential for objective prognostic prediction,…”
Get full text

UBL3 modification influences protein sorting to small extracellular vesicles by Ageta, Hiroshi, Ageta-Ishihara, Natsumi, Hitachi, Keisuke, Karayel, Ozge, Onouchi, Takanori, Yamaguchi, Hisateru, Kahyo, Tomoaki, Hatanaka, Ken, Ikegami, Koji, Yoshioka, Yusuke, Nakamura, Kenji, Kosaka, Nobuyoshi, Nakatani, Masashi, Uezumi, Akiyoshi, Ide, Tomihiko, Tsutsumi, Yutaka, Sugimura, Haruhiko, Kinoshita, Makoto, Ochiya, Takahiro, Mann, Matthias, Setou, Mitsutoshi, Tsuchida, Kunihiro

“…Exosomes, a type of small extracellular vesicles (sEVs), derived from multivesicular bodies (MVBs), mediate cell-to-cell communication by transporting…”
Get full text

Spatial distribution of the Shannon entropy for mass spectrometry imaging by Xu, Lili, Kikushima, Kenji, Sato, Shumpei, Islam, Ariful, Sato, Tomohito, Aramaki, Shuhei, Zhang, Chi, Sakamoto, Takumi, Eto, Fumihiro, Takahashi, Yutaka, Yao, Ikuko, Machida, Manabu, Kahyo, Tomoaki, Setou, Mitsutoshi

“…Mass spectrometry imaging (MSI) allows us to visualize the spatial distribution of molecular components in a sample. A large amount of mass spectrometry data…”
Get full text

Editorial Comment on Validation of the digital PCR system for use in tyrosine kinase inhibitor‐resistant EGFR‐mutant non‐small‐cell lung cancer by Sugimura, Haruhiko, Kahyo, Tomoaki

Get full text

Cinnamomum verum J. Presl Bark Contains High Contents of Nicotinamide Mononucleotide by Yan, Jing, Sakamoto, Takumi, Islam, Ariful, Ping, Yashuang, Oyama, Soho, Fuchino, Hiroyuki, Kawakami, Hitomi, Yoshimatsu, Kayo, Kahyo, Tomoaki, Setou, Mitsutoshi

“…The global population is aging, and intervention strategies for anti-aging and the prevention of aging-related diseases have become a topic actively explored…”
Get full text

Heterogeneity analysis of PD-L1 expression and copy number status in EBUS-TBNA biopsy specimens of non-small cell lung cancer: Comparative assessment of primary and metastatic sites by Yoshimura, Katsuhiro, Inoue, Yusuke, Karayama, Masato, Tsuchiya, Kazuo, Mori, Kazutaka, Suzuki, Yuzo, Iwashita, Yuji, Kahyo, Tomoaki, Kawase, Akikazu, Tanahashi, Masayuki, Ogawa, Hiroshi, Yokomura, Koushi, Inui, Naoki, Funai, Kazuhito, Shinmura, Kazuya, Niwa, Hiroshi, Suda, Takafumi, Sugimura, Haruhiko

“…•Moderate concordance of PD-L1 expression between EBUS-TBNA and other specimens.•Comparable concordance between PD-L1 copy number alterations and PD-L1…”
Get full text

Lung adenocarcinoma and squamous cell carcinoma difficult for immunohistochemical diagnosis can be distinguished by lipid profile by Yamashita, Takashi, Takanashi, Yusuke, Uebayashi, Asuka, Oka, Mikako, Mizuno, Kiyomichi, Kawase, Akikazu, Oyama, Soho, Kitamoto, Takuya, Kondo, Minako, Omori, Shiho, Tao, Hong, Takahashi, Yutaka, Sakamoto, Takumi, Kahyo, Tomoaki, Sugimura, Haruhiko, Setou, Mitsutoshi, Shiiya, Norihiko, Funai, Kazuhito

“…In patients with unresectable non-small cell lung cancer, histological diagnosis is frequently based on small biopsy specimens unsuitable for histological…”
Get full text

Sphingomyelin(d35:1) as a novel predictor for lung adenocarcinoma recurrence after a radical surgery: a case-control study by Takanashi, Yusuke, Funai, Kazuhito, Sato, Shumpei, Kawase, Akikazu, Tao, Hong, Takahashi, Yutaka, Sugimura, Haruhiko, Setou, Mitsutoshi, Kahyo, Tomoaki, Shiiya, Norihiko

“…To improve the postoperative prognosis of patients with lung cancer, predicting the recurrence high-risk patients is needed for the efficient application of…”
Get full text

Lipidomics-based tissue heterogeneity in specimens of luminal breast cancer revealed by clustering analysis of mass spectrometry imaging: A preliminary study by Aramaki, Shuhei, Tsuge, Shogo, Islam, Ariful, Eto, Fumihiro, Sakamoto, Takumi, Oyama, Soho, Li, Wenxin, Zhang, Chi, Yamaguchi, Shinichi, Takatsuka, Daiki, Hosokawa, Yuko, Waliullah, A S M, Takahashi, Yutaka, Kikushima, Kenji, Sato, Tomohito, Koizumi, Kei, Ogura, Hiroyuki, Kahyo, Tomoaki, Baba, Satoshi, Shiiya, Norihiko, Sugimura, Haruhiko, Nakamura, Katsumasa, Setou, Mitsutoshi

“…Cancer tissues reflect a greater number of pathological characteristics of cancer compared to cancer cells, so the evaluation of cancer tissues can be…”
Get full text

Alpha-Synuclein Interaction with UBL3 Is Upregulated by Microsomal Glutathione S-Transferase 3, Leading to Increased Extracellular Transport of the Alpha-Synuclein under Oxidative Stress by Yan, Jing, Kahyo, Tomoaki, Zhang, Hengsen, Ping, Yashuang, Zhang, Chi, Jiang, Shuyun, Ji, Qianqing, Ferdous, Rafia, Islam, Md Shoriful, Oyama, Soho, Aramaki, Shuhei, Sato, Tomohito, Mimi, Mst Afsana, Hasan, Md Mahmudul, Setou, Mitsutoshi

“…Aberrant aggregation of misfolded alpha-synuclein (α-syn), a major pathological hallmark of related neurodegenerative diseases such as Parkinson's disease…”
Get full text

Mass Spectrometry Imaging Combined with Sparse Autoencoder Method Reveals Altered Phosphorylcholine Distribution in Imipramine Treated Wild-Type Mice Brains by Rahman, Md Foyzur, Islam, Ariful, Islam, Md Monirul, Mamun, Md Al, Xu, Lili, Sakamoto, Takumi, Sato, Tomohito, Takahashi, Yutaka, Kahyo, Tomoaki, Aoyagi, Satoka, Kaibuchi, Kozo, Setou, Mitsutoshi

“…Mass spectrometry imaging (MSI) is essential for visualizing drug distribution, metabolites, and significant biomolecules in pharmacokinetic studies. This…”
Get full text

Elucidating Gender-Specific Distribution of Imipramine, Chloroquine, and Their Metabolites in Mice Kidney Tissues through AP-MALDI-MSI by Islam, Md Monirul, Rahman, Md Foyzur, Islam, Ariful, Afroz, Mst Sayela, Mamun, Md Al, Rahman, Md Muedur, Maniruzzaman, Md, Xu, Lili, Sakamoto, Takumi, Takahashi, Yutaka, Sato, Tomohito, Kahyo, Tomoaki, Setou, Mitsutoshi

“…Knowledge of gender-specific drug distributions in different organs are of great importance for personalized medicine and reducing toxicity. However, such drug…”
Get full text

Ubiquitin-like 3 as a new protein-sorting factor for small extracellular vesicles by Takanashi, Yusuke, Kahyo, Tomoaki, Kamamoto, Sae, Zhang, Hengsen, Chen, Bin, Ping, Yashuang, Mizuno, Kiyomichi, Kawase, Akikazu, Koizumi, Kei, Satou, Masanori, Funai, Kazuhito, Shiiya, Norihiko, Setou, Mitsutoshi

“…Ubiquitin-like 3 (UBL3) is a well-conserved ubiquitin-like protein (UBL) in eukaryotes and regulates the ubiquitin cascade, but the significant roles of UBL3…”
Get full text

Glutaraldehyde and uranyl acetate dual fixation combined sputtering/unroofing enables intracellular fatty acids TOF-SIMS imaging with organelle-corresponding subcellular distribution by Zhang, Chi, Horikawa, Makoto, Kahyo, Tomoaki, Matsudaira, Takaomi, Tanaka, Tatsuya, Xu, Lili, Takei, Shiro, Setou, Mitsutoshi

“…Fatty acids (FAs) have diverse functions in cellular activities. The intracellular distribution of FAs is critical for their functions. Imaging of FAs by…”
Get full text

Lipid Polyunsaturated Fatty Acid Chains in Mouse Kidneys Were Increased within 5 min of a Single High Dose Whole Body Irradiation by Li, Wenxin, Zhang, Chi, Aramaki, Shuhei, Xu, Lili, Tsuge, Shogo, Sakamoto, Takumi, Mamun, Md Al, Islam, Ariful, Hayakawa, Takamitsu, Takanashi, Yusuke, Dubail, Maxime, Konishi, Kenta, Sato, Tomohito, Kahyo, Tomoaki, Fouillade, Charles, Nakamura, Katsumasa, Setou, Mitsutoshi

“…To understand the ultra-early reaction of normal organ lipids during irradiation, we investigated the response of lipids, including polyunsaturated fatty acid…”
Get full text