Search Results - "Kahoud, Emily"
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The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Published in Molecular cell (21-01-2016)“…While cellular GTP concentration dramatically changes in response to an organism’s cellular status, whether it serves as a metabolic cue for biological…”
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Intermediate filaments enable pathogen docking to trigger type 3 effector translocation
Published in Nature microbiology (07-03-2016)“…Type 3 secretion systems (T3SSs) of bacterial pathogens translocate bacterial effector proteins that mediate disease into the eukaryotic cytosol. Effectors…”
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Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors
Published in Science signaling (08-03-2011)“…The guanosine triphosphate (GTP)--loaded form of the guanosine triphosphatase (GTPase) Ras initiates multiple signaling pathways by binding to various…”
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Identification of lysine methylation in the core GTPase domain by GoMADScan
Published in PloS one (07-08-2019)“…RAS is the founding member of a superfamily of GTPases and regulates signaling pathways involved in cellular growth control. While recent studies have shown…”
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Correction: Identification of lysine methylation in the core GTPase domain by GoMADScan
Published in PloS one (22-10-2019)“…[This corrects the article DOI: 10.1371/journal.pone.0219436.]…”
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Characterization of KRAS rearrangements in metastatic prostate cancer
Published in Cancer discovery (01-06-2011)“…Using an integrative genomics approach called amplification breakpoint ranking and assembly analysis, we nominated KRAS as a gene fusion with the…”
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Degradation of Activated K-Ras Orthologue via K-Ras-specific Lysine Residues Is Required for Cytokinesis
Published in The Journal of biological chemistry (14-02-2014)“…Mammalian cells encode three closely related Ras proteins, H-Ras, N-Ras, and K-Ras. Oncogenic K-Ras mutations frequently occur in human cancers, which lead to…”
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Systematic Analysis of Bacterial Effector-Postsynaptic Density 95/Disc Large/Zonula Occludens-1 (PDZ) Domain Interactions Demonstrates Shigella OspE Protein Promotes Protein Kinase C Activation via PDLIM Proteins
Published in The Journal of biological chemistry (24-10-2014)“…Diseases caused by many Gram-negative bacterial pathogens depend on the activities of bacterial effector proteins that are delivered into eukaryotic cells via…”
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