Search Results - "Kahne, Daniel"

Outer Membrane Biogenesis by Konovalova, Anna, Kahne, Daniel E, Silhavy, Thomas J

“…The hallmark of gram-negative bacteria and organelles such as mitochondria and chloroplasts is the presence of an outer membrane. In bacteria such as…”
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Assembly and Maintenance of Lipids at the Bacterial Outer Membrane by Lundstedt, Emily, Kahne, Daniel, Ruiz, Natividad

“…The outer membrane of Gram-negative bacteria is essential for their survival in harsh environments and provides intrinsic resistance to many antibiotics. This…”
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On the essentiality of lipopolysaccharide to Gram-negative bacteria by Zhang, Ge, Meredith, Timothy C, Kahne, Daniel

“…Highlights • We discuss the cellular role of lipopolysaccharide within Gram-negative bacteria. • We propose explanations for why lipopolysaccharide is…”
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A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery by Rohs, Patricia D A, Buss, Jackson, Sim, Sue I, Squyres, Georgia R, Srisuknimit, Veerasak, Smith, Mandy, Cho, Hongbaek, Sjodt, Megan, Kruse, Andrew C, Garner, Ethan C, Walker, Suzanne, Kahne, Daniel E, Bernhardt, Thomas G

“…Cell elongation in rod-shaped bacteria is mediated by the Rod system, a conserved morphogenic complex that spatially controls cell wall assembly by the glycan…”
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Distinct Single-Cell Morphological Dynamics under Beta-Lactam Antibiotics by Yao, Zhizhong, Kahne, Daniel, Kishony, Roy

“…The bacterial cell wall is conserved in prokaryotes, stabilizing cells against osmotic stress. Beta-lactams inhibit cell-wall synthesis and induce lysis…”
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Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model by Okuda, Suguru, Sherman, David J., Silhavy, Thomas J., Ruiz, Natividad, Kahne, Daniel

“…Key Points The outer membrane (OM) of most Gram-negative bacteria contains lipopolysaccharide (LPS), a large molecule that contains several fatty acyl chains…”
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Regulated Assembly of the Transenvelope Protein Complex Required for Lipopolysaccharide Export by Freinkman, Elizaveta, Okuda, Suguru, Ruiz, Natividad, Kahne, Daniel

“…Gram-negative bacteria are impervious to many drugs and environmental stresses because they possess an outer membrane (OM) containing lipopolysaccharide (LPS)…”
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Reconstitution of Outer Membrane Protein Assembly from Purified Components by Hagan, Christine L, Kim, Seokhee, Kahne, Daniel

“…β-barrel membrane proteins in Gram-negative bacteria, mitochondria, and chloroplasts are assembled by highly conserved multi-protein complexes. The mechanism…”
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Structural basis of unidirectional export of lipopolysaccharide to the cell surface by Owens, Tristan W., Taylor, Rebecca J., Pahil, Karanbir S., Bertani, Blake R., Ruiz, Natividad, Kruse, Andrew C., Kahne, Daniel

“…Gram-negative bacteria are surrounded by an inner cytoplasmic membrane and by an outer membrane, which serves as a protective barrier to limit entry of many…”
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Suppressor Mutations in LptF Bypass Essentiality of LptC by Forming a Six-Protein Transenvelope Bridge That Efficiently Transports Lipopolysaccharide by Falchi, Federica A, Taylor, Rebecca J, Rowe, Sebastian J, Moura, Elisabete C C M, Baeta, Tiago, Laguri, Cedric, Simorre, Jean-Pierre, Kahne, Daniel E, Polissi, Alessandra, Sperandeo, Paola

“…Lipopolysaccharide (LPS) is an essential component of the outer membrane (OM) of many Gram-negative bacteria, providing a barrier against the entry of toxic…”
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Inhibition of the β-barrel assembly machine by a peptide that binds BamD by Hagan, Christine L., Wzorek, Joseph S., Kahne, Daniel

“…The protein complex that assembles integral membrane β-barrel proteins in the outer membranes of Gram-negative bacteria is an attractive target in the…”
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Membrane Potential Is Required for MurJ Function by Rubino, Frederick A, Kumar, Sujeet, Ruiz, Natividad, Walker, Suzanne, Kahne, Daniel E

“…MurJ, the flippase that exports the bacterial cell wall monomer Lipid II to the periplasm, is a target for new antibiotics, which are desperately needed to…”
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complex that inserts lipopolysaccharide into the bacterial outer membrane forms a two-protein plug-and-barrel by Freinkman, Elizaveta, Chng, Shu-Sin, Kahne, Daniel

“…The cell surfaces of Gram-negative bacteria are composed of lipopolysaccharide (LPS). This glycolipid is found exclusively in the outer leaflet of the…”
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Lipoprotein Cofactors Located in the Outer Membrane Activate Bacterial Cell Wall Polymerases by Paradis-Bleau, Catherine, Markovski, Monica, Uehara, Tsuyoshi, Lupoli, Tania J., Walker, Suzanne, Kahne, Daniel E., Bernhardt, Thomas G.

“…Most bacteria surround themselves with a peptidoglycan (PG) exoskeleton synthesized by polysaccharide polymerases called penicillin-binding proteins (PBPs)…”
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Transport of lipopolysaccharide across the cell envelope: the long road of discovery by Silhavy, Thomas J, Ruiz, Natividad, Kahne, Daniel

“…In this Timeline, Silhavy and colleagues trace the experiments that revealed the structure and composition of the membranes and cell wall of Gram-negative…”
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Lipopolysaccharide is transported to the cell surface by a membrane-to-membrane protein bridge by Sherman, David J, Xie, Ran, Taylor, Rebecca J, George, Alexander H, Okuda, Suguru, Foster, Peter J, Needleman, Daniel J, Kahne, Daniel

“…Gram-negative bacteria have an outer membrane that serves as a barrier to noxious agents in the environment. This protective function is dependent on…”
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MurJ is the flippase of lipid-linked precursors for peptidoglycan biogenesis by Sham, Lok-To, Butler, Emily K., Lebar, Matthew D., Kahne, Daniel, Bernhardt, Thomas G., Ruiz, Natividad

“…Peptidoglycan (PG) is a polysaccharide matrix that protects bacteria from osmotic lysis. Inhibition of its biogenesis is a proven strategy for killing bacteria…”
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Regulation of cell size in response to nutrient availability by fatty acid biosynthesis in Escherichia coli by Yao, Zhizhong, Davis, Rebecca M., Kishony, Roy, Kahne, Daniel, Ruiz, Natividad

“…Cell size varies greatly among different types of cells, but the range in size that a specific cell type can reach is limited. A long-standing question in…”
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Defining the roles of the periplasmic chaperones SurA, Skp, and DegP in Escherichia coli by Sklar, Joseph G, Wu, Tao, Kahne, Daniel, Silhavy, Thomas J

“…Integral beta-barrel proteins (OMPs) are a major class of outer membrane proteins in Gram-negative bacteria. In Escherichia coli, these proteins are…”
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Direction of Chain Growth and Substrate Preferences of Shape, Elongation, Division, and Sporulation-Family Peptidoglycan Glycosyltransferases by Welsh, Michael A, Schaefer, Kaitlin, Taguchi, Atsushi, Kahne, Daniel, Walker, Suzanne

“…The bacterial cell wall is composed of peptidoglycan, and its biosynthesis is an established target for antibiotics. Peptidoglycan is assembled from a…”
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