Structural Brain Abnormalities in Patients With Schizophrenia and Their Healthy Siblings

Structural Brain Abnormalities in Patients With Schizophrenia and Their Healthy Siblings

OBJECTIVE: The authors sought to investigate the contribution of genotype on structural brain abnormalities in schizophrenia. METHOD: Intracranial volumes and volumes of the cerebrum, white and gray matter, lateral and third ventricles, frontal lobes, caudate nucleus, amygdala, hippocampus, parahipp...

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Bibliographic Details
Published in:The American journal of psychiatry Vol. 157; no. 3; pp. 416 - 421
Main Authors: Staal, Wouter G., Hulshoff Pol, Hilleke E., Schnack, Hugo G., Hoogendoorn, Mechteld L.C., Jellema, Korn纯, Kahn, Ren矓.
Format: Journal Article
Language:English
Published: Washington, DC American Psychiatric Publishing 01-03-2000
American Psychiatric Association
Subjects:
Abnormal
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Brain
Brain - anatomy & histology
Caudate Nucleus - anatomy & histology
Cerebellum - anatomy & histology
Cerebral Ventricles - anatomy & histology
Cerebrospinal Fluid - physiology
Family
Female
Frontal Lobe - anatomy & histology
Genetic Predisposition to Disease
Genotype
Humans
Magnetic Resonance Imaging
Male
Medical disorders
Medical sciences
Patients
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - epidemiology
Schizophrenia - genetics
Siblings
Structure
Human
Volumetric analysis
Healthy subject
Family study
Central nervous system
Schizophrenia
Sibling
Genetic determinism
Nuclear magnetic resonance imaging
Psychosis
Medical imagery
Genetics
Comparative study
Brain (vertebrata)
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Summary:OBJECTIVE: The authors sought to investigate the contribution of genotype on structural brain abnormalities in schizophrenia. METHOD: Intracranial volumes and volumes of the cerebrum, white and gray matter, lateral and third ventricles, frontal lobes, caudate nucleus, amygdala, hippocampus, parahippocampal gyrus, and the cerebellum were measured in 32 same-sex siblings discordant for schizophrenia and 32 matched comparison subjects by means of magnetic resonance imaging. RESULTS: Third ventricle volumes did not differ between the schizophrenic patients and their healthy siblings. However, both had higher third ventricle volumes than did the comparison subjects. The schizophrenic patients had lower cerebrum volumes than did the comparison subjects, whereas the cerebrum volume of the healthy siblings did not significantly differ from the patients or comparison subjects. Additionally, patients with schizophrenia displayed a volume reduction of the frontal lobe gray matter and a volume increase of the caudate nuclei and lateral ventricles compared to both their healthy siblings and comparison subjects. Intracranial volume, CSF volume, or volumes of the cerebellum, amygdala, hippocampus, or the parahippocampal gyrus did not significantly differ among the patients, siblings, and comparison subjects. CONCLUSIONS: Healthy siblings share third ventricle enlargement with their affected relatives and may partially display a reduction in cerebral volume. These findings suggest that third ventricular enlargement, and to some extent cerebral volume decrease, may be related to genetic defects that produce a susceptibility to schizophrenia.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.157.3.416