Search Results - "Kahn, Mark L"

Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation by Nonomura, Keiko, Lukacs, Viktor, Sweet, Daniel T., Goddard, Lauren M., Kanie, Akemi, Whitwam, Tess, Ranade, Sanjeev S., Fujimori, Toshihiko, Kahn, Mark L., Patapoutian, Ardem

“…PIEZO1 is a cation channel that is activated by mechanical forces such as fluid shear stress or membrane stretch. PIEZO1 loss-of-function mutations in patients…”
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Cerebral Cavernous Malformation: From Mechanism to Therapy by Snellings, Daniel A., Hong, Courtney C., Ren, Aileen A., Lopez-Ramirez, Miguel A., Girard, Romuald, Srinath, Abhinav, Marchuk, Douglas A., Ginsberg, Mark H., Awad, Issam A., Kahn, Mark L.

“…Cerebral cavernous malformations are acquired vascular anomalies that constitute a common cause of central nervous system hemorrhage and stroke. The past 2…”
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Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage by Reed, Hasina Outtz, Wang, Liqing, Sonett, Jarrod, Chen, Mei, Yang, Jisheng, Li, Larry, Aradi, Petra, Jakus, Zoltan, D'Armiento, Jeanine, Hancock, Wayne W, Kahn, Mark L

“…The lung is a specialized barrier organ that must tightly regulate interstitial fluid clearance and prevent infection in order to maintain effective gas…”
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The Cerebral Cavernous Malformation Pathway Controls Cardiac Development via Regulation of Endocardial MEKK3 Signaling and KLF Expression by Zhou, Zinan, Rawnsley, David R., Goddard, Lauren M., Pan, Wei, Cao, Xing-Jun, Jakus, Zoltan, Zheng, Hui, Yang, Jisheng, Arthur, J. Simon C., Whitehead, Kevin J., Li, Dean, Zhou, Bin, Garcia, Benjamin A., Zheng, Xiangjian, Kahn, Mark L.

“…The cerebral cavernous malformation (CCM) pathway is required in endothelial cells for normal cardiovascular development and to prevent postnatal vascular…”
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PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism by Ren, Aileen A., Snellings, Daniel A., Su, Yourong S., Hong, Courtney C., Castro, Marco, Tang, Alan T., Detter, Matthew R., Hobson, Nicholas, Girard, Romuald, Romanos, Sharbel, Lightle, Rhonda, Moore, Thomas, Shenkar, Robert, Benavides, Christian, Beaman, M. Makenzie, Müller-Fielitz, Helge, Chen, Mei, Mericko, Patricia, Yang, Jisheng, Sung, Derek C., Lawton, Michael T., Ruppert, J. Michael, Schwaninger, Markus, Körbelin, Jakob, Potente, Michael, Awad, Issam A., Marchuk, Douglas A., Kahn, Mark L.

“…Vascular malformations are thought to be monogenic disorders that result in dysregulated growth of blood vessels. In the brain, cerebral cavernous…”
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Endothelial TLR4 and the microbiome drive cerebral cavernous malformations by Tang, Alan T., Choi, Jaesung P., Kotzin, Jonathan J., Yang, Yiqing, Hong, Courtney C., Hobson, Nicholas, Girard, Romuald, Zeineddine, Hussein A., Lightle, Rhonda, Moore, Thomas, Cao, Ying, Shenkar, Robert, Chen, Mei, Mericko, Patricia, Yang, Jisheng, Li, Li, Tanes, Ceylan, Kobuley, Dmytro, Võsa, Urmo, Whitehead, Kevin J., Li, Dean Y., Franke, Lude, Hart, Blaine, Schwaninger, Markus, Henao-Mejia, Jorge, Morrison, Leslie, Kim, Helen, Awad, Issam A., Zheng, Xiangjian, Kahn, Mark L.

“…Cerebral cavernous malformations (CCMs) are a cause of stroke and seizure for which no effective medical therapies yet exist. CCMs arise from the loss of an…”
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Lymphovenous hemostasis and the role of platelets in regulating lymphatic flow and lymphatic vessel maturation by Welsh, John D., Kahn, Mark L., Sweet, Daniel T.

“…Aside from the established role for platelets in regulating hemostasis and thrombosis, recent research has revealed a discrete role for platelets in the…”
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Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow by Betterman, Kelly L, Sutton, Drew L, Secker, Genevieve A, Kazenwadel, Jan, Oszmiana, Anna, Lim, Lillian, Miura, Naoyuki, Sorokin, Lydia, Hogan, Benjamin M, Kahn, Mark L, McNeill, Helen, Harvey, Natasha L

“…The atypical cadherin FAT4 has established roles in the regulation of planar cell polarity and Hippo pathway signaling that are cell context dependent. The…”
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Platelets and Tumor Cells: A New Form of Border Control by Stanger, Ben Z., Kahn, Mark L.

“…Tumor metastasis is the primary cause of death due to cancer, but the mechanisms by which tumor cells metastasize remain incompletely understood. In this issue…”
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Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD by Bui, Hung M, Enis, David, Robciuc, Marius R, Nurmi, Harri J, Cohen, Jennifer, Chen, Mei, Yang, Yiqing, Dhillon, Veerpal, Johnson, Kathy, Zhang, Hong, Kirkpatrick, Robert, Traxler, Elizabeth, Anisimov, Andrey, Alitalo, Kari, Kahn, Mark L

“…Lymphangiogenesis is supported by 2 homologous VEGFR3 ligands, VEGFC and VEGFD. VEGFC is required for lymphatic development, while VEGFD is not. VEGFC and…”
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Platelet ITAM signaling is critical for vascular integrity in inflammation by Boulaftali, Yacine, Hess, Paul R, Getz, Todd M, Cholka, Agnieszka, Stolla, Moritz, Mackman, Nigel, Owens, 3rd, A Phillip, Ware, Jerry, Kahn, Mark L, Bergmeier, Wolfgang

“…Platelets play a critical role in maintaining vascular integrity during inflammation, but little is known about the underlying molecular mechanisms. Here we…”
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Hemostasis stimulates lymphangiogenesis through release and activation of VEGFC by Lim, Lillian, Bui, Hung, Farrelly, Olivia, Yang, Jisheng, Li, Li, Enis, David, Ma, Wanshu, Chen, Mei, Oliver, Guillermo, Welsh, John D., Kahn, Mark L.

“…Hemostasis associated with tissue injury is followed by wound healing, a complex process by which damaged cellular material is removed and tissue repaired…”
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Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis by Goddard, Lauren M., Duchemin, Anne-Laure, Ramalingan, Harini, Wu, Bingruo, Chen, Mei, Bamezai, Sharika, Yang, Jisheng, Li, Li, Morley, Michael P., Wang, Tao, Scherrer-Crosbie, Marielle, Frank, David B., Engleka, Kurt A., Jameson, Stephen C., Morrisey, Edward E., Carroll, Thomas J., Zhou, Bin, Vermot, Julien, Kahn, Mark L.

“…Hemodynamic forces play an essential epigenetic role in heart valve development, but how they do so is not known. Here, we show that the shear-responsive…”
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Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodeling by Pawlak, John B, Bálint, László, Lim, Lillian, Ma, Wanshu, Davis, Reema B, Benyó, Zoltán, Soares, Michael J, Oliver, Guillermo, Kahn, Mark L, Jakus, Zoltán, Caron, Kathleen M

“…Molecular heterogeneity of endothelial cells underlies their highly specialized functions during changing physiological conditions within diverse vascular…”
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Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection by Tang, Alan T, Buchholz, David W, Szigety, Katherine M, Imbiakha, Brian, Gao, Siqi, Frankfurter, Maxwell, Wang, Min, Yang, Jisheng, Hewins, Peter, Mericko-Ishizuka, Patricia, Leu, N Adrian, Sterling, Stephanie, Monreal, Isaac A, Sahler, Julie, August, Avery, Zhu, Xuming, Jurado, Kellie A, Xu, Mingang, Morrisey, Edward E, Millar, Sarah E, Aguilar, Hector C, Kahn, Mark L

“…Angiotensin-converting enzyme 2 (ACE2) is the cell-surface receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). While its central role in…”
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CCBE1 regulates the development and prevents the age-dependent regression of meningeal lymphatics by Ocskay, Zsombor, Bálint, László, Christ, Carolin, Kahn, Mark L., Jakus, Zoltán

“…Recent studies have described the importance of lymphatics in numerous organ-specific physiological and pathological processes. The role of meningeal…”
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Platelets regulate lymphatic vascular development through CLEC-2–SLP-76 signaling by Bertozzi, Cara C., Schmaier, Alec A., Mericko, Patricia, Hess, Paul R., Zou, Zhiying, Chen, Mei, Chen, Chiu-Yu, Xu, Bin, Lu, Min-min, Zhou, Diane, Sebzda, Eric, Santore, Matthew T., Merianos, Demetri J., Stadtfeld, Matthias, Flake, Alan W., Graf, Thomas, Skoda, Radek, Maltzman, Jonathan S., Koretzky, Gary A., Kahn, Mark L.

“…Although platelets appear by embryonic day 10.5 in the developing mouse, an embryonic role for these cells has not been identified. The SYK–SLP-76 signaling…”
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VEGFR3 is required for button junction formation in lymphatic vessels by Jannaway, Melanie, Iyer, Drishya, Mastrogiacomo, Diandra M., Li, Kunyu, Sung, Derek C., Yang, Ying, Kahn, Mark L., Scallan, Joshua P.

“…Lymphatic capillaries develop discontinuous cell-cell junctions that permit the absorption of large macromolecules, chylomicrons, and fluid from the…”
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Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2 by Acton, Sophie E., Astarita, Jillian L., Malhotra, Deepali, Lukacs-Kornek, Veronika, Franz, Bettina, Hess, Paul R., Jakus, Zoltan, Kuligowski, Michael, Fletcher, Anne L., Elpek, Kutlu G., Bellemare-Pelletier, Angelique, Sceats, Lindsay, Reynoso, Erika D., Gonzalez, Santiago F., Graham, Daniel B., Chang, Jonathan, Peters, Anneli, Woodruff, Matthew, Kim, Young-A., Swat, Wojciech, Morita, Takashi, Kuchroo, Vijay, Carroll, Michael C., Kahn, Mark L., Wucherpfennig, Kai W., Turley, Shannon J.

“…To initiate adaptive immunity, dendritic cells (DCs) move from parenchymal tissues to lymphoid organs by migrating along stromal scaffolds that display the…”
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Vascular Development for Climate Control by Kahn, Mark L.

“…Early anatomists noted the close juxtaposition of arteries and veins, which modern physiologists proposed aided temperature regulation. In this issue of…”
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