Search Results - "Kahli, Malik"

Transcription shapes DNA replication initiation and termination in human cells by Chen, Yu-Hung, Keegan, Sarah, Kahli, Malik, Tonzi, Peter, Fenyö, David, Huang, Tony T., Smith, Duncan J.

“…Although DNA replication is a fundamental aspect of biology, it is not known what determines where DNA replication starts and stops in the human genome. We…”
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Replication landscape of the human genome by Petryk, Nataliya, Kahli, Malik, d'Aubenton-Carafa, Yves, Jaszczyszyn, Yan, Shen, Yimin, Silvain, Maud, Thermes, Claude, Chen, Chun-Long, Hyrien, Olivier

“…Despite intense investigation, human replication origins and termini remain elusive. Existing data have shown strong discrepancies. Here we sequenced highly…”
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Zac1 Regulates an Imprinted Gene Network Critically Involved in the Control of Embryonic Growth by Varrault, Annie, Gueydan, Charlotte, Delalbre, Annie, Bellmann, Anja, Houssami, Souheir, Aknin, Cindy, Severac, Dany, Chotard, Laetitia, Kahli, Malik, Le Digarcher, Anne, Pavlidis, Paul, Journot, Laurent

“…Genomic imprinting is an epigenetic mechanism of regulation that restrains the expression of a small subset of mammalian genes to one parental allele. The…”
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Monitoring genome-wide replication fork directionality by Okazaki fragment sequencing in mammalian cells by Kit Leng Lui, Sarah, Keegan, Sarah, Tonzi, Peter, Kahli, Malik, Chen, Yu-Hung, Chalhoub, Noor, Coleman, Kate E., Fenyo, David, Smith, Duncan J., Huang, Tony T.

“…The ability to monitor DNA replication fork directionality at the genome-wide scale is paramount for a greater understanding of how genetic and environmental…”
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From Simple Bacterial and Archaeal Replicons to Replication N/U-Domains by Hyrien, Olivier, Rappailles, Aurélien, Guilbaud, Guillaume, Baker, Antoine, Chen, Chun-Long, Goldar, Arach, Petryk, Nataliya, Kahli, Malik, Ma, Emilie, d'Aubenton-Carafa, Yves, Audit, Benjamin, Thermes, Claude, Arneodo, Alain

“…The Replicon Theory proposed 50years ago has proven to apply for replicons of the three domains of life. Here, we review our knowledge of genome organization…”
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From the chromatin interaction network to the organization of the human genome into replication N/U-domains by Boulos, Rasha E, Julienne, Hanna, Baker, Antoine, Chen, Chun-Long, Petryk, Nataliya, Kahli, Malik, dʼAubenton-Carafa, Yves, Goldar, Arach, Jensen, Pablo, Hyrien, Olivier, Thermes, Claude, Arneodo, Alain, Audit, Benjamin

“…The three-dimensional (3D) architecture of the mammalian nucleus is now being unraveled thanks to the recent development of chromatin conformation capture (3C)…”
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Processing of eukaryotic Okazaki fragments by redundant nucleases can be uncoupled from ongoing DNA replication in vivo by Kahli, Malik, Osmundson, Joseph S, Yeung, Rani, Smith, Duncan J

“…Abstract Prior to ligation, each Okazaki fragment synthesized on the lagging strand in eukaryotes must be nucleolytically processed. Nuclease cleavage takes…”
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Les micro-ARNs salivaires en tant que biomarqueurs pour le diagnostic des commotions cérébrales by Kahli, Malik, Van-Der-Hofstadt, Marc, Boulestreau, Jérémy, Van, Thi Nhu Ngoc, Molina, Franck

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Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions by Wu, Xia, Kabalane, Hadi, Kahli, Malik, Petryk, Nataliya, Laperrousaz, Bastien, Jaszczyszyn, Yan, Drillon, Guenola, Nicolini, Frank-Emmanuel, Perot, Gaëlle, Robert, Aude, Fund, Cédric, Chibon, Frédéric, Xia, Ruohong, Wiels, Joëlle, Argoul, Françoise, Maguer-Satta, Véronique, Arneodo, Alain, Audit, Benjamin, Hyrien, Olivier

“…Abstract The spatiotemporal program of metazoan DNA replication is regulated during development and altered in cancers. We have generated novel OK-seq,…”
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Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions by Wu, Xia, Kabalane, Hadi, Kahli, Malik, Petryk, Nataliya, Laperrousaz, Bastien, Jaszczyszyn, Yan, Drillon, Guenola, Nicolini, Frank-Emmanuel, Perot, Gaëlle, Robert, Aude, Fund, Cédric, Chibon, Frédéric, Xia, Ruohong, Wiels, Joëlle, Argoul, Françoise, Maguer-Satta, Véronique, Arneodo, Alain, Audit, Benjamin, Hyrien, Olivier

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Les micro-ARNs salivaires en tant que biomarqueurs pour le diagnostic des commotions cérébrales by Kahli, Malik, Van-Der-Hofstadt, Marc, Boulestreau, Jérémy, Van, Thi Nhu Ngoc, Molina, Franck

“…La commotion cérébrale est un enjeu de santé majeur en particulier chez les sportifs. Cependant, les moyens actuels ne permettent pas de détecter de manière…”
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Deciphering DNA replication dynamics in eukaryotic cell populations in relation with their averaged chromatin conformations OPEN by Goldar, Arach, Arneodo, A., Audit, B., Argoul, Françoise, Rappailles, A., Guilbaud, G., Petryk, Nataliya, Kahli, Malik, Hyrien, Olivier

“…We propose a non-local model of DNA replication that takes into account the observed uncertainty on the position and time of replication initiation in…”
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SUMO2/3 modification of cyclin E contributes to the control of replication origin firing by Bonne-Andrea, Catherine, Kahli, Malik, Mechali, Francisca, Lemaitre, Jean-Marc, Bossis, Guillaume, Coux, Olivier

“…The small ubiquitin-like modifier (SUMO) pathway is essential for the maintenance of genome stability. We investigated its possible involvement in the control…”
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Mapping replication origin sequences in eukaryotic chromosomes by Fu, Haiqing, Besnard, Emilie, Desprat, Romain, Ryan, Michael, Kahli, Malik, Lemaitre, Jean-Marc, Aladjem, Mirit I

“…Recent advances in genome-sequencing technology have led to the complete mapping of DNA replication initiation sites in the human genome. This thorough origin…”
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Best practices for mapping replication origins in eukaryotic chromosomes by Besnard, Emilie, Desprat, Romain, Ryan, Michael, Kahli, Malik, Aladjem, Mirit I, Lemaitre, Jean-Marc

“…Understanding the regulatory principles ensuring complete DNA replication in each cell division is critical for deciphering the mechanisms that maintain…”
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