Search Results - "Kahle, Michael P."

Perlecan Domain-V Enhances Neurogenic Brain Repair After Stroke in Mice by Trout, Amanda L., Kahle, Michael P., Roberts, Jill M., Marcelo, Aileen, de Hoog, Leon, Boychuk, Jeffery A., Grupke, Stephen L., Berretta, Antonio, Gowing, Emma K., Boychuk, Carie R., Gorman, Amanda A., Edwards, Danielle N., Rutkai, Ibolya, Biose, Ifechukwude J., Ishibashi-Ueda, Hatsue, Ihara, Masafumi, Smith, Bret N., Clarkson, Andrew N., Bix, Gregory J.

“…The extracellular matrix fragment perlecan domain V is neuroprotective and functionally restorative following experimental stroke. As neurogenesis is an…”
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MEKK2 regulates paxillin ubiquitylation and localization in MDA-MB 231 breast cancer cells by Ameka, Magdalene, Kahle, Michael P, Perez-Neut, Mathew, Gentile, Saverio, Mirza, Ahmed A, Cuevas, Bruce D

“…The intracellular kinase MEKK2 (mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase kinase 2) is an upstream regulator of JNK (c-Jun…”
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Perlecan and the blood-brain barrier: beneficial proteolysis? by Roberts, Jill, Kahle, Michael P, Bix, Gregory J

“…The cerebral microvasculature is important for maintaining brain homeostasis. This is achieved via the blood-brain barrier (BBB), composed of endothelial cells…”
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Successfully Climbing the ＂STAIRs＂: Surmounting Failed Translation of Experimental Ischemic Stroke Treatments by Kahle, Michael P., Bix, Gregory J.

“…The Stroke Therapy Academic Industry Roundtable (STAIR) provided initial (in 1999) and updated (in 2009) recommendations with the goal of improving preclinical…”
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Convergent MAPK pathway alterations mediate acquired resistance to FGFR inhibitors in FGFR2 fusion-positive cholangiocarcinoma by DiPeri, Timothy P., Zhao, Ming, Evans, Kurt W., Varadarajan, Kaushik, Moss, Tyler, Scott, Stephen, Kahle, Michael P., Byrnes, Charnel C., Chen, Huiqin, Lee, Sunyoung S., Halim, Abdel-Baset, Hirai, Hiroshi, Wacheck, Volker, Kwong, Lawrence N., Rodon, Jordi, Javle, Milind, Meric-Bernstam, Funda

“…There is a knowledge gap in understanding mechanisms of resistance to fibroblast growth factor receptor (FGFR) inhibitors (FGFRi) and a need for novel…”
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CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC by Becker, Jeffrey H, Gao, Yandi, Soucheray, Margaret, Pulido, Ines, Kikuchi, Eiki, Rodríguez, María L, Gandhi, Rutu, Lafuente-Sanchis, Aranzazu, Aupí, Miguel, Alcácer Fernández-Coronado, Javier, Martín-Martorell, Paloma, Cremades, Antonio, Galbis-Caravajal, José M, Alcácer, Javier, Christensen, Camilla L, Simms, Patricia, Hess, Ashley, Asahina, Hajime, Kahle, Michael P, Al-Shahrour, Fatima, Borgia, Jeffrey A, Lahoz, Agustín, Insa, Amelia, Juan, Oscar, Jänne, Pasi A, Wong, Kwok-Kin, Carretero, Julian, Shimamura, Takeshi

“…Although EGFR mutant-selective tyrosine kinase inhibitors (TKI) are clinically effective, acquired resistance can occur by reactivating ERK. We show using…”
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Neuronal Restoration Following Ischemic Stroke: Influences, Barriers, and Therapeutic Potential by Kahle, Michael P., Bix, Gregory J.

“…Neurogenesis, the birth of new neurons, occurs throughout life in the subventricular zone and produces immature neurons that migrate tangentially through the…”
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MEKK2 regulates focal adhesion stability and motility in invasive breast cancer cells by Mirza, Ahmed A., Kahle, Michael P., Ameka, Magdalene, Campbell, Edward M., Cuevas, Bruce D.

“…MEK Kinase 2 (MEKK2) is a serine/threonine kinase that functions as a MAPK kinase kinase (MAP3K) to regulate activation of Mitogen-activated Protein Kinases…”
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Interaction with the Paxillin LD1 Motif Relieves MEKK2 Auto-inhibition by Kahle, Michael P, Cuevas, Bruce D

“…The cell signaling molecule MEK kinase 2 (MEKK2) is a key upstream regulator of MAPK activity that regulates numerous cellular functions, but the mechanisms…”
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Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue by KAHLE, Michael P, LEE, Boyeon, YOUNG, William L, BIX, Gregory J, POURMOHAMAD, Tony, CUNNINGHAM, Austin, HUA SU, KIM, Helen, YONGMEI CHEN, MCCULLOCH, Charles E, BARBARO, Nicholas M, LAWTON, Michael T

“…Brain arteriovenous malformation (BAVM), a rare but important cause of intracranial hemorrhage, has increased angiogenesis and inflammation as key components…”
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Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue by Kahle, Michael P, Lee, Boyeon, Pourmohamad, Tony, Cunningham, Austin, Su, Hua, Kim, Helen, Chen, Yongmei, McCulloch, Charles E, Barbaro, Nicholas M, Lawton, Michael T, Young, William L, Bix, Gregory J

“…Brain arteriovenous malformation (BAVM), a rare but important cause of intracranial hemorrhage, has increased angiogenesis and inflammation as key components…”
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Abstract 2710: The MD Anderson patient-derived xenograft series for modeling precision oncology in biliary tract cancers by DiPeri, Timothy Philip, Evans, Kurt W., Tzeng, Ching-Wei D., Kwong, Lawrence, Kahle, Michael P., Zheng, Xiaofeng, Li, Dali, Cao, Hop S. Tran, Vu, Thuy, Kim, Sunhee, Su, Fei, Kirby, Bryce, Wathoo, Chetna, Raso, Gabriela, Rizvi, Yasmin, Wang, Huamin, Janku, Filip, Shaw, Kenna, Yap, Timothy, Javle, Milind, Rodon, Jordi, Meric-Bernstam, Funda

“…Abstract Purpose: Biliary tract cancers (BTCs), including intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma (ECC), and gallbladder cancer…”
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Abstract LB-085: A new role for LKB1 to regulate Heat Shock Protein 90 activity by Becker, Jeffrey H., Kahle, Michael P., Soucheray, Margaret, Pulido, Ines, Al-Shahrour, Fatima, Pino, Manuel Sanchez del, Wong, Kwok-Kin, Carretero, Julian, Shimamura, Takeshi

“…Abstract Approximately 30% of human non-small cell lung cancer (NSCLC) patients harbor a somatic KRAS mutation resulting, in aberrant activation of downstream…”
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Perlecan Domain V is Upregulated in Human Brain Arteriovenous Malformation (BAVM) and could Mediate VEGF Effect in Lesional Tissue by Kahle, Michael P., Lee, Boyeon, Pourmohamad, Tony, Cunningham, Austin, Su, Hua, Kim, Helen, Chen, Yongmei, McCulloch, Charles E., Barbaro, Nicholas M., Lawton, Michael T., Young, William L., Bix, Gregory J.

“…Brain arteriovenous malformation (BAVM), a rare but important cause of intracranial hemorrhage, has increased angiogenesis and inflammation as key components…”
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