Search Results - "Kahle, K T"

Local Impermeant Anions Establish the Neuronal Chloride Concentration by Glykys, J., Dzhala, V., Egawa, K., Balena, T, Saponjian, Y., Kuchibhotla, K. V., Bacskai, B. J., Kahle, K. T., Zeuthen, T., Staley, K. J.

“…Neuronal intracellular chloride concentration [Cl–]i is an important determinant of γ-aminobutyric acid type A (GABAA) receptor (GABAAR)–mediated inhibition…”
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In Xenopus ependymal cilia drive embryonic CSF circulation and brain development independently of cardiac pulsatile forces by Dur, A H, Tang, T, Viviano, S, Sekuri, A, Willsey, H R, Tagare, H D, Kahle, K T, Deniz, E

“…Hydrocephalus, the pathological expansion of the cerebrospinal fluid (CSF)-filled cerebral ventricles, is a common, deadly disease. In the adult, cardiac and…”
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Response to comments on "Local impermeant anions establish the neuronal chloride concentration" by Glykys, J, Dzhala, V, Egawa, K, Balena, T, Saponjian, Y, Kuchibhotla, K V, Bacskai, B J, Kahle, K T, Zeuthen, T, Staley, K J

“…We appreciate the interest in our paper and the opportunity to clarify theoretical and technical aspects describing the influence of Donnan equilibria on…”
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EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer by Eichler, April F., Kahle, Kristopher T., Wang, Daphne L., Joshi, Victoria A., Willers, Henning, Engelman, Jeffrey A., Lynch, Thomas J., Sequist, Lecia V.

“…A small subset of patients with nonsmall cell lung cancer (NSCLC) harbors mutations in the epidermal growth factor receptor (EGFR) that predict unique…”
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Molecular Pathogenesis of Inherited Hypertension with Hyperkalemia: The Na-Cl Cotransporter Is Inhibited by Wild-Type but Not Mutant WNK4 by Wilson, Frederick H., Kahle, Kristopher T., Sabath, Ernesto, Lalioti, Maria D., Rapson, Alicia K., Hoover, Robert S., Hebert, Steven C., Gamba, Gerardo, Lifton, Richard P.

“…Mutations in the serine-threonine kinases WNK1 and WNK4 [with no lysine (K) at a key catalytic residue] cause pseudohypoaldosteronism type II (PHAII), a…”
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ERK7 Is an Autoactivated Member of the MAPK Family by Abe, Mark K., Kahle, Kristopher T., Saelzler, Matthew P., Orth, Kim, Dixon, Jack E., Rosner, Marsha R.

“…Extracellular signal-regulated kinase 7 (ERK7) shares significant sequence homology with other members of the ERK family of signal transduction proteins,…”
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EGFR mutation status and survival after diagnosis of brain metastasis in non-small cell lung cancer by Eichler, A. F., Kahle, K. T., Wang, D. L., Joshi, V. A., Engelman, J. A., Sequist, L. V.

“…Abstract only…”
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Role of NKCC1 and KCC2 in the development of chronic neuropathic pain following spinal cord injury by Hasbargen, Tera, Ahmed, Mostafa M., Miranpuri, Gurwattan, Li, Lin, Kahle, Kristopher T., Resnick, Daniel, Sun, Dandan

“…Neuropathic pain is a common problem following spinal cord injury (SCI). Effective analgesic therapy has been hampered by the lack of knowledge about the…”
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ERK8, a New Member of the Mitogen-activated Protein Kinase Family by Abe, Mark K., Saelzler, Matthew P., Espinosa, Rafael, Kahle, Kristopher T., Hershenson, Marc B., Le Beau, Michelle M., Rosner, Marsha Rich

“…The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. By using the rat ERK7 cDNA to screen a human multiple…”
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WNK4 regulates the balance between renal NaCl reabsorption and K + secretion by O'Connell, Anthony D, MacGregor, Gordon G, Wilson, Frederick H, Dong, Ke, Kahle, Kristopher T, Lalioti, Maria D, Lifton, Richard P, Leng, Qiang, Hebert, Steven C, Giebisch, Gerhard, Rapson, Alicia K

“…A key question in systems biology is how diverse physiologic processes are integrated to produce global homeostasis. Genetic analysis can contribute by…”
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WNK3 Kinase Is a Positive Regulator of NKCC2 and NCC, Renal$Cation-Cl^-$Cotransporters Required for Normal Blood Pressure Homeostasis by Rinehart, Jesse, Kahle, Kristopher T., Paola de los Heros, Vazquez, Norma, Patricia Meade, Wilson, Frederick H., Hebert, Steven C., Gimenez, Ignacio, Gamba, Gerardo, Lifton, Richard P.

“…WNK1 and WNK4 [WNK, with no lysine (K)] are serine-threonine kinases that function as molecular switches, eliciting coordinated effects on diverse ion…”
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Paracellular Cl- Permeability Is Regulated by WNK4 Kinase: Insight into Normal Physiology and Hypertension by Kahle, Kristopher T., MacGregor, Gordon G., Wilson, Frederick H., Van Hoek, Alfred N., Brown, Dennis, Ardito, Thomas, Kashgarian, Michael, Giebisch, Gerhard, Hebert, Steven C., Boulpaep, Emile L., Lifton, Richard P.

“…Paracellular ion flux across epithelia occurs through selective and regulated pores in tight junctions; this process is poorly understood. Mutations in the…”
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WNK4 Regulates Apical and Basolateral Cl-Flux in Extrarenal Epithelia by Kahle, Kristopher T., Gimenez, Ignacio, Hassan, Hatim, Wilson, Frederick H., Wong, Robert D., Forbush, Biff, Aronson, Peter S., Lifton, Richard P.

“…Mutations in the serine-threonine kinase WNK4 [with no lysine (K) 4] cause pseudohypoaldosteronism type II, a Mendelian disease featuring hypertension with…”
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Hypertension, Age, and Location Predict Rupture of Small Intracranial Aneurysms by Nahed, Brian V., DiLuna, Michael L., Morgan, Thomas, Ocal, Eylem, Hawkins, Abigail A., Ozduman, Koray, Kahle, Kristopher T., Chamberlain, Andrea, Amar, Arun P., Gunel, Murat

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Central nervous system lymphoma presenting as trigeminal neuralgia: A diagnostic challenge by Ang, Jensen W.J, Khanna, Arjun, Walcott, Brian P, Kahle, Kristopher T, Eskandar, Emad N

“…Abstract We describe an atypical man with diffuse large B cell lymphoma localized to the sphenoid wing and adjacent cavernous sinus, initially presenting with…”
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WNK3 Bypasses the Tonicity Requirement for K-Cl Cotransporter Activation via a Phosphatase-Dependent Pathway by de los Heros, Paola, Kahle, Kristopher T., Rinehart, Jesse, Bobadilla, Norma A., Vázquez, Norma, San Cristobal, Pedro, Mount, David B., Lifton, Richard P., Hebert, Steven C., Gamba, Gerardo

“…SLC12A cation/Cl⁻ cotransporters are mutated in human disease, are targets of diuretics, and are collectively involved in the regulation of cell volume,…”
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WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl super([minus])-transporting epithelia by Choate, KA, Kahle, K T, Wilson, F H, Nelson-Williams, C, Lifton, R P

“…Mutations in WNK1 and WNK4, genes encoding members of a novel family of serine-threonine kinases, have recently been shown to cause pseudohypoaldosteronism…”
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WNK1, a Kinase Mutated in Inherited Hypertension with Hyperkalemia, Localizes to Diverse Cl--Transporting Epithelia by Choate, Keith A., Kahle, Kristopher T., Wilson, Frederick H., Nelson-Williams, Carol, Lifton, Richard P.

“…Mutations in WNK1 and WNK4, genes encoding members of a novel family of serine-threonine kinases, have recently been shown to cause pseudohypoaldosteronism…”
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WNK4 regulates apical and basolateral Cl super(-) flux in extrarenal epithelia by Kahle, K T, Gimenez, I, Hassan, H, Wilson, F H, Wong, R D, bush, B, Aronson, P S, Lifton, R P

“…Mutations in the serine-threonine kinase WNK4 [with no lysine (K) 4] cause pseudohypoaldosteronism type II, a Mendelian disease featuring hypertension with…”
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Regulation of diverse ion transport pathways by WNK4 kinase: a novel molecular switch by Kahle, Kristopher T., Wilson, Frederick H., Lifton, Richard P.

“…Key components of complex physiological regulatory pathways can be uncovered through the molecular-genetic study of rare, inherited diseases. WNK kinases are a…”
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