Search Results - "Kahl, Barbara C."

Clinical Significance and Pathogenesis of Staphylococcal Small Colony Variants in Persistent Infections by Kahl, Barbara C, Becker, Karsten, Löffler, Bettina

“…Small colony variants (SCVs) were first described more than 100 years ago for Staphylococcus aureus and various coagulase-negative staphylococci. Two decades…”
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Small colony variants (SCVs) of Staphylococcus aureus – A bacterial survival strategy by Kahl, Barbara C.

“…•S. aureus SCVs are selected during exponential growth and under harsh conditions.•S. aureus SCVs are associated with persistent infection.•S. aureus SCVs…”
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Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation by Tomlinson, Kira L., Lung, Tania Wong Fok, Dach, Felix, Annavajhala, Medini K., Gabryszewski, Stanislaw J., Groves, Ryan A., Drikic, Marija, Francoeur, Nancy J., Sridhar, Shwetha H., Smith, Melissa L., Khanal, Sara, Britto, Clemente J., Sebra, Robert, Lewis, Ian, Uhlemann, Anne-Catrin, Kahl, Barbara C., Prince, Alice S., Riquelme, Sebastián A.

“…Staphylococcus aureus is a prominent human pathogen that readily adapts to host immune defenses. Here, we show that, in contrast to Gram-negative pathogens, S…”
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Antibiotic activity against small-colony variants of Staphylococcus aureus: review of in vitro, animal and clinical data by Garcia, Laetitia G, Lemaire, Sandrine, Kahl, Barbara C, Becker, Karsten, Proctor, Richard A, Denis, Olivier, Tulkens, Paul M, Van Bambeke, Françoise

“…The pathogen Staphylococcus aureus uses various strategies for persisting in the host, among which switching to a small-colony variant (SCV) phenotype is of…”
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Staphylococcus aureus panton-valentine leukocidin is a very potent cytotoxic factor for human neutrophils by Löffler, Bettina, Hussain, Muzaffar, Grundmeier, Matthias, Brück, Michaela, Holzinger, Dirk, Varga, Georg, Roth, Johannes, Kahl, Barbara C, Proctor, Richard A, Peters, Georg

“…The role of the pore-forming Staphylococcus aureus toxin Panton-Valentine leukocidin (PVL) in severe necrotizing diseases is debated due to conflicting data…”
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Role of Efflux in Antibiotic Resistance of Achromobacter xylosoxidans and Achromobacter insuavis Isolates From Patients With Cystic Fibrosis by Chalhoub, Hussein, Kampmeier, Stefanie, Kahl, Barbara C, Van Bambeke, Françoise

“…genus (including , the most prevalent species in patients with cystic fibrosis) is poorly susceptible to most conventional antibiotics. Contribution of efflux…”
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Editorial: Co-Infection and Consequences in Cystic Fibrosis by Kahl, Barbara C., Moreau, Karen

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Thymidine-Dependent Staphylococcus aureus Small-Colony Variants Are Induced by Trimethoprim-Sulfamethoxazole (SXT) and Have Increased Fitness during SXT Challenge by Kriegeskorte, Andre, Lorè, Nicola Ivan, Bragonzi, Alessandra, Riva, Camilla, Kelkenberg, Marco, Becker, Karsten, Proctor, Richard A, Peters, Georg, Kahl, Barbara C

“…Trimethoprim-sulfamethoxazole (SXT) is a possible alternative for the treatment of community- and hospital-acquired methicillin-resistant Staphylococcus aureus…”
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High-level resistance to meropenem in clinical isolates of Pseudomonas aeruginosa in the absence of carbapenemases: role of active efflux and porin alterations by Chalhoub, Hussein, Sáenz, Yolanda, Rodriguez-Villalobos, Hector, Denis, Olivier, Kahl, Barbara C, Tulkens, Paul M, Van Bambeke, Françoise

“…Highlights • P. aeruginosa from cystic fibrosis patients show high-level carbapenem resistance. • Meropenem was less active than imipenem against these…”
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Staphylococcus aureus and Cystic Fibrosis-A Close Relationship. What Can We Learn from Sequencing Studies? by Rumpf, Christine, Lange, Jonas, Schwartbeck, Bianca, Kahl, Barbara C

“…is next to the most isolated pathogen from the airways of cystic fibrosis (CF) patients, who are often infected by a dominant clone for extended periods. To be…”
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Dynamic in vivo mutations within the ica operon during persistence of Staphylococcus aureus in the airways of cystic fibrosis patients by Schwartbeck, Bianca, Birtel, Johannes, Treffon, Janina, Langhanki, Lars, Mellmann, Alexander, Kale, Devika, Kahl, Janina, Hirschhausen, Nina, Neumann, Claudia, Lee, Jean C, Götz, Friedrich, Rohde, Holger, Henke, Hanae, Küster, Peter, Peters, Georg, Kahl, Barbara C

“…Cystic fibrosis (CF) is associated with chronic bacterial airway infections leading to lung insufficiency and decreased life expectancy. Staphylococcus aureus…”
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Nuclease activity and protein A release of Staphylococcus aureus clinical isolates determine the virulence in a murine model of acute lung infection by Ludwig, Nadine, Thörner-van Almsick, Julia, Mersmann, Sina, Bardel, Bernadette, Niemann, Silke, Chasan, Achmet Imam, Schäfers, Michael, Margraf, Andreas, Rossaint, Jan, Kahl, Barbara C., Zarbock, Alexander, Block, Helena

“…Staphylococcus aureus is a common cause of hospital-acquired pneumonia associated with high mortality. Adequate clinical treatment is impeded by increasing…”
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Allergic Reactions to Serine Protease-Like Proteins of Staphylococcus aureus by Nordengrün, Maria, Abdurrahman, Goran, Treffon, Janina, Wächter, Hannah, Kahl, Barbara C, Bröker, Barbara M

“…In cystic fibrosis (CF) infectious and allergic airway inflammation cause pulmonary exacerbations that destroy the lungs. is a common long-term colonizer and…”
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Lethal Waterhouse–Friderichsen syndrome caused by Capnocytophaga canimorsus in an asplenic patient by Schuler, Franziska, Padberg, Jan-Sören, Hullermann, Carsten, Kümpers, Philipp, Lepper, Johannes, Schulte, Miriam, Uekötter, Andreas, Schaumburg, Frieder, Kahl, Barbara C

“…Abstract Background Capnocytophaga canimorsus , a Gram-negative rod, belongs to the Flavobacteriaceae family and colonizes the oropharynx of dogs and cats…”
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Lack of Sphingosine Causes Susceptibility to Pulmonary Staphylococcus Aureus Infections in Cystic Fibrosis by Tavakoli Tabazavareh, Shaghayegh, Seitz, Aaron, Jernigan, Peter, Sehl, Carolin, Keitsch, Simone, Lang, Stephan, Kahl, Barbara C., Edwards, Michael, Grassmé, Heike, Gulbins, Erich, Becker, Katrin Anne

“…Background: Pulmonary Staphylococcus aureus (S. aureus) infections occur early in a high percentage of cystic fibrosis (CF) patients and it is believed that…”
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In vivo competition and horizontal gene transfer among distinct Staphylococcus aureus lineages as major drivers for adaptational changes during long-term persistence in humans by Langhanki, Lars, Berger, Petya, Treffon, Janina, Catania, Francesco, Kahl, Barbara C, Mellmann, Alexander

“…The airways of the majority of adolescent cystic fibrosis (CF) patients are persistently colonized or infected by Staphylococcus aureus. Using whole genome…”
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High Nuclease Activity of Long Persisting Staphylococcus aureus Isolates Within the Airways of Cystic Fibrosis Patients Protects Against NET-Mediated Killing by Herzog, Susann, Dach, Felix, de Buhr, Nicole, Niemann, Silke, Schlagowski, Jannik, Chaves-Moreno, Diego, Neumann, Claudia, Goretzko, Jonas, Schwierzeck, Vera, Mellmann, Alexander, Dübbers, Angelika, Küster, Peter, Schültingkemper, Holger, Rescher, Ursula, Pieper, Dietmar H, von Köckritz-Blickwede, Maren, Kahl, Barbara C

“…is one of the first and most prevalent pathogens cultured from the airways of cystic fibrosis (CF) patients, which can persist there for extended periods…”
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Multicenter study of the performance of NTM Elite agar for the detection of nontuberculous mycobacteria from patients with cystic fibrosis by André, Emmanuel, Lorent, Natalie, Beuselinck, Kurt, Deiwick, Susanne, Dupont, Lieven, Gafsi, Johanne, Laenen, Lies, Raymaekers, Lise, Van Bleyenbergh, Pascal, Perry, John D, Kahl, Barbara C

“…The performance of a novel selective agar was evaluated against the performance of conventional mycobacterial cultures, i.e., a combination of the…”
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The Virulence Potential of Livestock-Associated Methicillin-Resistant Staphylococcus aureus Cultured from the Airways of Cystic Fibrosis Patients by Treffon, Janina, Fotiadis, Sarah Ann, van Alen, Sarah, Becker, Karsten, Kahl, Barbara C

“…is one of the most common pathogens that infects the airways of patients with cystic fibrosis (CF) and contributes to respiratory failure. Recently,…”
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Clinical and genomic features of Mycobacterium avium complex: a multi-national European study by Wetzstein, Nils, Diricks, Margo, Anton, Thomas B, Andres, Sönke, Kuhns, Martin, Kohl, Thomas A, Schwarz, Carsten, Lewin, Astrid, Kehrmann, Jan, Kahl, Barbara C, Schmidt, Annika, Zimmermann, Stefan, Jansson, Moritz K, Baron, Sophie A, Schulthess, Bettina, Hogardt, Michael, Friesen, Inna, Niemann, Stefan, Wichelhaus, Thomas A

“…The Mycobacterium avium complex (MAC) comprises the most frequent non-tuberculous mycobacteria (NTM) in Central Europe and currently includes twelve species…”
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