Search Results - "Kahana, Jason A"

AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines by Levy, Dana S., Kahana, Jason A., Kumar, Rakesh

“…The PI3K/AKT signaling is activated in various hematologic malignancies. We evaluated the effect of a novel, pan-AKT kinase inhibitor, GSK690693, on the…”
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Mechanism and Management of AKT Inhibitor-Induced Hyperglycemia by Crouthamel, Ming-Chih, Kahana, Jason A, Korenchuk, Susan, Zhang, Shu-Yun, Sundaresan, Gobalakrishnan, Eberwein, Derek J, Brown, Kathleen K, Kumar, Rakesh

“…Purpose: Insulin-like growth factor-I receptor and phosphoinositide 3-kinase/AKT/mammalian target of rapamycin pathways are among the most active areas of drug…”
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Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors by Barnett, Stanley F, Defeo-Jones, Deborah, Fu, Sheng, Hancock, Paula J, Haskell, Kathleen M, Jones, Raymond E, Kahana, Jason A, Kral, Astrid M, Leander, Karen, Lee, Ling L, Malinowski, John, McAvoy, Elizabeth M, Nahas, Debbie D, Robinson, Ronald G, Huber, Hans E

“…We developed a high-throughput HTRF (homogeneous time-resolved fluorescence) assay for Akt kinase activity and screened approx. 270000 compounds for their…”
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CENP-E as an Essential Component of the Mitotic Checkpoint In Vitro by Abrieu, Ariane, Kahana, Jason A, Wood, Kenneth W, Cleveland, Don W

“…Accurate chromatid separation is monitored by a checkpoint mechanism that delays anaphase onset until all centromeres are correctly attached to the mitotic…”
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Mutants Affecting the Structure of the Cortical Endoplasmic Reticulum in Saccharomyces cerevisiae by Prinz, William A., Grzyb, Lara, Veenhuis, Marten, Kahana, Jason A., Silver, Pamela A., Rapoport, Tom A.

“…We find that the peripheral ER in Saccharomyces cerevisiae forms a dynamic network of interconnecting membrane tubules throughout the cell cycle, similar to…”
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Use of time‐lapse microscopy to visualize rapid movement of the replication origin region of the chromosome during the cell cycle in Bacillus subtilis by Webb, Chris D., Graumann, Peter L., Kahana, Jason A., Teleman, Aurelio A., Silver, Pamela A., Losick, Richard

“…We describe the use of time‐lapse fluorescence microscopy to visualize the movement of the DNA replication origin and terminus regions on the Bacillus subtilis…”
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Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity by RHODES, Nelson, HEERDING, Dirk A, KAHANA, Jason A, GESKE, Robert S, KIEYMENOVA, Elena V, CHOUDHRY, Anthony E, ZHIHONG LAI, LEBER, Jack D, MINTHORN, Elisabeth A, STRUM, Susan L, WOOD, Edgar R, HUANG, Pearl S, DUCKETT, Derek R, COPELAND, Robert A, KUMAR, Rakesh, EBERWEIN, Derek J, KNICK, Victoria B, LANSING, Timothy J, MCCONNELL, Randy T, GILMER, Tona M, ZHANG, Shu-Yun, ROBELL, Kimberly

“…Akt kinases 1, 2, and 3 are important regulators of cell survival and have been shown to be constitutively active in a variety of human tumors. GSK690693 is a…”
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The yeast dynactin complex is involved in partitioning the mitotic spindle between mother and daughter cells during anaphase B by Kahana, J A, Schlenstedt, G, Evanchuk, D M, Geiser, J R, Hoyt, M A, Silver, P A

“…Although vertebrate cytoplasmic dynein can move to the minus ends of microtubules in vitro, its ability to translocate purified vesicles on microtubules…”
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Mps1 Is a Kinetochore-Associated Kinase Essential for the Vertebrate Mitotic Checkpoint by Abrieu, Ariane, Magnaghi-Jaulin, Laura, Kahana, Jason A., Peter, Marion, Castro, Anna, Vigneron, Suzanne, Lorca, Thierry, Cleveland, Don W., Labbé, Jean-Claude

“…The mitotic checkpoint acts to inhibit entry into anaphase until all chromosomes have successfully attached to spindle microtubules. Unattached kinetochores…”
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Beyond Nuclear Transport: Ran-GTP as a Determinant of Spindle Assembly by Kahana, Jason A., Cleveland, Don W.

“…The observation that the GTP-bound form of Ran can stimulate microtubule polymerization offers a significant insight into the process by which chromosomes…”
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Slk19p Is a Centromere Protein That Functions to Stabilize Mitotic Spindles by Zeng, Xuemei, Kahana, Jason A., Silver, Pamela A., Morphew, Mary K., McIntosh, J. Richard, Fitch, Ian T., Carbon, John, Saunders, William S.

“…We have identified a novel centromere-associated gene product from Saccharomyces cerevisiae that plays a role in spindle assembly and stability. Strains with a…”
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Tetrasubstituted pyridines as potent and selective AKT inhibitors: Reduced CYP450 and hERG inhibition of aminopyridines by Lin, Hong, Yamashita, Dennis S., Xie, Ren, Zeng, Jin, Wang, Wenyong, Leber, Jack, Safonov, Igor G., Verma, Sharad, Li, Mei, LaFrance, Louis, Venslavsky, Joseph, Takata, Dennis, Luengo, Juan I., Kahana, Jason A., Zhang, Shuyun, Robell, Kimberly A., Levy, Dana, Kumar, Rakesh, Choudhry, Anthony E., Schaber, Michael, Lai, Zhihong, Brown, Barry S., Donovan, Brian T., Minthorn, Elisabeth A., Brown, Kristin K., Heerding, Dirk A.

“…The synthesis and evaluation of tetrasubstituted aminopyridines, bearing novel azaindazole hinge binders, as potent AKT inhibitors are described. Compound 14c…”
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Some Importin News about Spindle Assembly by Kahana, Jason A., Cleveland, Don W.

“…A recent flurry of papers report that the nuclear transport proteins, importin alpha and beta, which also bind to Ran, directly regulate the activities of at…”
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Kinetics of spindle pole body separation in budding yeast by Khana, J.A. (Harvard Medical School, Boston, MA.), Schnapp, B.J, Silver, P.A

“…In the budding yeast Saccharomyces cerevisiae, the spindle pole body (SPB) serves as the microtubule-organizing center and is the functional analog of the…”
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The uses of green fluorescent protein in yeasts by Hitchcock, Amy L, Kahana, Jason A, Silver, Pamela A

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Beyond Nuclear Transport by Kahana, Jason A., Cleveland, Don W.

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Stay tuned for some importin news about spindle assembly by Marshall, Wallace F, Kahana, Jason A

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Use of the A. victoria green fluorescent protein to study protein dynamics in vivo by Kahana, J A, Silver, P A

“…Fluorescent molecules serve as valuable tools for the detection of a variety of biochemical phenomena. Such reagents have been employed for protein…”
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Use of the A. victoria green fluorescent protein to study protein dynamics in vivo by Kahana, J A, Silver, P A

“…Fluorescent molecules serve as valuable tools for the detection of a variety of biochemical phenomena. Such reagents have been employed for protein…”
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Use of the A. victoria green fluorescent protein to study protein dynamics in vivo by Kahana, J A, Silver, P A

“…Fluorescent molecules serve as valuable tools for the detection of numerous biochemical phenomena and have been employed for protein localization, quantitation…”
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