Search Results - "Kagiou, Chrysanthi"

Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation by Kagiou, Chrysanthi, Cisneros, Jose A., Farnung, Jakob, Liwocha, Joanna, Offensperger, Fabian, Dong, Kevin, Yang, Ka, Tin, Gary, Horstmann, Christina S., Hinterndorfer, Matthias, Paulo, Joao A., Scholes, Natalie S., Sanchez Avila, Juan, Fellner, Michaela, Andersch, Florian, Hannich, J. Thomas, Zuber, Johannes, Kubicek, Stefan, Gygi, Steven P., Schulman, Brenda A., Winter, Georg E.

“…Targeted protein degradation (TPD) relies on small molecules to recruit proteins to E3 ligases to induce their ubiquitylation and degradation by the…”
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Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP by Cigler, Marko, Imrichova, Hana, Frommelt, Fabian, Caramelle, Lucie, Depta, Laura, Rukavina, Andrea, Kagiou, Chrysanthi, Hannich, J Thomas, Mayor-Ruiz, Cristina, Superti-Furga, Giulio, Sievers, Sonja, Forrester, Alison, Laraia, Luca, Waldmann, Herbert, Winter, Georg E

“…Metabolic alterations in cancer precipitate in associated dependencies that can be therapeutically exploited. To meet this goal, natural product-inspired small…”
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