Search Results - "Kagimu, Enock"

Xpert MTB/RIF Ultra for the diagnosis of HIV-associated tuberculous meningitis: a prospective validation study by Cresswell, Fiona V, Tugume, Lillian, Bahr, Nathan C, Kwizera, Richard, Bangdiwala, Ananta S, Musubire, Abdu K, Rutakingirwa, Morris, Kagimu, Enock, Nuwagira, Edwin, Mpoza, Edward, Rhein, Joshua, Williams, Darlisha A, Muzoora, Conrad, Grint, Daniel, Elliott, Alison M, Meya, David B, Boulware, David R

“…Tuberculous meningitis accounts for 1–5% of tuberculosis cases. Diagnostic delay contributes to poor outcomes. We evaluated the performance of the new Xpert…”
Get full text

Complex Decisions in HIV-Related Cryptococcosis: Addressing Second Episodes of Cryptococcal Meningitis by Musubire, Abdu, Kagimu, Enock, Mugabi, Timothy, Meya, David B., Boulware, David R., Bahr, Nathan C.

“…Purpose of Review This review highlights the difficulties in diagnosing and treating persons with a prior history of cryptococcal meningitis who improve but…”
Get full text

Cerebrospinal Fluid Bacillary Load by Xpert MTB/RIF Ultra Polymerase Chain Reaction Cycle Threshold Value Predicts 2-Week Mortality in Human Immunodeficiency Virus–Associated Tuberculous Meningitis by Martyn, Emily M, Bangdiwala, Ananta S, Kagimu, Enock, Rutakingirwa, Morris K, Kasibante, John, Okirwoth, Michael, Stead, Gavin, Wadda, Vincent, Pullen, Matthew F, Bold, Tyler D, Meya, David B, Boulware, David R, Bahr, Nathan C, Cresswell, Fiona V

“…Abstract Background The World Health Organization recommends GeneXpert MTB/RIF Ultra (Xpert Ultra), a fully automated polymerase chain reaction (PCR) assay, as…”
Get full text

Advancing Diagnosis and Treatment in People Living with HIV and Tuberculosis Meningitis by Kimuda, Sarah, Kasozi, Derrick, Namombwe, Suzan, Gakuru, Jane, Mugabi, Timothy, Kagimu, Enock, Rutakingirwa, Morris K., Leon, Kristoffer E., Chow, Felicia, Wasserman, Sean, Boulware, David R., Cresswell, Fiona V., Bahr, Nathan C.

“…Purpose of review Tuberculous meningitis (TBM) is the most severe form of tuberculosis. Inadequate diagnostic testing and treatment regimens adapted from…”
Get full text

Evaluation of the initial 12 months of a routine cryptococcal antigen screening program in reduction of HIV-associated cryptococcal meningitis in Uganda by Enock, Kagimu, Julius, Kiwanuka, Griffith, Bridget C, Abila, Derrick Bary, Rutakingirwa, Morris K, Kasibante, John, Kandole, Kiiza Tadeo, Kwizera, Richard, Semeere, Aggrey, Meya, David B

“…Asymptomatic Cryptococcal Antigenemia (CrAg) patients develop meningitis within a month of testing positive. Pre-emptive antifungal therapy can prevent…”
Get full text

Distal jejunal obstruction due to Cryptococcus neoformans and rifampicin-resistant Mycobacterium tuberculosis co-infection: A case report by Kasibante, John, Kagimu, Enock, Rutakingirwa, Morris K., Jjunju, Samuel, Tugume, Lillian, Meya, David B.

“…Jejunal obstruction secondary to Cryptococcus neoformans and rifampicin-resistant Mycobacterium tuberculosis co-infection in HIV is not previously reported…”
Get full text

Clinical characteristics and morbidity among hospitalized adults with advanced HIV disease in Uganda during 'test and treat' era by Tugume, Lillian, Semitala, Fred C, Owachi, Darius, Kagimu, Enock, Kamya, Moses R, Meya, David B

“…Nearly four decades after the first case of AIDS was described, the global number of AIDS-related deaths has steadily declined but falls short of the…”
Get full text

Diagnostic and Prognostic Value of Cerebrospinal Fluid Lactate and Glucose in HIV-Associated Tuberculosis Meningitis by Nuwagira, Edwin, Huppler Hullsiek, Kathy, Jjunju, Samuel, Rutakingirwa, Morris, Kasibante, John, Tadeo, Kiiza Kandole, Kagimu, Enock, Tugume, Lillian, Ssebambulidde, Kenneth, Musubire, Abdu K., Bangdiwala, Ananta, Muzoora, Conrad, Meya, David B., Boulware, David R., Bahr, Nathan C., Creswell, Fiona V.

“…The role of cerebrospinal fluid (CSF) lactate in tuberculosis meningitis (TBM) diagnosis and prognosis is unclear. The aim of this study was to evaluate the…”
Get full text

Tuberculosis in HIV-Associated Cryptococcal Meningitis is Associated with an Increased Risk of Death by Rutakingirwa, Morris K, Cresswell, Fiona V, Kwizera, Richard, Ssebambulidde, Kenneth, Kagimu, Enock, Nuwagira, Edwin, Tugume, Lillian, Mpoza, Edward, Dobbin, Joanna, Williams, Darlisha A, Muzoora, Conrad, Meya, David B, Boulware, David R, Hullsiek, Kathy H, Rhein, Joshua

“…Tuberculosis (TB) and cryptococcal meningitis are leading causes of morbidity and mortality in advanced HIV disease. Data are limited on TB co-infection among…”
Get full text

Integrated management of cryptococcal meningitis and concurrent opportunistic infections to improve outcomes in advanced HIV disease: a randomised strategy trial by Ellis, Jayne, Nsangi, Laura, Bangdiwala, Ananta, Hale, Gila, Gakuru, Jane, Kagimu, Enock, Mugabi, Timothy, Kigozi, Enos, Tukundane, Asmus, Okirwoth, Michael, Kandole, Tadeo Kiiza, Cresswel, Fiona, Harrison, Thomas S, Moore, David, Fielding, Katherine, Meya, David, Boulware, David, Jarvis, Joseph N

“…Mortality associated with HIV-associated cryptococcal meningitis remains high even in the context of clinical trials (24-45% at 10 weeks); mortality at…”
Get full text

Recent Developments in Tuberculous Meningitis Pathogenesis and Diagnostics by Cresswell, Fiona V, Davis, Angharad G., Sharma, Kusum, Basu Roy, Robindra, Ganiem, Ahmad Rizal, Kagimu, Enock, Solomons, Regan, Wilkinson, Robert J., Bahr, Nathan C, Thuong, Nguyen Thuy Thuong

“…The pathogenesis of Tuberculous meningitis (TBM) is poorly understood, but contemporary molecular biology technologies have allowed for recent improvements in…”
Get full text

Tuberculosis preventive therapy (TPT) to prevent tuberculosis co-infection among adults with HIV-associated cryptococcal meningitis: A clinician’s perspective by Kasibante, John, Rutakingirwa, Morris K., Kagimu, Enock, Ssebambulidde, Kenneth, Ellis, Jayne, Tugume, Lillian, Mpoza, Edward, Cresswell, Fiona, Meya, David B.

“…As part of the END TB strategy, the World Health organization (WHO) recommends provision of tuberculosis preventive therapy (TPT) to all people at high risk of…”
Get full text

Performance of Lipoarabinomannan Assay using Cerebrospinal fluid for the diagnosis of Tuberculous meningitis among HIV patients by Kwizera, Richard, Cresswell, Fiona V, Mugumya, Gerald, Okirwoth, Micheal, Kagimu, Enock, Bangdiwala, Ananta S, Williams, Darlisha A, Rhein, Joshua, Boulware, David R, Meya, David B

“…The diagnostic utility of the lipoarabinomannan (TB-LAM) antigen lateral flow assay on cerebrospinal fluid (CSF) for the diagnosis of tuberculous meningitis…”
Get full text

High dose oral rifampicin to improve survival from adult tuberculous meningitis: A randomised placebo-controlled double-blinded phase III trial (the HARVEST study) by Marais, Suzaan, Cresswell, Fiona V, Hamers, Raph L., te Brake, Lindsey H.M., Ganiem, Ahmad R., Imran, Darma, Bangdiwala, Ananta, Martyn, Emily, Kasibante, John, Kagimu, Enock, Musubire, Abdu, Maharani, Kartika, Estiasari, Riwanti, Kusumaningrum, Ardiana, Kusumadjayanti, Nadytia, Yunivita, Vycke, Naidoo, Kogieleum, Lessells, Richard, Moosa, Yunus, Svensson, Elin M., Huppler Hullsiek, Katherine, Aarnoutse, Rob E., Boulware, David R., van Crevel, Reinout, Ruslami, Rovina, Meya, David B.

“…Background: Tuberculous meningitis (TBM), the most severe form of tuberculosis (TB), results in death or neurological disability in >50%, despite World Health…”
Get full text

Performance of Lipoarabinomannan Assay using Cerebrospinal fluid for the diagnosis of Tuberculous meningitis among HIV patients by Kwizera, Richard, Cresswell, Fiona V., Mugumya, Gerald, Okirwoth, Micheal, Kagimu, Enock, Bangdiwala, Ananta S., Williams, Darlisha A., Rhein, Joshua, Boulware, David R., Meya, David B.

“…Background: The diagnostic utility of the Mycobacteria tuberculosis lipoarabinomannan (TB-LAM) antigen lateral flow assay on cerebrospinal fluid (CSF) for the…”
Get full text

Recent Developments in Tuberculous Meningitis Pathogenesis and Diagnostics by Cresswell, Fiona V, Davis, Angharad G., Sharma, Kusum, Basu Roy, Robindra, Ganiem, Ahmad Rizal, Kagimu, Enock, Solomons, Regan, Wilkinson, Robert J., Bahr, Nathan C, Thuong, Nguyen Thuy Thuong

“…The pathogenesis of Tuberculous meningitis (TBM) is poorly understood, but contemporary molecular biology technologies have allowed for recent improvements in…”
Get full text

Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis by Jarvis, Joseph N, Lawrence, David S, Meya, David B, Kagimu, Enock, Kasibante, John, Mpoza, Edward, Rutakingirwa, Morris K, Ssebambulidde, Kenneth, Tugume, Lillian, Rhein, Joshua, Boulware, David R, Mwandumba, Henry C, Moyo, Melanie, Mzinganjira, Henry, Kanyama, Cecilia, Hosseinipour, Mina C, Chawinga, Chimwemwe, Meintjes, Graeme, Schutz, Charlotte, Comins, Kyla, Singh, Achita, Muzoora, Conrad, Jjunju, Samuel, Nuwagira, Edwin, Mosepele, Mosepele, Leeme, Tshepo, Siamisang, Keatlaretse, Ndhlovu, Chiratidzo E, Hlupeni, Admire, Mutata, Constantine, van Widenfelt, Erik, Chen, Tao, Wang, Duolao, Hope, William, Boyer-Chammard, Timothée, Loyse, Angela, Molloy, Síle F, Youssouf, Nabila, Lortholary, Olivier, Lalloo, David G, Jaffar, Shabbar, Harrison, Thomas S

“…Cryptococcal meningitis is a major complication of HIV infection. In this phase 3, randomized, controlled trial in sub-Saharan Africa, a single dose of…”
Get full text

High-Dose Oral and Intravenous Rifampicin for the Treatment of Tuberculous Meningitis in Predominantly Human Immunodeficiency Virus (HIV)-Positive Ugandan Adults: A Phase II Open-Label Randomized Controlled Trial by Cresswell, Fiona V, Meya, David B, Kagimu, Enock, Grint, Daniel, te Brake, Lindsey, Kasibante, John, Martyn, Emily, Rutakingirwa, Morris, Quinn, Carson M, Okirwoth, Micheal, Tugume, Lillian, Ssembambulidde, Kenneth, Musubire, Abdu K, Bangdiwala, Ananta S, Buzibye, Allan, Muzoora, Conrad, Svensson, Elin M, Aarnoutse, Rob, Boulware, David R, Elliott, Alison M

“…Abstract Background High-dose rifampicin may improve outcomes of tuberculous meningitis (TBM). Little safety or pharmacokinetic (PK) data exist on high-dose…”
Get full text

Evaluation of the Dynamiker Cryptococcal Antigen Lateral Flow Assay for the Diagnosis of HIV-Associated Cryptococcosis by Kwizera, Richard, Omali, Denis, Tadeo, Kiiza, Kasibante, John, Rutakingirwa, Morris K, Kagimu, Enock, Ssebambulidde, Kenneth, Williams, Darlisha A, Rhein, Joshua, Boulware, David, Meya, David B

“…Cryptococcal meningitis is a leading cause of meningitis in sub-Saharan Africa. Given the need for rapid point-of-care testing, we evaluated the diagnostic…”
Get full text

Fujifilm SILVAMP TB LAM Assay on Cerebrospinal Fluid for the Detection of Tuberculous Meningitis in Adults With Human Immunodeficiency Virus by Quinn, Carson M, Kagimu, Enock, Okirworth, Michael, Bangdiwala, Ananta S, Mugumya, Gerald, Ramachandran, Prashanth S, Wilson, Michael R, Meya, David B, Cresswell, Fiona V, Bahr, Nathan C, Boulware, David R

“…Abstract Background Tuberculous meningitis (TBM) has a high fatality rate, with inadequate diagnostic tests being a major contributor. The rollout of Xpert…”
Get full text