Search Results - "Kagel, J.R."

Development of a chiral HPLC method to evaluate in vivo enantiomeric inversion of an unstable, polar radiosensitizer in plasma by Kagel, J.R, Rossi, D.T, Hoffman, K.L, Leja, B, Lathia, C.D

“…A chiral HPLC method to quantify in vivo enantiomeric inversion of prodrug CI-1010 ( I R ) or its drug II R (PD 146923), a radiosensitizer, upon X-irradiation…”
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Management of nonmatrix interfering peaks in a chiral high-performance liquid chromatographic assay produced by solid-phase extraction of rat plasma by Kagel, J.R., Rossi, D.T., Lathia, C.D.

“…PD 146923, under evaluation as an alkylating radiosensitizing drug, contains one chiral center and one chemically reactive aziridine ring. A method was…”
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Improving ion-trap GC-MS quantitation limits for therapeutic agents extracted from rat plasma by Kagel, J.R, Grove, C.A, Rossi, D.T

“…Insufficient quantitation limits using ion-trap gas-chromatography mass-spectrometry (GC-MS) prevented the assay of some samples during a preliminary screening…”
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