Search Results - "Kagan, V.E."

Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction? by Stoyanovsky, D.A., Tyurina, Y.Y., Shrivastava, I., Bahar, I., Tyurin, V.A., Protchenko, O., Jadhav, S., Bolevich, S.B., Kozlov, A.V., Vladimirov, Y.A., Shvedova, A.A., Philpott, C.C., Bayir, H., Kagan, V.E.

“…Duality of iron as an essential cofactor of many enzymatic metabolic processes and as a catalyst of poorly controlled redox-cycling reactions defines its…”
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Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes by Murray, A.R, Kisin, E, Leonard, S.S, Young, S.H, Kommineni, C, Kagan, V.E, Castranova, V, Shvedova, A.A

“…Abstract Single-walled carbon nanotubes (SWCNT) represent a novel material with unique electronic and mechanical properties. The extremely small size (∼1 nm…”
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Mechanisms of pulmonary toxicity and medical applications of carbon nanotubes: Two faces of Janus? by Shvedova, A A, Kisin, E R, Porter, D, Schulte, P, Kagan, V E, Fadeel, B, Castranova, V

“…Nanotechnology is an emerging science involving manipulation of materials at the nanometer scale. There are several exciting prospects for the application of…”
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Redox phospholipidomics of enzymatically generated oxygenated phospholipids as specific signals of programmed cell death by Kagan, V.E., Tyurina, Y.Y., Sun, W.Y., Vlasova, I.I., Dar, H., Tyurin, V.A., Amoscato, A.A., Mallampalli, R., van der Wel, P.C.A., He, R.R., Shvedova, A.A., Gabrilovich, D.I., Bayir, H.

“…High fidelity and effective adaptive changes of the cell and tissue metabolism to changing environments require strict coordination of numerous biological…”
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Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: Role of iron by Kagan, V.E., Tyurina, Y.Y., Tyurin, V.A., Konduru, N.V., Potapovich, A.I., Osipov, A.N., Kisin, E.R., Schwegler-Berry, D., Mercer, R., Castranova, V., Shvedova, A.A.

“…Single-walled carbon nanotubes (SWCNT), nano-cylinders with an extremely small diameter (1–2 nm) and high aspect ratio, have unique physico-chemical,…”
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Formation of protein adducts with Hydroperoxy-PE electrophilic cleavage products during ferroptosis by Amoscato, A.A., Anthonymuthu, T., Kapralov, O., Sparvero, L.J., Shrivastava, I.H., Mikulska-Ruminska, K., Tyurin, V.A., Shvedova, A.A., Tyurina, Y.Y., Bahar, I., Wenzel, S., Bayir, H., Kagan, V.E.

“…Ferroptosis is an iron dependent form of cell death, that is triggered by the discoordination of iron, lipids, and thiols. Its unique signature that…”
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Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes by Shvedova, A.A., Kisin, E.R., Murray, A.R., Kommineni, C., Castranova, V., Fadeel, B., Kagan, V.E.

“…Single-walled carbon nanotubes (SWCNT) have been introduced into a large number of new technologies and consumer products. The combination of their exceptional…”
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Identification of Ionizing Irradiation Damage Mitigators by Evaluation of Clonogenic Survival of Human Umbilical Cord Blood Progenitor Cells by Goff, J, Shields, D, Wang, H, Skoda, E, Sprachman, M, Wipf, P, Atkinson, J, Epperly, M, Kagan, V.E, Lazo, J.S

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Binding of fatty acids facilitates oxidation of cysteine-34 and converts copper–albumin complexes from antioxidants to prooxidants by Gryzunov, Y.A., Arroyo, A., Vigne, J.-L., Zhao, Q., Tyurin, V.A., Hubel, C.A., Gandley, R.E., Vladimirov, Y.A., Taylor, R.N., Kagan, V.E.

“…As a transition metal capable of undergoing one-electron oxidation–reduction conversions, copper (Cu) is essential for life and fulfills important catalytic…”
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Potentially Lethal Damage Repair is Enhanced by the Mitochondria-targeted Nitroxide JP4-039 by Rajagopalan, M.S, Gupta, K, Epperly, M.W, Franicola, D, Zhang, X, Wang, H, Kagan, V.E, Wipf, P, Kanai, A, Greenberger, J.S

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Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity by SCHWARZ, M. A, LAZO, J. S, YALOWICH, J. C, REYNOLDS, I, KAGAN, V. E, TYURIN, V, YOUNG-MYEONG KIM, WATKINS, S. C, PITT, B. R

“…Metallothioneins (MT) are ubiquitous low molecular weight metal-binding proteins that may act as antioxidants. We examined the sensitivity of NIH 3T3 cells…”
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811 UVB initiates skin inflammation by promoting keratinocyte ferroptosis by Vats, K., Kruglov, O., Mizes, A., Samovich, S.N., Amoscato, A.A., Tyurin, V.A., Tyurina, Y.Y., Kagan, V.E., Bunimovich, Y.L.

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Antiradical effects in L-propionyl carnitine protection of the heart against ischemia-reperfusion injury: the possible role of iron chelation by Reznick, A Z, Kagan, V E, Ramsey, R, Tsuchiya, M, Khwaja, S, Serbinova, E A, Packer, L

“…L-Propionyl carnitine has been shown to improve the heart's mechanical recovery and other metabolic parameters after ischemia-reperfusion. However, the…”
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Interrogating Parkinson's disease associated redox targets: Potential application of CRISPR editing by Artyukhova, M.A., Tyurina, Y.Y., Chu, C.T., Zharikova, T.M., Bayır, H., Kagan, V.E., Timashev, P.S.

“…Loss of dopaminergic neurons in the substantia nigra is one of the pathogenic hallmarks of Parkinson's disease, yet the underlying molecular mechanisms remain…”
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Enhanced morphological transformation of human lung epithelial cells by continuous exposure to cellulose nanocrystals by Kisin, E.R., Yanamala, N., Rodin, D., Menas, A., Farcas, M., Russo, M., Guppi, S., Khaliullin, T.O., Iavicoli, I., Harper, M., Star, A., Kagan, V.E., Shvedova, A.A.

“…Cellulose nanocrystals (CNC), also known as nanowhiskers, have recently gained much attention due to their biodegradable nature, advantageous chemical and…”
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Imaging mass spectrometry reveals loss of polyunsaturated cardiolipins in the cortical contusion, hippocampus, and thalamus after traumatic brain injury by Sparvero, Louis J., Amoscato, Andrew A., Fink, Arthur B., Anthonymuthu, Tamil, New, Lee Ann, Kochanek, Patrick M., Watkins, Simon, Kagan, Valerian E., Bayır, Hulya

“…Traumatic brain injury (TBI) leads to changes in ion fluxes, alterations in mitochondrial function, and increased generation of reactive oxygen species,…”
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Genotoxicity of carbon nanofibers: Are they potentially more or less dangerous than carbon nanotubes or asbestos? by Kisin, E.R., Murray, A.R., Sargent, L., Lowry, D., Chirila, M., Siegrist, K.J., Schwegler-Berry, D., Leonard, S., Castranova, V., Fadeel, B., Kagan, V.E., Shvedova, A.A.

“…The production of carbon nanofibers and nanotubes (CNF/CNT) and their composite products is increasing globally. CNF are generating great interest in…”
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Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations by Sparvero, Louis J., Amoscato, Andrew A., Dixon, C. Edward, Long, Joseph B., Kochanek, Patrick M., Pitt, Bruce R., Bayır, Hülya, Kagan, Valerian E.

“…► Mapping of lipids by MALDI-MSI. ► Biochemical microscopy of DHA-containing lipids. ► MALDI-MSI of lipid oxidation products in acute lung injury. ► MALDI-MSI…”
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Magic angle spinning 31P NMR spectroscopy reveals two essentially identical ionization states for the cardiolipin phosphates in phospholipid liposomes by Kooijman, E.E., Swim, L.A., Graber, Z.T., Tyurina, Y.Y, Bayır, H., Kagan, V.E.

“…Specific membrane lipid composition is crucial for optimized structural and functional organization of biological membranes. Cardiolipin is a unique…”
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Improved Spatial Resolution of MALDI Imaging of Lipids in the Brain by Alkylated Derivatives of 2,5-Dihydroxybenzoic Acid by Stoyanovsky, D.A., Sparvero, L.J., Amoscato, A.A., He, R.R., Watkins, S., Pitt, B.R., Bayir, H., Kagan, V.E.

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