Search Results - "Kagan, Mark"

Immunogenicity assessment strategy for a chemically modified therapeutic protein in clinical development by Hagman, Charlotte, Chasseigne, Gaetan, Nelson, Robert, Anlauff, Florian, Kagan, Mark, Goldfine, Allison B., Terszowski, Grzegorz, Jadhav, Maria

“…The clinical immunogenicity assessment for complex multidomain biological drugs is challenging due to multiple factors that must be taken into consideration…”
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A growth-differentiation factor 15 receptor agonist in randomized placebo-controlled trials in healthy or obese persons by Smith, William B, Nguyen, David, Clough, Timothy, Schofield, Jül, Kagan, Mark R, Kompa, Jill, He, YanLing, Maratos-Flier, Eleftheria, Jamontt, Joanna, Vong, Linh, Schwartzkopf, Chad D, Layne, Joseph D, Usera, Aimee R, O'Donnell, Christopher J, Heldwein, Kurt A, Streeper, Ryan S, Goldfine, Allison B

“…Growth Differentiation Factor 15 (GDF15), a divergent member of the TGF-β superfamily, signals via the hindbrain glial-derived neurotrophic factor receptor…”
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Reduction of Fluorescence Interference in Raman Spectroscopy via Analyte Adsorption on Graphitic Carbon by Kagan, Mark R, McCreery, Richard L

“…Raman spectra of normally fluorescent materials were obtained by quenching the fluorescence through adsorption on carbon surfaces. Strong resonance enhancement…”
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Quantitative Surface Raman Spectroscopy of Physisorbed Monolayers on Glassy Carbon by Kagan, Mark R, McCreery, Richard L

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A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the "Metabolites in Safety Testing" Regulatory Guidance by Schadt, Simone, Bister, Bojan, Chowdhury, Swapan K, Funk, Christoph, Hop, Cornelis E C A, Humphreys, W Griffith, Igarashi, Fumihiko, James, Alexander D, Kagan, Mark, Khojasteh, S Cyrus, Nedderman, Angus N R, Prakash, Chandra, Runge, Frank, Scheible, Holger, Spracklin, Douglas K, Swart, Piet, Tse, Susanna, Yuan, Josh, Obach, R Scott

“…Since the introduction of metabolites in safety testing (MIST) guidance by the Food and Drug Administration in 2008, major changes have occurred in the…”
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Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1-mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependence of Tropifexor Metabolism by Wang-Lakshman, Lydia, Miao, Zhuang, Wang, Lai, Gu, Helen, Kagan, Mark, Gu, Jessie, McNamara, Elizabeth, Walles, Markus, Woessner, Ralph, Camenisch, Gian, Einolf, Heidi J, Chen, Jin

“…Tropifexor (NVP-LJN452) is a highly potent, selective, nonsteroidal, non-bile acid farnesoid X receptor agonist for the treatment of nonalcoholic…”
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Metabolism and pharmacokinetics of indacaterol in humans by Kagan, Mark, Dain, Jeremy, Peng, Lana, Reynolds, Christine

“…The metabolism, pharmacokinetics, and excretion of [(14)C]indacaterol were investigated in healthy male subjects. Although indacaterol is administered to…”
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Immunoprecipitation middle-up LC-MS for in vivo drug-to-antibody ratio determination for antibody-drug conjugates by Davis, John A, Kagan, Mark, Read, Jessica, Walles, Markus, Hatsis, Panos

“…Drug-to-antibody ratio (DAR) determination is critical for development of antibody-drug conjugates (ADCs). This work presents a middle-up LC-MS approach for…”
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Battle for Climate and Scarcity Rents: Beyond the Linear-Quadratic Case by Kagan, Mark, van der Ploeg, Frederick, Withagen, Cees

“…Industria imports oil, produces final goods and wishes to mitigate global warming. Oilrabia exports oil and buys final goods from the other country. Industria…”
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Immunoprecipitation middle-up LC-MS for by Davis, John A, Kagan, Mark, Read, Jessica, Walles, Markus, Hatsis, Panos

“…Drug-to-antibody ratio (DAR) determination is critical for development of antibody-drug conjugates (ADCs). This work presents a middle-up LC-MS approach for…”
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Clinical and Preclinical Characterisation Of The Metabolites Of The BCR-ABL Tyrosine Kinase Inhibitor Nilotinib by Manley, Paul W., Mestan, Jürgen, Sheng, Jennifer, Tran, Phi, Kagan, Mark

“…There is a growing tendency for drugs to be grouped according to their perceived ‘class effects', regardless of the different pharmacological profiles of the…”
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Characterizing the disposition, metabolism, and excretion of an orally active pan-deacetylase inhibitor, panobinostat, via trace radiolabeled 14C material in advanced cancer patients by Clive, Sally, Woo, Margaret M., Nydam, Thomas, Kelly, Lindsay, Squier, Margaret, Kagan, Mark

“…Purpose Elucidating the metabolic profile of anticancer agent panobinostat is essential during drug development. Disposition, metabolism, and excretion…”
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Characterizing the disposition, metabolism, and excretion of an orally active pan-deacetylase inhibitor, panobinostat, via trace radiolabeled super(14)C material in advanced cancer patients by Clive, Sally, Woo, Margaret M, Nydam, Thomas, Kelly, Lindsay, Squier, Margaret, Kagan, Mark

“…Purpose: Elucidating the metabolic profile of anticancer agent panobinostat is essential during drug development. Disposition, metabolism, and excretion…”
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Characterizing the disposition, metabolism, and excretion of an orally active pan-deacetylase inhibitor, panobinostat, via trace radiolabeled ^sup 14^C material in advanced cancer patients by Clive, Sally, Woo, Margaret M, Nydam, Thomas, Kelly, Lindsay, Squier, Margaret, Kagan, Mark

“…Elucidating the metabolic profile of anticancer agent panobinostat is essential during drug development. Disposition, metabolism, and excretion profiles were…”
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Evaluation of food effect on the oral bioavailability of pradigastat, a diacylglycerol acyltransferase 1 inhibitor by Ayalasomayajula, Surya P., Meyers, Charles D., Yu, Jing, Kagan, Mark, Matott, Ralph, Pal, Parasar, Majumdar, Tapan, Su, Zhenzhong, Crissey, Anne, Rebello, Sam, Sunkara, Gangadhar, Chen, Jin

“…Pradigastat, a diacylglycerol acyltransferase 1 inhibitor, is being developed for the treatment of familial chylomicronemia syndrome. The results of two…”
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Determination of the urinary benzene metabolites S-phenylmercapturic acid and trans,trans-muconic acid by liquid chromatography-tandem mass spectrometry by Melikian, Assieh A., O'Connor, Ray, Prahalad, Agasanur K., Hu, Peifeng, Li, Heyi, Kagan, Mark, Thompson, Seth

“…To investigate how various levels of exposure affect the metabolic activation pathways of benzene in humans and to examine the relationship between urinary…”
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Safety, Pharmacokinetics (PK), Metabolism, and Mass Balance of [14C]-AMN107, a Novel Aminopyrimidine Inhibitor of Bcr-Abl Tyrosine Kinase, in Healthy Subjects by Kagan, Mark, Tran, Phi, Fischer, Volker, Savage, Paula, Smith, Tom, Tanaka, Chiaki, Schran, Horst, Narurkar, Milind, Alland, Leila

“…Background: AMN107, a selective and potent inhibitor of Bcr-Abl tyrosine kinase signaling, has demonstrated activity against imatinib resistant forms of…”
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Validation of biomarkers in humans exposed to benzene: Urine metabolites by Qu, Qingshan, Melikian, Assieh A., Li, Guilan, Shore, Roy, Chen, Lungchi, Cohen, Beverly, Yin, Songnian, Kagan, Mark R., Li, Heyi, Meng, Min, Jin, Ximei, Winnik, Witold, Li, Yuying, Mu, Ruidong, Li, Keqi

“…Background The present study was conducted among Chinese workers employed in glue‐ and shoe‐making factories who had an average daily personal benzene exposure…”
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Raman spectroscopy of organic molecules physisorbed onto graphitic carbon surfaces by Kagan, Mark Richard

“…The utility of Raman spectroscopy for studying organic molecules physisorbed onto various graphitic carbon surfaces was explored. A solution phase procedure…”
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Analysis of 1,3-butadiene and other selected gas-phase components in cigarette mainstream and sidestream smoke by gas chromatography-mass selective detection by Brunnemann, K D, Kagan, M R, Cox, J E, Hoffmann, D

“…An analytical procedure was developed for the analysis of 1,3-butadiene, acrolein, isoprene, benzene and toluene in the gas phase of cigarette smoke and…”
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