Search Results - "Kaemmerer, Elke"

Functionalization, preparation and use of cell-laden gelatin methacryloyl–based hydrogels as modular tissue culture platforms by Loessner, Daniela, Meinert, Christoph, Kaemmerer, Elke, Martine, Laure C, Yue, Kan, Levett, Peter A, Klein, Travis J, Melchels, Ferry P W, Khademhosseini, Ali, Hutmacher, Dietmar W

“…This protocol describes how to make semisynthetic gelatin methacryloyl (GelMA)-based hydrogels for use in 3D cell culture models for cancer research, stem cell…”
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TRPC1 is a differential regulator of hypoxia-mediated events and Akt signalling in PTEN-deficient breast cancer cells by Azimi, Iman, Milevskiy, Michael J G, Kaemmerer, Elke, Turner, Dane, Yapa, Kunsala T D S, Brown, Melissa A, Thompson, Erik W, Roberts-Thomson, Sarah J, Monteith, Gregory R

“…Hypoxia is a feature of the tumour microenvironment that promotes invasiveness, resistance to chemotherapeutics and cell survival. Our studies identify the…”
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Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action by Krohne, Tim U., Kaemmerer, Elke, Holz, Frank G., Kopitz, Jürgen

“…In age-related macular degeneration (AMD), reduced lysosomal capacity may contribute to lipofuscinogenesis and progressive dysfunction of the retinal pigment…”
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Hemophagocytosis of the Hilar Pulmonary Lymph Nodes Is a More Sensitive Indicator of the Severity of COVID-19 Disease than Bone Marrow Hemophagocytosis by Jusovic-Stocanin, Amira, Kaemmerer, Elke, Ihle, Hannah, Autsch, Angelina, Kleemann, Sandra, Sanft, Juliane, Hubig, Michael, Mall, Gita, Gassler, Nikolaus

“…In systemic hyper-inflammation, as in severe COVID-19 disease, there are pronounced disorders of the hematological and lymphatic systems with prognostically…”
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Effects of Lipid Peroxidation-Related Protein Modifications on RPE Lysosomal Functions and POS Phagocytosis by Kaemmerer, Elke, Schutt, Florian, Krohne, Tim U, Holz, Frank G, Kopitz, Jurgen

“…Lipofuscin accumulation in the RPE is a common downstream pathogenic pathway in various monogenic and complex retinal diseases including age-related macular…”
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Modulating effects of acyl-CoA synthetase 5-derived mitochondrial Wnt2B palmitoylation on intestinal Wnt activity by Klaus, Christina, Schneider, Ursula, Hedberg, Christian, Schütz, Anke K, Bernhagen, Jürgen, Waldmann, Herbert, Gassler, Nikolaus, Kaemmerer, Elke

“…AIM:To investigate the role of acyl-CoA synthetase 5(ACSL5)activity in Wnt signaling in intestinal surface epithelia.METHODS:Several cell lines were used to…”
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Beta-7 integrin controls enterocyte migration in the small intestine by Kaemmerer, Elke, Kuhn, Paula, Schneider, Ursula, Clahsen, Thomas, Jeon, Min Kyung, Klaus, Christina, Andruszkow, Julia, Härer, Michael, Ernst, Sabine, Schippers, Angela, Wagner, Norbert, Gassler, Nikolaus

“…AIM:To hypothesize that beta-7 integrin affects cellularmigration of both,lymphocytes and enterocytes.METHODS:The nucleoside analog Brd U was ip injected in…”
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Modifier-concept of colorectal carcinogenesis: Lipidomics as a technical tool in pathway analysis by Gassler, Nikolaus, Klaus, Christina, Kaemmerer, Elke, Reinartz, Andrea

“…In the modifier concept of intestinal carcinogenesis, lipids have been established as important variables and one focus is given to long-chain fatty acids…”
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Human intestinal acyl-CoA synthetase 5 is sensitive to the inhibitor triacsin C by Kaemmerer, Elke, Peuscher, Anne, Reinartz, Andrea, Liedtke, Christian, Weiskirchen, Ralf, Kopitz, Jürgen, Gassler, Nikolaus

“…AIM：To investigate whether human acyl-CoA synthetase 5（ACSL5） is sensitive to the ACSL inhibitor triacsin C.METHODS：The ACSL isoforms ACSL1 and ACSL5 from rat…”
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Intestinal barrier:Molecular pathways and modifiers by Jeon, Min Kyung, Klaus, Christina, Kaemmerer, Elke, Gassler, Nikolaus

“…The gastrointestinal tract is frequently challenged by pathogens/antigens contained in food and water and the intestinal epithelium must be capable of rapid…”
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Addressing the tumour microenvironment in early drug discovery: a strategy to overcome drug resistance and identify novel targets for cancer therapy by Kaemmerer, Elke, Loessner, Daniela, Avery, Vicky M.

“…•Changes in the microenvironment (TME) promote drug resistance.•Cellular composition, biochemical and -biophysical parameters create tissue-specific…”
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Wnt Lipidation and Modifiers in Intestinal Carcinogenesis and Cancer by Kaemmerer, Elke, Gassler, Nikolaus

“…The wingless (Wnt) signaling is suggested as a fundamental hierarchical pathway in regulation of proliferation and differentiation of cells. The Wnt ligands…”
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Ileocecal Intussusception with Histomorphological Features of Inflammatory Neuropathy in Adenovirus Infection by Kaemmerer, Elke, Tischendorf, Jens J. W., Steinau, Gerd, Wagner, Norbert, Gassler, Nikolaus

“…The pathophysiological mechanisms for ileocecal intussusception in children with adenovirus infection are not well characterized. Here we demonstrate…”
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Gelatine methacrylamide-based hydrogels: An alternative three-dimensional cancer cell culture system by Kaemmerer, Elke, Melchels, Ferry P.W., Holzapfel, Boris M., Meckel, Tobias, Hutmacher, Dietmar W., Loessner, Daniela

“…Modern cancer research requires physiological, three-dimensional (3-D) cell culture platforms, wherein the physical and chemical characteristics of the…”
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Fatty acid binding receptors in intestinal physiology and pathophysiology by Kaemmerer, Elke, Plum, Patrick, Klaus, Christina, Weiskirchen, Ralf, Liedtke, Christian, Adolf, Maximilian, Schippers, Angela, Wagner, Norbert, Reinartz, Andrea, Gassler, Nikolaus

“…Free fatty acids are essential dietary components and recognized as important molecules in the maintenance of cellular homeostasis.In the last decade,the…”
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Fatty acid metabolism and acyl-CoA synthetases in the liver-gut axis by Ma, Yunxia, Nenkov, Miljana, Chen, Yuan, Press, Adrian T, Kaemmerer, Elke, Gassler, Nikolaus

“…Fatty acids are energy substrates and cell components which participate in regulating signal transduction, transcription factor activity and secretion of…”
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Targeting Wnt Signaling via Notch in Intestinal Carcinogenesis by Kaemmerer, Elke, Jeon, Min Kyung, Berndt, Alexander, Liedtke, Christian, Gassler, Nikolaus

“…Proliferation and differentiation of intestinal epithelial cells is assisted by highly specialized and well-regulated signaling cascades. The Wnt pathway,…”
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Cyclotheonellazoles D‑I, Potent Elastase Inhibitory Thiazole-Containing Cyclic Peptides from Theonella sp. (2131) by Holland, Darren C., Schroder, Wayne A., Calcott, Mark J., Kaemmerer, Elke, Avery, Vicky M., Ekins, Merrick G.

“…Six new thiazole-containing cyclic peptides, the cyclotheonellazoles D–I (1–6), were isolated from the Australian marine sponge Theonella sp. (2131) with their…”
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Single molecule microscopy in 3D cell cultures and tissues by Lauer, Florian M., Kaemmerer, Elke, Meckel, Tobias

“…From the onset of the first microscopic visualization of single fluorescent molecules in living cells at the beginning of this century, to the present, almost…”
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Intestinal acyl-CoA synthetase 5: activation of long chain fatty acids and behind by Klaus, Christina, Jeon, Min Kyung, Kaemmerer, Elke, Gassler, Nikolaus

“…The intestinal mucosa is characterized by a high complexity in terms of structure and functions and allows for a controlled demarcation towards the gut lumen…”
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