Comparative Untargeted Metabolomics Analysis of the Psychostimulants 3,4-Methylenedioxy-Methamphetamine (MDMA), Amphetamine, and the Novel Psychoactive Substance Mephedrone after Controlled Drug Administration to Humans

Comparative Untargeted Metabolomics Analysis of the Psychostimulants 3,4-Methylenedioxy-Methamphetamine (MDMA), Amphetamine, and the Novel Psychoactive Substance Mephedrone after Controlled Drug Administration to Humans

Psychoactive stimulants are a popular drug class which are used recreationally. Over the last decade, large numbers of new psychoactive substances (NPS) have entered the drug market and these pose a worldwide problem to human health. Metabolomics approaches are useful tools for simultaneous detectio...

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Bibliographic Details
Published in:Metabolites Vol. 10; no. 8; p. 306
Main Authors: Steuer, Andrea E., Kaelin, Daria, Boxler, Martina I., Eisenbeiss, Lisa, Holze, Friederike, Vizeli, Patrick, Czerwinska, Joanna, Dargan, Paul I., Abbate, Vincenzo, Liechti, Matthias E., Kraemer, Thomas
Format: Journal Article
Language:English
Published: Basel MDPI AG 27-07-2020
MDPI
Subjects:
Amino acids
amphetamine
Amphetamines
Biomarkers
Drug abuse
Drug dosages
Ecstasy
Energy metabolism
Fatty acids
LC-HRMS
Linoleic acid
Liquid chromatography
Mass spectroscopy
MDMA
mephedrone
Metabolism
Metabolites
Metabolomics
Methamphetamine
Plasma
Pregnenolone
psychoactive stimulants
Risk assessment
Statistical analysis
Stimulants
Studies
Sulfates
untargeted metabolomics
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Summary:Psychoactive stimulants are a popular drug class which are used recreationally. Over the last decade, large numbers of new psychoactive substances (NPS) have entered the drug market and these pose a worldwide problem to human health. Metabolomics approaches are useful tools for simultaneous detection of endogenous metabolites affected by drug use. They allow identification of pathways or characteristic metabolites, which might support the understanding of pharmacological actions or act as indirect biomarkers of consumption behavior or analytical detectability. Herein, we performed a comparative metabolic profiling of three psychoactive stimulant drugs 3,4-methylenedioxymethamphetamine (MDMA), amphetamine and the NPS mephedrone by liquid chromatography-high resolution mass spectrometry (LC-HRMS) in order to identify common pathways or compounds. Plasma samples were obtained from controlled administration studies to humans. Various metabolites were identified as increased or decreased based on drug intake, mainly belonging to energy metabolism, steroid biosynthesis and amino acids. Linoleic acid and pregnenolone-sulfate changed similarly in response to intake of all drugs. Overall, mephedrone produced a profile more similar to that of amphetamine than MDMA in terms of affected energy metabolism. These data can provide the basis for further in-depth targeted metabolome studies on pharmacological actions and search for biomarkers of drug use.
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ISSN:2218-1989
2218-1989
DOI:10.3390/metabo10080306