Search Results - "Kaehler, Stefan T"

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    Hyperforin enhances the extracellular concentrations of catecholamines, serotonin and glutamate in the rat locus coeruleus by Kaehler, Stefan T, Sinner, Catrin, Chatterjee, Shyam Sunder, Philippu, Athineos

    Published in Neuroscience letters (12-03-1999)
    “…Hyperforin is the main antidepressant component of hypericum perforatum (St. John's Wort). Using the push-pull superfusion technique we tested whether…”
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    Global Implications of the EU’s Pharmacovigilance System Master File Requirements: Newly Developed Decision Trees to Distinguish Different Study Types by Kaehler, Stefan T., Minton, Neil, Walsh, Nancy, Gillen, David, Bwire, Robert, Freeman, John

    Published in Pharmaceutical medicine (01-12-2015)
    “…In Europe, a new guideline on good pharmacovigilance practices–Module II: Pharmacovigilance system master file (PSMF)—was issued, and initially came into…”
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    Sinoaortic denervation abolishes blood pressure-induced GABA release in the locus coeruleus of conscious rats by Kouvelas, Dimitrios, Singewald, Nicolas, Kaehler, Stefan T., Philippu, Athineos

    Published in Neuroscience letters (30-01-2006)
    “…Male Sprague–Dawley rats underwent sinoaortic denervation (SAD) or sham operation. We examined changes in the release rates of GABA, glutamate and arginine in…”
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    A bioequivalence study of two oral desmopressin tablet formulations by Kaehler, Stefan T, Steiner, Ilka M, Sauermann, Robert, Scheidl, Helmut, Mueller, Markus, Joukhadar, Christian

    Published in Pharmacology (01-01-2006)
    “…The present study was carried out to test bioequivalence between two different oral desmopressin formulations. Sixty healthy volunteers were enrolled in the…”
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    Dependence of serotonin release in the locus coeruleus on dorsal raphe neuronal activity by Kaehler, S T, Singewald, N, Philippu, A

    “…The serotonergic innervation of the locus coeruleus paetly derives from the dorsal raphe nucleus (DRN). Using the push-pull superfusion technique, we…”
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    Noradrenaline release in the locus coeruleus of conscious rats is triggered by drugs, stress and blood pressure changes by Singewald, Nicolas, Kaehler, Stefan T, Philippu, Athineos

    Published in Neuroreport (14-05-1999)
    “…THE in vivo release of noradrenaline (NA) in the locus coeruleus (LC) of conscious rats was enhanced by local superfusion of pargyline, idazoxan, bicuculline,…”
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    A replicate study design for testing bioequivalence: a case study on two desmopressin nasal spray preparations by JOUKHADAR, Christian, SCHENK, Barbara, KAEHLER, Stefan T, KOLLENZ, Christian J, BAUER, Peter, MÜLLER, Markus, EICHLER, Hans-Georg

    Published in European journal of clinical pharmacology (01-11-2003)
    “…The present study was carried out to test bioequivalence between two different desmopressin nasal spray preparations. Due to the high variability of plasma…”
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    Influence of excitatory amino acids on basal and sensory stimuli‐induced release of 5‐HT in the locus coeruleus by Singewald, Nicolas, Kaehler, Stefan T., Hemeida, Ramadan, Philippu, Athineos

    Published in British journal of pharmacology (01-02-1998)
    “…The interactions between 5‐hydroxytryptaminergic neurones and excitatory amino acid utilizing neurones were studied in the locus coeruleus of conscious, freely…”
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    Peripheral chemoreceptor activation enhances 5-hydroxytryptamine release in the locus coeruleus of conscious rats by Singewald, Nicolas, Kouvelas, Dimitrios, Kaehler, Stefan T, Sinner, Catrin, Philippu, Athineos

    Published in Neuroscience letters (28-07-2000)
    “…Intravenous bolus injection of KCN (40 μg) elicited brief but pronounced tachypnea, bradycardia and pressor response, and led to a 37% increase in…”
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    Nitric oxide modulates the release of serotonin in the rat hypothalamus by Kaehler, Stefan T., Singewald, Nicolas, Sinner, Catrin, Philippu, Athineos

    Published in Brain research (24-07-1999)
    “…To investigate the effect of nitric oxide (NO) on the release of serotonin and its main metabolite, 5-hydroxyindoleacetic acid (5-HIAA), the posterior…”
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    Differences between GABA levels in Alzheimer's disease and Down syndrome with Alzheimer-like neuropathology by Seidl, R, Cairns, N, Singewald, N, Kaehler, S T, Lubec, G

    “…Down syndrome (DS) is a genetic disease with developmental brain abnormalities resulting in early mental retardation and precocious, age-dependent…”
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    Therapeutic value of a Lactobacillus gasseri and Bifidobacterium longum fixed bacterium combination in acute diarrhea: a randomized, double-blind, controlled clinical trial by Margreiter, M, Ludl, K, Phleps, W, Kaehler, S T

    “…A multicenter, parallel-group, randomized, double-blind, active-controlled clinical trial, involving 169 outpatients at 9 centers, was conducted to assess the…”
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    Conditioned fear and inescapable shock modify the release of serotonin in the locus coeruleus by Kaehler, Stefan T., Singewald, Nicolas, Sinner, Catrin, Thurnher, Cosima, Philippu, Athineos

    Published in Brain research (24-03-2000)
    “…The aim of the present study was to investigate the importance of the serotonergic transmission in the locus coeruleus (LC) to conditioned fear. Rats were…”
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    Release of catecholamines in the locus coeruleus of freely moving and anaesthetized normotensive and spontaneously hypertensive rats: effects of cardiovascular changes and tail pinch by Kaehler, S T, Sinner, C, Philippu, A

    “…Noradrenaline turnover has been found to be increased in the locus coeruleus of young spontaneously hypertensive rats (SHR). There is also evidence that the…”
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    Release of serotonin in the locus coeruleus of normotensive and spontaneously hypertensive rats (SHR) by Kaehler, S T, Singewald, N, Philippu, A

    “…The aim of the present work was to clarify whether differences exist between the release of endogenous serotonin in the locus coeruleus of normotensive and…”
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    The release of catecholamines in hypothalamus and locus coeruleus is modulated by peripheral chemoreceptors by Kaehler, S T, Singewald, N, Philippu, A

    “…To investigate whether impulses from chemoreceptors influence the release of catecholamines in the hypothalamus and the locus coeruleus, the two brain areas…”
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    Effects of inescapable shock and conditioned fear on the release of excitatory and inhibitory amino acids in the locus coeruleus by Kaehler, S T, Sinner, C, Kouvelas, D, Philippu, A

    “…We investigated the importance of endogenous amino acids in the locus coeruleus in inescapable electric shock and conditioned fear. In naive rats and in rats…”
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