Search Results - "Kaefferlein, Heiko U."

Analyses in human urothelial cells identify methylation of miR-152, miR-200b and miR-10a genes as candidate bladder cancer biomarkers by Köhler, Christina U., Bryk, Oleksandr, Meier, Swetlana, Lang, Kerstin, Rozynek, Peter, Brüning, Thomas, Käfferlein, Heiko U.

“…•We investigate the relationship of DNA methylation and miRNA expression.•Three bladder cancer cell lines are compared to primary urothelial cells.•Expression…”
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Letter to the editor: Negative feasibility for 1-bromopropane and call for additional data by Lowry, Larry K., Hopf, Nancy B., Bader, Michael, Blum, Lee M., Grassman, Jean, Jones, Kate, Kaefferlein, Heiko U., Nylander-French, Leena A., Spies, Gary J., Talaska, Glenn, Viau, Claude

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Partition of metals in the maternal/fetal unit and lead-associated decreases of fetal iron and manganese: an observational biomonitoring approach by Kopp, Ricarda S., Kumbartski, Michael, Harth, Volker, Brüning, Thomas, Käfferlein, Heiko U.

“…To systematically study the partition of environmental metals including lead, mercury, and cadmium and essential minerals such as iron, manganese, copper, and…”
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Expression of PIWIL3 in primary and metastatic melanoma by Gambichler, Thilo, Kohsik, Christina, Höh, Ann-Kathrin, Lang, Kerstin, Käfferlein, Heiko U., Brüning, Thomas, Stockfleth, Eggert, Stücker, Markus, Dreißigacker, Max, Sand, Michael

“…Purpose The PIWI-interacting RNA machinery in malignant melanoma (MM) has not been sufficiently studied. We aimed to investigate the PIWIL3 expression profiles…”
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Oxidatively damaged guanosine in white blood cells and in urine of welders: associations with exposure to welding fumes and body iron stores by Pesch, Beate, Lotz, Anne, Koch, Holger M., Marczynski, Boleslaw, Casjens, Swaantje, Käfferlein, Heiko U., Welge, Peter, Lehnert, Martin, Heinze, Evelyn, Van Gelder, Rainer, Hahn, Jens-Uwe, Behrens, Thomas, Raulf, Monika, Hartwig, Andrea, Weiss, Tobias, Brüning, Thomas

“…The International Agency for Research on Cancer considers the carcinogenicity of welding fume of priority for re-evaluation. Genotoxic effects in experimental…”
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Biomonitoring of volatile organic compounds and organophosphorus flame retardands in commercial aircrews after „fume and smell events by Weiss, Tobias, Koslitz, Stephan, Nöllenheidt, Christoph, Caumanns, Christoph, Hedtmann, Jörg, Käfferlein, Heiko U., Brüning, Thomas

“…Health risks to humans after „fume and smell events“, short-term incidents on aircrafts that are accompanied by unpleasant odour or visible smoke, remain a…”
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Rapid quantification of seven major neonicotinoids and neonicotinoid-like compounds and their key metabolites in human urine by Wrobel, Sonja A., Bury, Daniel, Belov, Vladimir N., Klenk, Jan M., Hauer, Bernhard, Hayen, Heiko, Martino-Andrade, Anderson J., Koch, Holger M., Brüning, Thomas, Käfferlein, Heiko U.

“…Neonicotinoids and neonicotinoid-like compounds (NNIs) are frequently used insecticides worldwide and exposure scenarios can vary widely between countries and…”
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Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages by Wrobel, Sonja A., Bury, Daniel, Hayen, Heiko, Koch, Holger M., Brüning, Thomas, Käfferlein, Heiko U.

“…Few human data on exposure and toxicity are available on neonicotinoids and neonicotinoid-like compounds (NNIs), an important group of insecticides worldwide…”
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Exposure to polycyclic aromatic hydrocarbons assessed by biomonitoring of firefighters during fire operations in Germany by Taeger, Dirk, Koslitz, Stephan, Käfferlein, Heiko U., Pelzl, Tim, Heinrich, Birgit, Breuer, Dietmar, Weiss, Tobias, Harth, Volker, Behrens, Thomas, Brüning, Thomas

“…Firefighters are exposed to a variety of hazardous substances including carcinogens such as polycyclic aromatic hydrocarbons (PAH) during firefighting. In…”
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Noninvasive Diagnosis of High-Grade Urothelial Carcinoma in Urine by Raman Spectral Imaging by Yosef, Hesham K, Krauß, Sascha D, Lechtonen, Tatjana, Jütte, Hendrik, Tannapfel, Andrea, Käfferlein, Heiko U, Brüning, Thomas, Roghmann, Florian, Noldus, Joachim, Mosig, Axel, El-Mashtoly, Samir F, Gerwert, Klaus

“…The current gold standard for the diagnosis of bladder cancer is cystoscopy, which is invasive and painful for patients. Therefore, noninvasive urine cytology…”
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Expression of Programmed Cell Death Proteins in Kaposi Sarcoma and Cutaneous Angiosarcoma by Gambichler, Thilo, Koim, Sonja, Wrobel, Malwina, Käfferlein, Heiko U., Brüning, Thomas, Stockfleth, Eggert, Becker, Jürgen C., Lang, Kerstin

“…Not only for cutaneous angiosarcoma (CAS) patients but also for advanced and therapy-refractory patients with classic Kaposi sarcoma (CKS) and human…”
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LIPG‐promoted lipid storage mediates adaptation to oxidative stress in breast cancer by Cadenas, Cristina, Vosbeck, Sonja, Edlund, Karolina, Grgas, Katharina, Madjar, Katrin, Hellwig, Birte, Adawy, Alshaimaa, Glotzbach, Annika, Stewart, Joanna D., Lesjak, Michaela S., Franckenstein, Dennis, Claus, Maren, Hayen, Heiko, Schriewer, Alexander, Gianmoena, Kathrin, Thaler, Sonja, Schmidt, Marcus, Micke, Patrick, Pontén, Fredrik, Mardinoglu, Adil, Zhang, Cheng, Käfferlein, Heiko U., Watzl, Carsten, Frank, Saša, Rahnenführer, Jörg, Marchan, Rosemarie, Hengstler, Jan G.

“…Endothelial lipase (LIPG) is a cell surface associated lipase that displays phospholipase A1 activity towards phosphatidylcholine present in high‐density…”
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Environmentally prevalent polycyclic aromatic hydrocarbons can elicit co-carcinogenic properties in an in vitro murine lung epithelial cell model by Bauer, Alison K., Velmurugan, Kalpana, Plöttner, Sabine, Siegrist, Katelyn J., Romo, Deedee, Welge, Peter, Brüning, Thomas, Xiong, Ka-Na, Käfferlein, Heiko U.

“…Low molecular weight (LMW) polycyclic aromatic hydrocarbons (PAH) are the most abundant PAHs environmentally, occupationally, and are in cigarette smoke;…”
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Use of Multiple Machine Learning Approaches for Selecting Urothelial Cancer-Specific DNA Methylation Biomarkers in Urine by Köhler, Christina U, Schork, Karin, Turewicz, Michael, Eisenacher, Martin, Roghmann, Florian, Noldus, Joachim, Marcus, Katrin, Brüning, Thomas, Käfferlein, Heiko U

“…Diagnosing urothelial cancer (UCa) via invasive cystoscopy is painful, specifically in men, and can cause infection and bleeding. Because the UCa risk is…”
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Toward noninvasive follow-up of low-risk bladder cancer – Rationale and concept of the UroFollow trial by Benderska-Söder, Natalya, Hovanec, Jan, Pesch, Beate, Goebell, Peter J., Roghmann, Florian, Noldus, Joachim, Rabinovich, Juri, Wichert, Katharina, Gleichenhagen, Jan, Käfferlein, Heiko U., Köhler, Christina U., Johnen, Georg, Kernig, Karoline, Hakenberg, Oliver, Jahn, Daniela, Todenhöfer, Tilman, Stenzl, Arnulf, Gleissner, Jochen, Gerwert, Klaus, El-Mashtoly, Samir, Behrens, Thomas, Brüning, Thomas, Schmitz-Dräger, Bernd J.

“…•Randomized trials regarding the use of markers for follow-up of patients with pTa G1/G2 bladder cancer are missing.•Current recommendations might be prone to…”
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Impact of diesel exhaust exposure on urinary 1-hydroxypyrene in underground salt and potash workers by Casjens, Swaantje, Neumann, Savo, Rühle, Katrin, Gamrad-Streubel, Lisa, Haase, Lisa-Marie, Rudolph, Katharina K., Birk, Thomas, Giesen, Jörg, Neumann, Volker, Pallapies, Dirk, Bünger, Jürgen, Käfferlein, Heiko U., Behrens, Thomas, Brüning, Thomas, Taeger, Dirk

“…Background. Diesel engine exhaust (DEE) and some of the polycyclic aromatic hydrocarbons (PAH) it contains are carcinogenic to humans (for example…”
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Noninvasive diagnosis of urothelial cancer in urine using DNA hypermethylation signatures—Gender matters by Köhler, Christina U., Bonberg, Nadine, Ahrens, Maike, Behrens, Thomas, Hovanec, Jan, Eisenacher, Martin, Noldus, Joachim, Deix, Thomas, Braun, Katharina, Gohlke, Henning, Walter, Michael, Tannapfel, Andrea, Tam, Yu, Sommerer, Florian, Marcus, Katrin, Jöckel, Karl‐Heinz, Erbel, Raimund, Cantor, Charles R., Käfferlein, Heiko U., Brüning, Thomas

“…Urothelial cancer (UCa) is the most predominant cancer of the urinary tract and noninvasive diagnosis using hypermethylation signatures in urinary cells is…”
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TGFBI Protein Is Increased in the Urine of Patients with High-Grade Urothelial Carcinomas, and Promotes Cell Proliferation and Migration by Lang, Kerstin, Kahveci, Selcan, Bonberg, Nadine, Wichert, Katharina, Behrens, Thomas, Hovanec, Jan, Roghmann, Florian, Noldus, Joachim, Tam, Yu Chun, Tannapfel, Andrea, Käfferlein, Heiko U, Brüning, Thomas

“…Here, we discovered TGFBI as a new urinary biomarker for muscle invasive and high-grade urothelial carcinoma (UC). After biomarker identification using…”
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Toxicokinetics of N-ethyl-2-pyrrolidone and its metabolites in blood, urine and amniotic fluid of rats after oral administration by Bury, Daniel, Saillenfait, Anne Marie, Marquet, Fabrice, Käfferlein, Heiko U., Brüning, Thomas, Koch, Holger M.

“…The toxicokinetics of N -ethyl-2-pyrrolidone (NEP), an embryotoxic organic solvent, has been studied in Sprague–Dawley rats after oral exposure. NEP and its…”
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Levels and predictors of airborne and internal exposure to chromium and nickel among welders—Results of the WELDOX study by Weiss, Tobias, Pesch, Beate, Lotz, Anne, Gutwinski, Eleonore, Van Gelder, Rainer, Punkenburg, Ewald, Kendzia, Benjamin, Gawrych, Katarzyna, Lehnert, Martin, Heinze, Evelyn, Hartwig, Andrea, Käfferlein, Heiko U., Hahn, Jens-Uwe, Brüning, Thomas

“…The objective of this analysis was to investigate levels and determinants of exposure to airborne and urinary chromium (Cr, CrU) and nickel (Ni, NiU) among 241…”
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