Search Results - "Kaech, Susan"

Transcriptional control of effector and memory CD8+ T cell differentiation by Kaech, Susan M., Cui, Weiguo

“…Key Points During an infection, T cells can differentiate into multiple types of effector and memory T cell that help to mediate pathogen clearance and provide…”
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An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8 + T Cells by Cui, Weiguo, Liu, Ying, Weinstein, Jason S., Craft, Joseph, Kaech, Susan M.

“…Memory CD8 + T cells are critical for long-term immunity, but the genetic pathways governing their formation remain poorly defined. This study shows that the…”
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The multifaceted role of CD4+ T cells in CD8+ T cell memory by Laidlaw, Brian J., Craft, Joseph E., Kaech, Susan M.

“…Key Points Following immunization, CD4 + T cells promote the induction of a robust primary CD8 + T cell response through numerous mechanisms, including…”
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Metabolic Instruction of Immunity by Buck, Michael D., Sowell, Ryan T., Kaech, Susan M., Pearce, Erika L.

“…Choices have consequences. Immune cells survey and migrate throughout the body and sometimes take residence in niche environments with distinct communities of…”
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CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection by Laidlaw, Brian J., Zhang, Nianzhi, Marshall, Heather D., Staron, Mathew M., Guan, Tianxia, Hu, Yinghong, Cauley, Linda S., Craft, Joe, Kaech, Susan M.

“…Tissue-resident memory T (Trm) cells provide enhanced protection against infection at mucosal sites. Here we found that CD4+ T cells are important for the…”
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The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection by Staron, Matthew M., Gray, Simon M., Marshall, Heather D., Parish, Ian A., Chen, Jonathan H., Perry, Curtis J., Cui, Guoliang, Li, Ming O., Kaech, Susan M.

“…Protein kinase B (also known as AKT) and the mechanistic target of rapamycin (mTOR) are central regulators of T cell differentiation, proliferation,…”
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The MicroRNA miR-181 Is a Critical Cellular Metabolic Rheostat Essential for NKT Cell Ontogenesis and Lymphocyte Development and Homeostasis by Henao-Mejia, Jorge, Williams, Adam, Goff, Loyal A., Staron, Matthew, Licona-Limón, Paula, Kaech, Susan M., Nakayama, Maki, Rinn, John L., Flavell, Richard A.

“…Regulation of metabolic pathways in the immune system provides a mechanism to actively control cellular function, growth, proliferation, and survival. Here, we…”
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Transcription Factor STAT3 and Type I Interferons Are Corepressive Insulators for Differentiation of Follicular Helper and T Helper 1 Cells by Ray, John P., Marshall, Heather D., Laidlaw, Brian J., Staron, Matthew M., Kaech, Susan M., Craft, Joe

“…Follicular helper T (Tfh) cells are required for the establishment of T-dependent B cell memory and high affinity antibody-secreting cells. We have revealed…”
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Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses by Ho, Ping-Chih, Bihuniak, Jessica Dauz, Macintyre, Andrew N., Staron, Matthew, Liu, Xiaojing, Amezquita, Robert, Tsui, Yao-Chen, Cui, Guoliang, Micevic, Goran, Perales, Jose C., Kleinstein, Steven H., Abel, E. Dale, Insogna, Karl L., Feske, Stefan, Locasale, Jason W., Bosenberg, Marcus W., Rathmell, Jeffrey C., Kaech, Susan M.

“…Activated T cells engage aerobic glycolysis and anabolic metabolism for growth, proliferation, and effector functions. We propose that a glucose-poor tumor…”
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Generation of effector CD8⁺ T cells and their conversion to memory T cells by Cui, Weiguo, Kaech, Susan M

“…Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to elucidate the mechanisms that govern the formation of memory T cells…”
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CD8+ T cells in the cancer-immunity cycle by Giles, Josephine R., Globig, Anna-Maria, Kaech, Susan M., Wherry, E. John

“…CD8+ T cells are end effectors of cancer immunity. Most forms of effective cancer immunotherapy involve CD8+ T cell effector function. Here, we review the…”
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Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes by Perry, Rachel J., Camporez, João-Paulo G., Kursawe, Romy, Titchenell, Paul M., Zhang, Dongyan, Perry, Curtis J., Jurczak, Michael J., Abudukadier, Abulizi, Han, Myoung Sook, Zhang, Xian-Man, Ruan, Hai-Bin, Yang, Xiaoyong, Caprio, Sonia, Kaech, Susan M., Sul, Hei Sook, Birnbaum, Morris J., Davis, Roger J., Cline, Gary W., Petersen, Kitt Falk, Shulman, Gerald I.

“…Impaired insulin-mediated suppression of hepatic glucose production (HGP) plays a major role in the pathogenesis of type 2 diabetes (T2D), yet the molecular…”
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IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity by Cui, Guoliang, Staron, Matthew M., Gray, Simon M., Ho, Ping-Chih, Amezquita, Robert A., Wu, Jingxia, Kaech, Susan M.

“…Memory T cells are critical for long-term immunity against reinfection and require interleukin-7 (IL-7), but the mechanisms by which IL-7 controls memory…”
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KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity by Herndler-Brandstetter, Dietmar, Ishigame, Harumichi, Shinnakasu, Ryo, Plajer, Valerie, Stecher, Carmen, Zhao, Jun, Lietzenmayer, Melanie, Kroehling, Lina, Takumi, Akiko, Kometani, Kohei, Inoue, Takeshi, Kluger, Yuval, Kaech, Susan M., Kurosaki, Tomohiro, Okada, Takaharu, Flavell, Richard A.

“…Protective immunity against pathogens depends on the efficient generation of functionally diverse effector and memory T lymphocytes. However, whether…”
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Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8+ T Cell Terminal Differentiation and Loss of Multipotency by Gray, Simon M., Amezquita, Robert A., Guan, Tianxia, Kleinstein, Steven H., Kaech, Susan M.

“…Understanding immunological memory formation depends on elucidating how multipotent memory precursor (MP) cells maintain developmental plasticity and longevity…”
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Tick-TOX, it’s time for T cell exhaustion by Mann, Thomas H., Kaech, Susan M.

“…The transcription factor TOX epigenetically reprograms CD8 + T cells to drive T cell exhaustion during chronic infection and cancer. Although they are…”
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Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4 + Cell Properties during Viral Infection by Marshall, Heather D., Chandele, Anmol, Jung, Yong Woo, Meng, Hailong, Poholek, Amanda C., Parish, Ian A., Rutishauser, Rachel, Cui, Weiguo, Kleinstein, Steven H., Craft, Joe, Kaech, Susan M.

“…CD4 + T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4…”
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The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells by Ray, John P., Staron, Matthew M., Shyer, Justin A., Ho, Ping-Chih, Marshall, Heather D., Gray, Simon M., Laidlaw, Brian J., Araki, Koichi, Ahmed, Rafi, Kaech, Susan M., Craft, Joe

“…The differentiation of CD4+ helper T cell subsets with diverse effector functions is accompanied by changes in metabolism required to meet their bioenergetic…”
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The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates by Chung, H Kay, McDonald, Bryan, Kaech, Susan M

“…In response to infection, T cells adopt a range of differentiation states, creating numerous heterogeneous subsets that exhibit different phenotypes,…”
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Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence by Harel, Michal, Ortenberg, Rona, Varanasi, Siva Karthik, Mangalhara, Kailash Chandra, Mardamshina, Mariya, Markovits, Ettai, Baruch, Erez N., Tripple, Victoria, Arama-Chayoth, May, Greenberg, Eyal, Shenoy, Anjana, Ayasun, Ruveyda, Knafo, Naama, Xu, Shihao, Anafi, Liat, Yanovich-Arad, Gali, Barnabas, Georgina D., Ashkenazi, Shira, Besser, Michal J., Schachter, Jacob, Bosenberg, Marcus, Shadel, Gerald S., Barshack, Iris, Kaech, Susan M., Markel, Gal, Geiger, Tamar

“…Immunotherapy has revolutionized cancer treatment, yet most patients do not respond. Here, we investigated mechanisms of response by profiling the proteome of…”
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