Search Results - "Kadwell, Sue H"

Discovery of Novel Quinoline-Based Estrogen Receptor Ligands Using Peptide Interaction Profiling by Hoekstra, William J, Patel, Hari S, Liang, Xi, Blanc, Jean-Baptiste E, Heyer, Dennis O, Willson, Timothy M, Iannone, Marie A, Kadwell, Sue H, Miller, Lisa A, Pearce, Kenneth H, Simmons, Catherine A, Shearin, Jean

“…Traditional approaches to discovery of selective estrogen receptor modulators (SERMs) have relied on ER binding and cell-based estrogen response element-driven…”
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Protein Expression in Insect and Mammalian Cells Using Baculoviruses in Wave Bioreactors by Kadwell, Sue H, Overton, Laurie K

“…Many types of disposable bioreactors for protein expression in insect and mammalian cells are now available. They differ in design, capacity, and sensor…”
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The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: Potential therapy for cancer by RUSNAK, David W, AFFLECK, Karen, JOWETT, Amanda, STABLES, Jeremy, TOPLEY, Peter, WOOD, Edgar R, BRIGNOLA, Perry S, KADWELL, Sue H, REEP, Bryan R, MULLIN, Robert J, ALLIGOOD, Krystal J, KEITH, Barry R, COCKERILL, Stuart G, CROSBY, Renae M, MURRAY, Doris M, KNIGHT, W. Blaine, GILMER, Tona M, LACKEY, Karen, STUBBERFIELD, Colin, HARRIS, Robert, PAGE, Martin, SMITH, Kathryn J, GUNTRIP, Stephen B, CARTER, Malcolm C, SHAW, Robert J

“…The type I receptor tyrosine kinases constitute a family of transmembrane proteins involved in various aspects of cell growth and survival and have been…”
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Production of baculovirus-expressed recombinant proteins in wave bioreactors by Kadwell, Sue H, Hardwicke, Philip I

“…Wave Bioreactors are relatively new to the field of protein production from insect cells infected with recombinant baculoviruses. Various sizes are available…”
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Correlation between in Vitro Peptide Binding Profiles and Cellular Activities for Estrogen Receptor-Modulating Compounds by Iannone, Marie A, Simmons, Catherine A, Kadwell, Sue H, Svoboda, Daniel L, Vanderwall, Dana E, Deng, Su-Jun, Consler, Thomas G, Shearin, Jean, Gray, John G, Pearce, Kenneth H

“…Numerous biochemical and structural studies have shown that the conformation of the estrogen receptor α (ERα) can be influenced by ligand binding. In turn, the…”
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Structure of the Tie2 RTK Domain: Self-Inhibition by the Nucleotide Binding Loop, Activation Loop, and C-Terminal Tail by Shewchuk, Lisa M, Hassell, Anne M, Ellis, Byron, Holmes, W.D, Davis, Roderick, Horne, Earnest L, Kadwell, Sue H, McKee, David D, Moore, John T

“…Background: Angiogenesis, the formation of new vessels from the existing vasculature, is a critical process during early development as well as in a number of…”
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Comparison of the biochemical and kinetic properties of the type 1 receptor tyrosine kinase intracellular domains. Demonstration of differential sensitivity to kinase inhibitors by Brignola, Perry S, Lackey, Karen, Kadwell, Sue H, Hoffman, Christine, Horne, Earnest, Carter, H Luke, Stuart, J Darren, Blackburn, Kevin, Moyer, Mary B, Alligood, Krystal J, Knight, Wilson B, Wood, Edgar R

“…Epidermal growth factor receptor (EGFR), ErbB-2, and ErbB-4 are members of the type 1 receptor tyrosine kinase family. Overexpression of these receptors,…”
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Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases : determinants for different in vivo activities of GI198745 and finasteride in the rat by STUART, J. Darren, LEE, Frank W, BRAMSON, H. Neal, NOEL, Deborah Simpson, KADWELL, Sue H, OVERTON, Laurie K, HOFFMAN, Christine R, KOST, Thomas A, TIPPIN, Timothy K, YEAGER, Russell L, BATCHELOR, Kenneth W

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Human Recombinant Phosphodiesterase 4B2B Binds (R)-Rolipram at a Single Site with Two Affinities by Rocque, Warren J, Tian, Gaochao, Wiseman, Jeffrey S, Holmes, William D, Zajac-Thompson, Irene, Willard, Derril H, Patel, Indravaden R, Wisely, G. Bruce, Clay, William C, Kadwell, Sue H, Hoffman, Christine R, Luther, Michael A

“…The interactions between (R)-rolipram and purified human recombinant low-K m, cAMP-specific phosphodiesterase (HSPDE4B2B) constructs were investigated using…”
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Comparison of the Biochemical and Kinetic Properties of the Type 1 Receptor Tyrosine Kinase Intracellular Domains by Brignola, Perry S., Lackey, Karen, Kadwell, Sue H., Hoffman, Christine, Horne, Earnest, Carter, H. Luke, Stuart, J. Darren, Blackburn, Kevin, Moyer, Mary B., Alligood, Krystal J., Knight, Wilson B., Wood, Edgar R.

“…Epidermal growth factor receptor (EGFR), ErbB-2, and ErbB-4 are members of the type 1 receptor tyrosine kinase family. Overexpression of these receptors,…”
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Inhibition of Human Steroid 5α Reductases type I and II by 6-Aza-Steroids:  Structural Determinants of One-Step vs Two-Step Mechanism by Moss, Marcia L, Kuzmič, Petr, Stuart, J. Darren, Tian, Gaochao, Peranteau, Anne G, Frye, Stephen V, Kadwell, Sue H, Kost, Thomas A, Overton, Laurie K, Patel, Indravadan R

“…We have discovered that 17β-[N,N-(diethyl)carbamoyl]-6-azaandrost-4-en-3-one is a time-dependent inhibitor of type II 5α-reductase, as is the drug finasteride…”
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Production and characterization of an estrogen receptor beta subtype-specific mouse monoclonal antibody by Su, J L, McKee, D D, Ellis, B, Kadwell, S H, Wisely, G B, Moore, L B, Triantafillou, J A, Kost, T A, Fuqua, S, Moore, J T

“…An important step in differentiating the unique physiological roles of the alpha and beta forms of estrogen receptor is to determine the precise expression…”
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17.beta.-(N-tert-Butylcarbamoyl)-4-aza-5.alpha.-androstan-1-en-3-one Is an Active Site-Directed Slow Time-Dependent Inhibitor of Human Steroid 5.alpha.-Reductase 1 by Tian, Gaochao, Stuart, J. Darren, Moss, Marcia L, Domanico, Paul L, Bramson, H. Neal, Patel, Indravadan R, Kadwell, Sue H, Overton, Laurie K, Kost, Thomas A

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Agouti regulation of intracellular calcium: role in the insulin resistance of viable yellow mice by Zemel, M.B. (University of Tennessee, Knoxville, TN.), Kim, J.H, Woychik, R.P, Michaud, E.J, Kadwell, S.H, Patel, I.R, Wilkison, W.O

“…Several dominant mutations at the agouti locus in the mouse cause a syndrome of marked obesity, hyperinsulinemia, and insulin resistance. Although it is known…”
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CYP3A4 Expressed by Insect Cells Infected with a Recombinant Baculovirus Containing Both CYP3A4 and Human NADPH-Cytochrome P450 Reductase Is Catalytically Similar to Human Liver Microsomal CYP3A4 by Lee, C.A., Kadwell, S.H., Kost, T.A., Serabjitsingh, C.J.

“…Human cytochrome CYP3A4 is the most abundant of all the P450s in human liver and is involved in the metabolism of many environmental toxicants and drugs…”
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Structure of the Tie2 RTK Domain by Shewchuk, Lisa M, Hassell, Anne M, Ellis, Byron, Holmes, W.D, Davis, Roderick, Horne, Earnest L, Kadwell, Sue H, McKee, David D, Moore, John T

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Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone by Darren Stuart, J., Lee, Frank W., Simpson Noel, Deborah, Kadwell, Sue H., Overton, Laurie K., Hoffman, Christine R., Kost, Thomas A., Tippin, Timothy K., Yeager, Russell L., Batchelor, Kenneth W., Neal Bramson, H.

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Cyclic AMP signaling pathways are important in IL-1 beta transcriptional regulation by Chandra, G, Cogswell, JP, Miller, LR, Godlevski, MM, Stinnett, SW, Noel, SL, Kadwell, SH, Kost, TA, Gray, JG

“…An intact cAMP response element (CRE) in the upstream regulatory sequence of IL-1 beta (-2755/-2762) has been shown to be essential for maintaining full IL-1…”
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17β-(N-tert-butylcarbamoyl)-4-aza-5α-androstan-1-en-3-one is an active site-directed slow time-dependent inhibitor of human steroid 5α-reductase 1 by GAOCHAO TIAN, STUART, J. D, FRYE, S. V, BATCHELOR, K. W, WISEMAN, J. S, MOSS, M. L, DOMANICO, P. L, BRAMSON, H. N, PATEL, I. R, KADWELL, S. H, OVERTON, L. K, KOST, T. A, MOOK, R. A

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Characterization of human E4BP4, a phosphorylated bZIP factor by Chen, Wen-Ji, Lewis, Kelly S., Chandra, Gyan, Cogswell, John P., Stinnett, Sandra W., Kadwell, Sue H., Gray, John G.

“…In this report we described the isolation of the transcription factor E4BP4 by λgt11 expression cloning using a probe containing the CRE/ATF-like sequence…”
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