Search Results - "Kadurin, Ivan"

Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary α₂δ-1 subunits by Cassidy, John S., Ferron, Laurent, Kadurin, Ivan, Pratt, Wendy S., Dolphin, Annette C.

“…Ca V1 and Ca V2 voltage-gated calcium channels are associated with β and α ₂δ accessory subunits. However, examination of cell surface-associated Ca V2…”
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Proteolytic maturation of α2δ controls the probability of synaptic vesicular release by Ferron, Laurent, Kadurin, Ivan, Dolphin, Annette C

“…Auxiliary α2δ subunits are important proteins for trafficking of voltage-gated calcium channels (CaV) at the active zones of synapses. We have previously shown…”
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α₂δ subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function by Davies, Anthony, Kadurin, Ivan, Alvarez-Laviada, Anita, Douglas, Leon, Nieto-Rostro, Manuela, Bauer, Claudia S, Pratt, Wendy S, Dolphin, Annette C

“…Voltage-gated calcium channels are thought to exist in the plasma membrane as heteromeric proteins, in which the α1 subunit is associated with two auxiliary…”
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Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses by Huang, Zhuo, Lujan, Rafael, Kadurin, Ivan, Uebele, Victor N, Renger, John J, Dolphin, Annette C, Shah, Mala M

“…The authors find that hyperpolarization-activated cyclic nucleotide–gated 1 (HCN1) channel subunits are localized to the active zone of asymmetric synaptic…”
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The α2δ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with α2δ-1 by Dahimene, Shehrazade, Page, Karen M., Kadurin, Ivan, Ferron, Laurent, Ho, Dominique Y., Powell, Gareth T., Pratt, Wendy S., Wilson, Stephen W., Dolphin, Annette C.

“…Voltage-gated calcium channel auxiliary α2δ subunits are important for channel trafficking and function. Here, we compare the effects of α2δ-1 and an α2δ-like…”
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Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels by Kadurin, Ivan, Ferron, Laurent, Rothwell, Simon W, Meyer, James O, Douglas, Leon R, Bauer, Claudia S, Lana, Beatrice, Margas, Wojciech, Alexopoulos, Orpheas, Nieto-Rostro, Manuela, Pratt, Wendy S, Dolphin, Annette C

“…The auxiliary α2δ subunits of voltage-gated calcium channels are extracellular membrane-associated proteins, which are post-translationally cleaved into…”
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Disruption of the Key Ca2+ Binding Site in the Selectivity Filter of Neuronal Voltage-Gated Calcium Channels Inhibits Channel Trafficking by Meyer, James O., Dahimene, Shehrazade, Page, Karen M., Ferron, Laurent, Kadurin, Ivan, Ellaway, Joseph I.J., Zhao, Pengxiang, Patel, Tarun, Rothwell, Simon W., Lin, Peipeng, Pratt, Wendy S., Dolphin, Annette C.

“…Voltage-gated calcium channels are exquisitely Ca2+ selective, conferred primarily by four conserved pore-loop glutamate residues contributing to the…”
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A single conserved proline residue determines the membrane topology of stomatin by Kadurin, Ivan, Huber, Stephan, Gründer, Stefan

“…Stomatin is an integral membrane protein which is widely expressed in many cell types. It is accepted that stomatin has a unique hairpin-loop topology: it is…”
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Zebrafish Acid-sensing Ion Channel (ASIC) 4, Characterization of Homo- and Heteromeric Channels, and Identification of Regions Important for Activation by H by Chen, Xuanmao, Polleichtner, Georg, Kadurin, Ivan, Gründer, Stefan

“…There are four genes for acid-sensing ion channels (ASICs) in the genome of mammalian species. Whereas ASIC1 to ASIC3 form functional H+-gated Na+ channels,…”
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Differential effects of N-glycans on surface expression suggest structural differences between the acid-sensing ion channel (ASIC) 1a and ASIC1b by Kadurin, Ivan, Golubovic, Andjelko, Leisle, Lilia, Schindelin, Hermann, Gründer, Stefan

“…ASICs (acid-sensing ion channels) are H(+)-gated Na(+) channels with a widespread expression pattern in the central and the peripheral nervous system. ASICs…”
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The Increased Trafficking of the Calcium Channel Subunit α2δ-1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the α2δ Ligand Pregabalin by Bauer, Claudia S., Nieto-Rostro, Manuela, Rahman, Wahida, Tran-Van-Minh, Alexandra, Ferron, Laurent, Douglas, Leon, Kadurin, Ivan, Sri Ranjan, Yorain, Fernandez-Alacid, Laura, Millar, Neil S., Dickenson, Anthony H., Lujan, Rafael, Dolphin, Annette C.

“…Neuropathic pain results from damage to the peripheral sensory nervous system, which may have a number of causes. The calcium channel subunit α 2 δ-1 is…”
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Proteolytic maturation of α 2 δ controls the probability of synaptic vesicular release by Ferron, Laurent, Kadurin, Ivan, Dolphin, Annette C

“…Auxiliary α δ subunits are important proteins for trafficking of voltage-gated calcium channels (Ca ) at the active zones of synapses. We have previously shown…”
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Fight or flight: The culprit is lurking in the neighbourhood by Dolphin, Annette C, Kadurin, Ivan

“…The fight-or-flight response is studied by all students of Physiology as a concerted bodily response to danger. Liu et al (2020) have now revealed its…”
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Proteolytic maturation of [alpha].sub.2[delta] controls the probability of synaptic vesicular release by Ferron, Laurent, Kadurin, Ivan, Dolphin, Annette C

“…Auxiliary [alpha].sub.2[delta] subunits are important proteins for trafficking of voltage-gated calcium channels (Ca.sub.V) at the active zones of synapses. We…”
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Biallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy by Dahimene, Shehrazade, von Elsner, Leonie, Holling, Tess, Mattas, Lauren S, Pickard, Jess, Lessel, Davor, Pilch, Kjara S, Kadurin, Ivan, Pratt, Wendy S, Zhulin, Igor B, Dai, Hongzheng, Hempel, Maja, Ruzhnikov, Maura R Z, Kutsche, Kerstin, Dolphin, Annette C

“…Voltage-gated calcium (CaV) channels form three subfamilies (CaV1-3). The CaV1 and CaV2 channels are heteromeric, consisting of an α1 pore-forming subunit,…”
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Investigation of the Proteolytic Cleavage of α2δ Subunits: A Mechanistic Switch from Nhibition to Activation of Voltage-Gated Calcium Channels? by Kadurin, Ivan, Rothwell, Simon, Ferron, Laurent, Meyer, Otto, Dolphin, Annette

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Investigation of the Proteolytic Cleavage of α 2 δ Subunits: A Mechanistic Switch from Nhibition to Activation of Voltage-Gated Calcium Channels? by Kadurin, Ivan, Rothwell, Simon, Ferron, Laurent, Meyer, Otto, Dolphin, Annette

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LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α2δ-1 subunit by Kadurin, Ivan, Rothwell, Simon W., Lana, Beatrice, Nieto-Rostro, Manuela, Dolphin, Annette C.

“…Voltage-gated Ca 2+ (Ca V ) channels consist of a pore-forming α1 subunit, which determines the main functional and pharmacological attributes of the channel…”
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A new look at calcium channel α2δ subunits by Bauer, Claudia S, Tran-Van-Minh, Alexandra, Kadurin, Ivan, Dolphin, Annette C

“…The classical roles of α(2)δ proteins are as accessory calcium channel subunits, enhancing channel trafficking. They were thought to have type-I transmembrane…”
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Posttranslational Proteolytic Cleavage of α2δ Subunits: Functional Implications for High Voltage-Gated Calcium Channels by Kadurin, Ivan, Rothwell, Simon, Meyer, Otto, Bauer, Claudia, Douglas, Leon, Dolphin, Annette

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