Search Results - "Kadowitz, P"

Adipose tissue–derived stem cell therapy for prevention and treatment of erectile dysfunction in a rat model of Peyronie's disease by Gokce, A., Abd Elmageed, Z. Y., Lasker, G. F., Bouljihad, M., Kim, H., Trost, L. W., Kadowitz, P. J., Abdel‐Mageed, A. B., Sikka, S. C., Hellstrom, W. J.

“…Summary Peyronie's disease (PD) is a localized connective tissue disorder that involves the tunica albuginea (TA) of the penis. While surgical correction…”
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Characterisation of pomegranate juice effects on human corpus cavernosum by Gur, S., Rezk, B. M., Abd Elmageed, Z. Y., Kadowitz, P. J., Sikka, S. C., Hellstrom, W. J. G.

“…Summary Pomegranate (POM) juice may benefit the erectile process, but the scientific evidence is lacking. This study evaluates the molecular characterisation…”
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Antiproliferative effects of calcitonin gene-related peptide in aortic and pulmonary artery smooth muscle cells by Chattergoon, N N, D'Souza, F M, Deng, W, Chen, H, Hyman, A L, Kadowitz, P J, Jeter, Jr, J R

“…Pulmonary hypertension is characterized by vascular remodeling involving smooth muscle cell proliferation and migration. Calcitonin gene-related peptide (CGRP)…”
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Gene Transfer of Endothelial Nitric Oxide Synthase to the Penis Augments Erectile Responses in the Aged Rat by Champion, H C, Bivalacqua, T J, Hyman, A L, Ignarro, L J, Hellstrom, W J, Kadowitz, P J

“…Nitric oxide (NO), a mediator involved in penile erection, is synthesized by the nitric oxide synthase (NOS) family of enzymes. It has been shown that NOS…”
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Effect of avanafil on rat and human corpus cavernosum by Gur, S., Sikka, S. C., Pankey, E. A., Lasker, G. F., Chandra, S., Kadowitz, P. J., Hellstrom, W. J. G.

“…Summary We compared the activity of a new phosphodiesterase‐5 inhibitor (PDE5i) avanafil with sildenafil and tadalafil in human and rat corpus cavernosum (CC)…”
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RhoA/Rho-Kinase Suppresses Endothelial Nitric Oxide Synthase in the Penis: A Mechanism for Diabetes-Associated Erectile Dysfunction by Bivalacqua, Trinity J., Champion, Hunter C., Usta, Mustafa F., Cellek, Selim, Chitaley, Kanchan, Webb, R. Clinton, Lewis, Ronald L., Mills, Thomas M., Wayne J. G. Hellstrom, Kadowitz, Philip J., Ignarro, Louis J.

“…Significant impairment in endothelial-derived nitric oxide is present in the diabetic corpus cavernosum. RhoA/Rho-kinase may suppress endothelial nitric oxide…”
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Effect of combination endothelial nitric oxide synthase gene therapy and sildenafil on erectile function in diabetic rats by Bivalacqua, T J, Usta, M F, Champion, H C, Leungwattanakij, S, Dabisch, P A, McNamara, D B, Kadowitz, P J, Hellstrom, W J G

“…Erectile dysfunction associated with diabetes mellitus is caused in part by disordered endothelial smooth muscle relaxation, neuropathy, and a decrease in…”
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Adenoviral gene transfer of endothelial nitric oxide synthase (eNOS) to the penis improves age-related erectile dysfunction in the rat by BIVALACQUA, T. J, CHAMPION, H. C, MEHTA, Y. S, ABDEL-MAGEED, A. B, SIKKA, S. C, IGNARRO, L. J, KADOWITZ, P. J, HELLSTROM, W. J. G

“…Nitric oxide (NO) is the principal mediator of penile erection. NO is synthesized by a variety of nitric oxide synthases (NOS). It has been demonstrated that a…”
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Animal models of catheter-induced intimal hyperplasia in type 1 and type 2 diabetes and the effects of pharmacologic intervention by McNamara, D B, Murthy, S N, Fonseca, A N, Desouza, C V, Kadowitz, P J, Fonseca, V A

“…Diabetes is a complex disorder characterized by impaired insulin formation, release or action (insulin resistance), elevated blood glucose, and multiple…”
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Gene and stem cell therapy for erectile dysfunction by DENG, W, BIVALACQUA, T. J, HELLSTROM, W. J. G, KADOWITZ, P. J

“…Erectile dysfunction (ED) is defined as the inability to attain and/or maintain penile erection sufficient for satisfactory sexual performance. ED is a highly…”
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A rat model of Peyronie's disease associated with a decrease in erectile activity and an increase in inducible nitric oxide synthase protein expression by Bivalacqua, T J, Diner, E K, Novak, T E, Vohra, Y, Sikka, S C, Champion, H C, Kadowitz, P J, Hellstrom, W J

“…Our objective was to assess erectile function in saline-injected, transforming growth factor-beta 1 (TGF-beta1)-injected, and surgical injury rats after six…”
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Gene Transfer of Prepro-Calcitonin Gene-Related Peptide Restores Erectile Function in the Aged Rat by BIVALACQUA, Trinity J, CHAMPION, Hunter C, ABDEL-MAGEED, Asim B, KADOWITZ, Philip J, HELLSTROM, Wayne J. G

“…Erectile dysfunction in the aging male is caused, in part, by inadequate relaxation of the corpora cavernosal smooth musculature. Calcitonin gene-related…”
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Renal responses to intra-arterial administration of adrenomedullin in dogs by Majid, D S, Kadowitz, P J, Coy, D H, Navar, L G

“…The present study was undertaken to evaluate the renal responses to intra-arterial infusion (12.5 pmol.kg-1.min-1) for 30 min of adrenomedullin (ADM) in…”
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In vivo gene transfer of prepro-calcitonin gene-related peptide to the lung attenuates chronic hypoxia-induced pulmonary hypertension in the mouse by CHAMPION, H. C, BIVALACQUA, T. J, TOYODA, K, HEISTAD, D. D, HYMAN, A. L, KADOWITZ, P. J

“…Calcitonin gene-related peptide (CGRP) is believed to play an important role in maintaining low pulmonary vascular resistance (PVR) and in modulating pulmonary…”
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Increased Expression of Arginase II in Human Diabetic Corpus Cavernosum: In Diabetic-Associated Erectile Dysfunction by Bivalacqua, Trinity J., Hellstrom, Wayne J.G., Kadowitz, Philip J., Champion, Hunter C.

“…Nitric oxide (NO) is the principal mediator of penile erection. NO is synthesized by nitric oxide synthase (NOS). It has been well documented that the major…”
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Pressor responses to ephedrine are not impaired in dopamine β‐hydroxylase knockout mice by Liles, J T, Baber, S R, Deng, W, Porter, J R, Corll, C, Murthy, S N, Thomas, S A, Kadowitz, P J

“…Background and Purpose: Ephedrine and amphetamine can cause substantial increases in systemic arterial pressure. However, the role of endogenous noradrenaline…”
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Gene Transfer of Endothelial Nitric Oxide Synthase to the Lung of the Mouse In Vivo: Effect on Agonist-Induced and Flow-Mediated Vascular Responses by Champion, Hunter C, Bivalacqua, Trinity J, D'Souza, Fiona M, Ortiz, Luis A, Jeter, James R, Toyoda, Kazunori, Heistad, Donald D, Hyman, Albert L, Kadowitz, Philip J

“…The effects of transfer of the endothelial nitric oxide synthase (eNOS) gene to the lung were studied in mice. After intratracheal administration of AdCMVβgal,…”
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The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation by Ignarro, L J, Kadowitz, P J

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Peroxynitrite does not impair pulmonary and systemic vascular responses by Nossaman, B. D, Dabisch, P. A, Liles, J. T, Baber, S. R, Champion, H. C, Kaye, A. D, Feng, C.-J, Anwar, M, Bivalacqua, T. J, Santiago, J. A, De Witt, B. J, Kadowitz, P. J

“…Departments of Anesthesiology and Pharmacology, Tulane University Health Science Center, New Orleans, Louisiana 70112 Submitted 16 December 2002 ; accepted in…”
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Pulmonary vasodilator responses to adrenomedullin are reduced by NOS inhibitors in rats but not in cats by Nossaman, B D, Feng, C J, Kaye, A D, DeWitt, B, Coy, D H, Murphy, W A, Kadowitz, P J

“…Responses to and the mechanism of action of adrenomedullin (ADM), the carboxy-terminal fragments of ADM, and calcitonin gene-related peptide (CGRP), a…”
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