Search Results - "Kador, P F"

Asteroid hyalosis: pathogenesis and prospects for prevention by Kador, P F, Wyman, M

“…Asteroid hyalosis (AH) is a common degenerative process in which fatty calcium globules collect within the vitreous humour. The condition rarely causes visual…”
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Novel oral multifunctional antioxidant prevents noise-induced hearing loss and hair cell loss by Chen, G.D., Daszynski, D.M., Ding, D., Jiang, H., Woolman, T., Blessing, K., Kador, P.F., Salvi, R.

“…Oxidative stress is a major contributor to noise-induced hearing loss, the most common cause of hearing loss among military personnel and young adults. HK-2 is…”
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Selective pericyte degeneration in the retinal capillaries of galactose-fed dogs results from apoptosis linked to aldose reductase-catalyzed galactitol accumulation by Murata, M, Ohta, N, Fujisawa, S, Tsai, J.-Y, Sato, S, Akagi, Y, Takahashi, Y, Neuenschwander, H, Kador, P.F

“…Galactose-fed dogs develop retinal capillary changes similar to diabetic retinopathy with pericyte degeneration as the initial lesion. This is followed by the…”
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Ophthalmic opportunities for the medicinal chemist by Kador, P F

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Vascular endothelial growth factor (VEGF) enhances the expression of receptors and activates mitogen-activated protein (MAP) kinase of dog retinal capillary endothelial cells by Murata, M, Kador, P F, Sato, S

“…Since the galactose-fed dog is an animal model that develops the advanced stage of proliferative retinopathy, the effects of vascular endothelial growth factor…”
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Sorbitol, osmoregulation, and the complications of diabetes by BURG, M. B, KADOR, P. F

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Induction of Aldose Reductase and Sorbitol in Renal Inner Medullary Cells by Elevated Extracellular NaCl by Bagnasco, Serena M., Uchida, Shunya, Balaban, Robert S., Kador, Peter F., Burg, Maurice B.

“…Aldose reductase [aldehyde reductase 2; alditol:NAD(P)+1-oxidoreductase, EC 1.1.1.21] catalyzes conversion of glucose to sorbitol. Although its activity is…”
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Method for isolating tight-binding inhibitors of rat lens aldose reductase by Sun, G., Ma, Y., Gao, X., König, S., Fales, H.M., Kador, P.F.

“…Numerous animal studies indicate that aldose reductase inhibitors (ARIs) are beneficial for the prevention or amelioration of diabetic complications such as…”
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Polyol formation and NADPH-dependent reductases in dog retinal capillary pericytes and endothelial cells by Sato, S, Secchi, EF, Lizak, MJ, Fukase, S, Ohta, N, Murata, M, Tsai, JY, Kador, PF

“…Dogs fed a diet containing 30% galactose experience retinal vascular changes similar to those in human diabetic retinopathy, with selective pericyte loss as an…”
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Inhibition of aldehyde reductase by aldose reductase inhibitors by Sato, S, Kador, P F

“…A broad group of structurally diverse aldose reductase inhibitors including flavonoids, carboxylic acids and hydantoins, have been examined for their ability…”
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Synthesis of potential aldose reductase inhibitors based on minimal pharmacophore requirements by Schlitzer, Martin, Rodriguez, Labaniel, Kador, Peter F.

“…A series of 17 compounds were synthesized based on the premise that the minimal pharmacophore for aldose reductase inhibition requires the presence of both an…”
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MRI of the Human Eye Using Magnetization Transfer Contrast Enhancement by Lizak, Martin J, Datiles, Manuel B, Aletras, Anthony H, Kador, Peter F, Balaban, Robert S

“…To determine the feasibility of using magnetization transfer contrast-enhanced magnetic resonance imaging (MRI) to track cataractous lens changes. A fast…”
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Dose-Dependent Prevention of Sugar Cataracts in Galactose-fed Dogs by the Aldose Reductase Inhibitor M79175 by SATO, SANAI, MORI, KAZUHIKO, WYMAN, MILTON, KADOR, PETER F.

“…Sugar cataracts rapidly develop in dogs fed a diet containing 30% galactose. While studies on the formation and progression of these sugar cataracts suggest…”
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Progression of sugar cataract in the dog by Sato, S, Takahashi, Y, Wyman, M, Kador, PF

“…Young beagle dogs were fed a 30% galactose diet, with or without the aldose reductase inhibitors sorbinil or M79175. Cataract formation was monitored by…”
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The pharmacology of aldose reductase inhibitors by Kador, P F, Robison, Jr, W G, Kinoshita, J H

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Isolation of a non-covalent aldose reductase–nucleotide–inhibitor complex by Sugiyama, Katsumi, Chen, Zhou, Lee, Yong S., Kador, Peter F.

“…A method for the isolation of an intact, non-covalent complex formed by the interaction of aldose reductase, NADP(H) nucleotide, and inhibitor has been…”
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Fine-structural localization of aldose reductase and ouabain-sensitive, K+-dependent p-nitro-phenylphosphatase in rat peripheral nerve by POWELL, H. C, GARRETT, R. S, KADOR, P. F, MIZISIN, A. P

“…Aldose reductase was visualized by light and electron microscopy using a goat anti-rat antibody with immunoperoxidase and immunogold, respectively…”
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Dose-dependent reduction of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by the aldose reductase inhibitor M79175 by Neuenschwander, H, Takahashi, Y, Kador, P F

“…The onset and progression of retinal vascular changes associated with early diabetic retinopathy has been delayed in beagles fed 30% galactose diet for 38…”
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Localization of aldose and aldehyde reductase in the kidney by Terubayashi, Hirofumi, Sato, Sanai, Nishimura, Chihiro, Kador, Peter F., Kinoshita, Jin H.

“…Localization of aldose and aldehyde reductase in the kidney. The distribution of NADPH-dependent reductase activity in the rat cortex, outer medulla and inner…”
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Aldose reductase, a key enzyme in the oxidative deamination of norepinephrine in rats by Kawamura, Minoru, Eisenhofer, Graeme, Kopin, Irwin J, Kador, Peter F, Lee, Yong S, Tsai, Jen-Yue, Fujisawa, Shigeki, Lizak, Martin J, Sinz, Andrea, Sato, Sanai

“…The sympathoneural neurotransmitter norepinephrine (NE) is deaminated to 3,4-dihydroxymandelaldehyde (DHMAL) and subsequently converted to either…”
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