Search Results - "Kadlubar, F F"

Processed meat intake, CYP2A6 activity and risk of colorectal adenoma by Ward, Mary H., Cross, Amanda J., Divan, Hozefa, Kulldorff, Martin, Nowell-Kadlubar, Susan, Kadlubar, Fred F., Sinha, Rashmi

“…Red and processed meat intake is associated with increased risks of both colorectal adenoma and cancer. Processed meats contain nitrate and nitrite, precursors…”
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Human alpha class glutathione S-transferases: genetic polymorphism, expression, and susceptibility to disease by Coles, Brian F, Kadlubar, Fred F

“…The human alpha class glutathione S-transferases (GSTs) consist of 5 genes, hGSTA1-hGSTA5, and 7 pseudogenes on chromosome 6p12.1-6p12.2. hGSTA1-hGSTA4 have…”
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Physical Activity, Diet, and Pancreatic Cancer: A Population-Based, Case-Control Study in Minnesota by Zhang, Jianjun, Dhakal, Ishwori B., Gross, Myron D., Lang, Nicholas P., Kadlubar, Fred F., Harnack, Lisa J., Anderson, Kristin E.

“…Although mounting evidence suggests that insulin resistance is involved in pancreatic carcinogenesis, few epidemiologic studies have comprehensively…”
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Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients by NOWELL, Susan A, AHN, Jiyoung, RAE, James M, SCHEYS, Joshua O, TROVATO, Andrew, SWEENEY, Carol, MACLEOD, Stewart L, KADLUBAR, Fred F, AMBROSONE, Christine B

“…Tamoxifen has been a mainstay of adjuvant therapy for breast cancer for many years. We sought to determine if genetic variability in the tamoxifen metabolic…”
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p53 Genotypes and Haplotypes Associated With Lung Cancer Susceptibility and Ethnicity by Wu, Xifeng, Zhao, Hua, Amos, Christopher I., Shete, Sanjay, Makan, Nimisha, Hong, Waun K., Kadlubar, Fred F., Spitz, Margaret R.

“…Background: The p53 tumor suppressor protein is important in cell-cycle control, apoptosis, and DNA repair. Mutations in p53 have been associated with…”
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Identification of Functional Genetic Variants in Cyclooxygenase-2 and Their Association With Risk of Esophageal Cancer by Zhang, Xuemei, Miao, Xiaoping, Tan, Wen, Ning, Baitang, Liu, Zhihua, Hong, Yuan, Song, Wenguang, Guo, Yongli, Zhang, Xinyu, Shen, Yan, Qiang, Boqin, Kadlubar, Fred F., Lin, Dongxin

“…Background & Aims: Overexpression of cyclooxygenase-2 (COX-2) is implicated in many steps of cancer development. Single nucleotide polymorphisms (SNPs) in the…”
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Identification of Aminobiphenyl Derivatives in Commercial Hair Dyes by Turesky, Robert J, Freeman, James P, Holland, Ricky D, Nestorick, Daniel M, Miller, Dwight W, Ratnasinghe, D. Luke, Kadlubar, Fred F

“…A recent epidemiological study suggested that aromatic amines present in hair dyes may contribute to an increased risk of bladder cancer (Gago-Dominguez, et…”
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In Situ Hybridization and Immunohistochemical Analysis of Cytochrome P450 1B1 Expression in Human Normal Tissues by Muskhelishvili, Levan, Thompson, Patricia A, Kusewitt, Donna F, Wang, Charles, Kadlubar, Fred F

“…SUMMARY Cytochrome P450 1B1 (CYP1B1) is a recently cloned dioxin-inducible form of the cytochrome P450 supergene family of xenobiotic-metabolizing enzymes…”
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Detoxification of electrophilic compounds by glutathione S-transferase catalysis: Determinants of individual response to chemical carcinogens and chemotherapeutic drugs? by Coles, Brian F., Kadlubar, Fred F.

“…The glutathione S‐transferases (GSTs) catalyze the GSH‐dependent detoxification of reactive electrophiles such as genotoxic chemical carcinogens and cytotoxic…”
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Dietary Intake of Heterocyclic Amines and Benzo(a)Pyrene: Associations with Pancreatic Cancer by ANDERSON, Kristin E, KADLUBAR, Fred F, KULLDORFF, Martin, HARNACK, Lisa, GROSS, Myron, LANG, Nicholas P, BARBER, Cheryl, ROTHMAN, Nat, SINHA, Rashmi

“…Objective: Heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons, formed in temperature- and time-dependent manners during the cooking of meat, are…”
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Associations between Catalase Phenotype and Genotype: Modification by Epidemiologic Factors by AHN, Jiyoung, NOWELL, Susan, MCCANN, Susan E, YU, Jihnhee, CARTER, Lisa, LANG, Nicholas P, KADLUBAR, Fred F, RATNASINGHE, Luke D, AMBROSONE, Christine B

“…Catalase is an endogenous antioxidant enzyme that neutralizes hydrogen peroxide and is induced by oxidative challenge. A −262C → T polymorphism in the promoter…”
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Impact of Genetic Polymorphisms in Cytochrome P450 2E1 and Glutathione S-Transferases M1, T1, and P1 on Susceptibility to Esophageal Cancer among High-Risk Individuals in China by Tan, W, Song, N, Wang, G Q, Liu, Q, Tang, H J, Kadlubar, F F, Lin, D X

“…Esophageal cancer, which is prevalent in China, is believed to be induced by environmental carcinogens such as nitrosamines and other agents. The…”
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Hair dye use, meat intake, and tobacco exposure and presence of carcinogen-DNA adducts in exfoliated breast ductal epithelial cells by Ambrosone, Christine B., Abrams, Sara M., Gorlewska-Roberts, Katarzyna, Kadlubar, Fred F.

“…Diet and environmental exposures to aromatic and heterocyclic amines, and polycyclic aromatic hydrocarbons, are thought to be etiologic factors for breast…”
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Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps by Lang, N P, Butler, M A, Massengill, J, Lawson, M, Stotts, R C, Hauer-Jensen, M, Kadlubar, F F

“…The metabolic activation of food-borne heterocyclic amines to colon carcinogens in humans is hypothesized to occur via N-oxidation followed by O-acetylation to…”
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Synergic Effect of Polymorphisms in ERCC6 5' Flanking Region and Complement Factor H on Age-Related Macular Degeneration Predisposition by Tuo, Jingsheng, Ning, Baitang, Bojanowski, Christine M., Lin, Zhong-Ning, Ross, Robert J., Reed, George F., Shen, Defen, Jiao, Xiaodong, Zhou, Min, Chew, Emily Y., Kadlubar, Fred F., Chan, Chi-Chao

“…This study investigates age-related macular degeneration (AMD) genetic risk factors through identification of a functional single-nucleotide polymorphism (SNP)…”
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Polymorphisms in glutathione S-transferases (GSTM1 and GSTT1) and survival after treatment for breast cancer by AMBROSONE, Christine B, SWEENEY, Carol, COLES, Brian F, THOMPSON, Patricia A, MCCLURE, Gail Y, KOROURIAN, Soheila, FARES, Manal Y, STONE, Angie, KADLUBAR, Fred F, HUTCHINS, Laura F

“…The response to treatment for breast cancer is likely predicted by a number of disease and tumor tissue characteristics, many of which are under active…”
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Susceptibility to esophageal cancer and genetic polymorphisms in glutathione S-transferases T1, P1, and M1 and cytochrome P450 2E1 by Lin, D X, Tang, Y M, Peng, Q, Lu, S X, Ambrosone, C B, Kadlubar, F F

“…Genetic polymorphisms in enzymes involved in carcinogen metabolism have been shown to influence susceptibility to cancer. Cytochrome P450 2E1 (CYP2E1) is…”
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Deletion Polymorphism of UDP-Glucuronosyltransferase 2B17 and Risk of Prostate Cancer in African American and Caucasian Men by Park, Jong, Chen, Lan, Ratnashinge, Luke, Sellers, Thomas A, Tanner, Jean-Paul, Lee, Ji-Hyun, Dossett, Nicole, Lang, Nicholas, Kadlubar, Fred F, Ambrosone, Christine B, Zachariah, Babu, Heysek, Randy V, Patterson, Stephen, Pow-Sang, Julio

“…Purpose: UDP-glucuronosyltransferases (UGT) are a family of enzymes that glucuronidate many endogenous chemicals, including androgens. This makes them more…”
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Carcinogen substrate specificity of human COX-1 and COX-2 by Wiese, Frederick W., Thompson, Patricia A., Kadlubar, Fred F.

“…The activation of carcinogenic aromatic and heterocyclic amines and benzo[a]pyrene-7,8-diol to intracellular electrophiles by prostaglandin H synthase (COX) is…”
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CYP2A13 expressed in human bladder metabolically activates 4‐aminobiphenyl by Nakajima, Miki, Itoh, Masahiro, Sakai, Haruko, Fukami, Tatsuki, Katoh, Miki, Yamazaki, Hiroshi, Kadlubar, Fred F., Imaoka, Susumu, Funae, Yoshihiko, Yokoi, Tsuyoshi

“…Cigarette smoking is the predominant risk factor for bladder cancer. Aromatic amines such as 4‐aminobiphenyl (ABP) is the major carcinogens found in tobacco…”
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