Search Results - "Kadlof, Michal"
-
1
Chromatin image-driven modelling
Published in Methods (San Diego, Calif.) (01-06-2024)“…The challenge of modelling the spatial conformation of chromatin remains an open problem. While multiple data-driven approaches have been proposed, each has…”
Get full text
Journal Article -
2
Complex lasso: new entangled motifs in proteins
Published in Scientific reports (22-11-2016)“…We identify new entangled motifs in proteins that we call complex lassos. Lassos arise in proteins with disulfide bridges (or in proteins with amide linkages),…”
Get full text
Journal Article -
3
Machine learning polymer models of three-dimensional chromatin organization in human lymphoblastoid cells
Published in Methods (San Diego, Calif.) (15-08-2019)“…•Prediction of chromatin interactions from chromatin state and sequence information.•Significant features are gene counts and signal of interaction mediating…”
Get full text
Journal Article -
4
Ultrastructural visualization of 3D chromatin folding using volume electron microscopy and DNA in situ hybridization
Published in Nature communications (01-05-2020)“…The human genome is extensively folded into 3-dimensional organization. However, the detailed 3D chromatin folding structures have not been fully visualized…”
Get full text
Journal Article -
5
Computational modelling of three-dimensional genome structure
Published in Methods (San Diego, Calif.) (01-10-2020)Get full text
Journal Article -
6
Spring Model – Chromatin Modeling Tool Based on OpenMM
Published in Methods (San Diego, Calif.) (01-10-2020)“…•Prediction of chromatin three dimensional conformation within genomic domains using verified 2D interactions from ChIA-PET or Hi-C experiments.•Simulations’…”
Get full text
Journal Article -
7
3D-GNOME 3.0: a three-dimensional genome modelling engine for analysing changes of promoter-enhancer contacts in the human genome
Published in Nucleic acids research (05-07-2023)“…Abstract In the current update, we added a feature for analysing changes in spatial distances between promoters and enhancers in chromatin 3D model ensembles…”
Get full text
Journal Article -
8
3D-GNOME: an integrated web service for structural modeling of the 3D genome
Published in Nucleic acids research (08-07-2016)“…Recent advances in high-throughput chromosome conformation capture (3C) technology, such as Hi-C and ChIA-PET, have demonstrated the importance of 3D genome…”
Get full text
Journal Article -
9
GapRepairer: a server to model a structural gap and validate it using topological analysis
Published in Bioinformatics (01-10-2018)“…Abstract Motivation Over 25% of protein structures possess unresolved fragments. On the other hand, approximately 6% of protein chains have non-trivial…”
Get full text
Journal Article