Search Results - "Kadlčík, Stanislav"

Adaptation of an L-proline adenylation domain to use 4-propyl-L-proline in the evolution of lincosamide biosynthesis by Kadlčík, Stanislav, Kučera, Tomáš, Chalupská, Dominika, Gažák, Radek, Koběrská, Markéta, Ulanová, Dana, Kopecký, Jan, Kutejová, Eva, Najmanová, Lucie, Janata, Jiří

“…Clinically used lincosamide antibiotic lincomycin incorporates in its structure 4-propyl-L-proline (PPL), an unusual amino acid, while celesticetin, a less…”
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Mutasynthesis of Lincomycin Derivatives with Activity against Drug-Resistant Staphylococci by ULANOVA, Dana, NOVOTNA, Jitka, SMUTNA, Yvona, KAMENIK, Zdeněk, GAZAK, Radek, SULC, Miroslav, SEDMERA, Petr, KADLCIK, Stanislav, PLHACKOVA, Kamila, JANATA, Jiří

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Evolution-guided adaptation of an adenylation domain substrate specificity to an unusual amino acid by Vobruba, Simon, Kadlcik, Stanislav, Gazak, Radek, Janata, Jiri

“…Adenylation domains CcbC and LmbC control the specific incorporation of amino acid precursors in the biosynthesis of lincosamide antibiotics celesticetin and…”
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C-C bond cleavage in biosynthesis of 4-alkyl-L-proline precursors of lincomycin and anthramycin cannot precede C-methylation by Kamenik, Zdenek, Gazak, Radek, Kadlcik, Stanislav, Steiningerova, Lucie, Rynd, Vit, Janata, Jiri

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Deacetylation of mycothiol-derived 'waste product' triggers the last biosynthetic steps of lincosamide antibiotics by Kamenik, Zdenek, Kadlcik, Stanislav, Radojevic, Bojana, Jiraskova, Petra, Kuzma, Marek, Gazak, Radek, Najmanova, Lucie, Kopecky, Jan, Janata, Jiri

“…The immediate post-condensation steps in lincomycin biosynthesis are reminiscent of the mycothiol-dependent detoxification system of actinomycetes. This…”
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Lincosamide synthetase--a unique condensation system combining elements of nonribosomal peptide synthetase and mycothiol metabolism by Janata, Jiri, Kadlcik, Stanislav, Koberska, Marketa, Ulanova, Dana, Kamenik, Zdenek, Novak, Petr, Kopecky, Jan, Novotna, Jitka, Radojevic, Bojana, Plhackova, Kamila, Gazak, Radek, Najmanova, Lucie

“…In the biosynthesis of lincosamide antibiotics lincomycin and celesticetin, the amino acid and amino sugar units are linked by an amide bond. The respective…”
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Structure‐Function Analysis of the S‐Glycosylation Reaction in the Biosynthesis of Lincosamide Antibiotics by Mori, Takahiro, Sun, Xin, Kadlcik, Stanislav, Janata, Jiri, Abe, Ikuro

“…The S‐glycosyltransferase LmbT, involved in the biosynthesis of lincomycin A, is the only known enzyme that catalyzes the enzymatic incorporation of rare amino…”
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TldD/TldE peptidases and N-deacetylases: A structurally unique yet ubiquitous protein family in the microbial metabolism by Vobruba, Simon, Kadlcik, Stanislav, Janata, Jiri, Kamenik, Zdenek

“…Here we provide a review on TldD/TldE family proteins, summarizing current knowledge and outlining further research perspectives. Despite being widely…”
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Different Reaction Specificities of F420H2‑Dependent Reductases Facilitate Pyrrolobenzodiazepines and Lincomycin To Fit Their Biological Targets by Steiningerova, Lucie, Kamenik, Zdenek, Gazak, Radek, Kadlcik, Stanislav, Bashiri, Ghader, Man, Petr, Kuzma, Marek, Pavlikova, Magdalena, Janata, Jiri

“…Antitumor pyrrolo­benzo­di­azepines (PBDs), lincosamide antibiotics, quorum-sensing molecule hormaomycin, and antimicrobial griselimycin are structurally and…”
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N‑Deacetylation in Lincosamide Biosynthesis Is Catalyzed by a TldD/PmbA Family Protein by Vobruba, Simon, Kamenik, Zdenek, Kadlcik, Stanislav, Janata, Jiri

“…Lincosamides are clinically important antibiotics originally produced as microbial specialized metabolites. The complex biosynthesis of lincosamides is coupled…”
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Novel pathway of 3-hydroxyanthranilic acid formation in limazepine biosynthesis reveals evolutionary relation between phenazines and pyrrolobenzodiazepines by Pavlikova, Magdalena, Kamenik, Zdenek, Janata, Jiri, Kadlcik, Stanislav, Kuzma, Marek, Najmanova, Lucie

“…Natural pyrrolobenzodiazepines (PBDs) form a large and structurally diverse group of antitumour microbial metabolites produced through complex pathways, which…”
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Structure‐Function Analysis of the S‐Glycosylation Reaction in the Biosynthesis of Lincosamide Antibiotics by Mori, Takahiro, Sun, Xin, Kadlcik, Stanislav, Janata, Jiri, Abe, Ikuro

“…The S‐glycosyltransferase LmbT, involved in the biosynthesis of lincomycin A, is the only known enzyme that catalyzes the enzymatic incorporation of rare amino…”
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Different Reaction Specificities of F 420 H 2 -Dependent Reductases Facilitate Pyrrolobenzodiazepines and Lincomycin To Fit Their Biological Targets by Steiningerova, Lucie, Kamenik, Zdenek, Gazak, Radek, Kadlcik, Stanislav, Bashiri, Ghader, Man, Petr, Kuzma, Marek, Pavlikova, Magdalena, Janata, Jiri

“…Antitumor pyrrolobenzodiazepines (PBDs), lincosamide antibiotics, quorum-sensing molecule hormaomycin, and antimicrobial griselimycin are structurally and…”
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Diversity of Alkylproline Moieties in Pyrrolobenzodiazepines Arises from Postcondensation Modifications of a Unified Building Block by Kamenik, Zdenek, Kadlcik, Stanislav, Gazak, Radek, Vobruba, Simon, Palanova, Lucie, Kuzma, Marek, Janata, Jiri

“…Anticancer pyrrolobenzodiazepines (PBDs) are one of several groups of natural products that contain unusual 4-alkyl-l-proline derivatives (APDs) in their…”
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Molecular basis for carrier protein-dependent amide bond formation in the biosynthesis of lincosamide antibiotics by Mori, Takahiro, Kadlcik, Stanislav, Lyu, Shuang, Kamenik, Zdenek, Sakurada, Kosuke, Mazumdar, Aninda, Wang, Huibin, Janata, Jiri, Abe, Ikuro

“…In the biosynthesis of the lincosamide antibiotic celesticetin, the condensation enzyme CcbD generates the lincosamide pharmacophore by forming an amide bond…”
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New Concept of the Biosynthesis of 4-Alkyl-L-Proline Precursors of Lincomycin, Hormaomycin, and Pyrrolobenzodiazepines: Could a γ-Glutamyltransferase Cleave the C-C Bond? by Jiraskova, Petra, Gazak, Radek, Kamenik, Zdenek, Steiningerova, Lucie, Najmanova, Lucie, Kadlcik, Stanislav, Novotna, Jitka, Kuzma, Marek, Janata, Jiri

“…Structurally different and functionally diverse natural compounds - antitumour agents pyrrolo[1,4]benzodiazepines, bacterial hormone hormaomycin, and…”
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Comparative analysis of oligonucleotide primers for high-throughput screening of genes encoding adenylation domains of nonribosomal peptide synthetases in actinomycetes by Bakal, Tomas, Goo, Kian-Sim, Najmanova, Lucie, Plhackova, Kamila, Kadlcik, Stanislav, Ulanova, Dana

“…In the biosynthesis of diverse natural bioactive products the adenylation domains (ADs) of nonribosomal peptide synthetases select specific precursors from the…”
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Deacetylation of mycothiol-derived 'waste product' triggers the last biosynthetic steps of lincosamide antibioticsElectronic supplementary information (ESI) available: Experimental procedures, additional figures, chromatograms and NMR data. See DOI: 10.1039/c5sc03327f by Kamenik, Zdenek, Kadlcik, Stanislav, Radojevic, Bojana, Jiraskova, Petra, Kuzma, Marek, Gazak, Radek, Najmanova, Lucie, Kopecky, Jan, Janata, Jiri

“…The immediate post-condensation steps in lincomycin biosynthesis are reminiscent of the mycothiol-dependent detoxification system of actinomycetes. This…”
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Deacetylation of mycothiol-derived ‘waste product’ triggers the last biosynthetic steps of lincosamide antibiotics† †Electronic supplementary information (ESI) available: Experimental procedures, additional figures, chromatograms and NMR data. See DOI: 10.1039/c5sc03327f Click here for additional data file by Kamenik, Zdenek, Kadlcik, Stanislav, Radojevic, Bojana, Jiraskova, Petra, Kuzma, Marek, Gazak, Radek, Najmanova, Lucie, Kopecky, Jan, Janata, Jiri

“…Two homologous pyridoxal 5′-phosphate-dependent enzymes LmbF and CcbF transform the deacetylated S -cysteinyl residue of related intermediates in the…”
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