Search Results - "Kadiiska, Maria"

Role of oxidative stress in cadmium toxicity and carcinogenesis by Liu, Jie, Qu, Wei, Kadiiska, Maria B.

“…Cadmium (Cd) is a toxic metal, targeting the lung, liver, kidney, and testes following acute intoxication, and causing nephrotoxicity, immunotoxicity,…”
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Classifying oxidative stress by F 2 -isoprostane levels across human diseases: A meta-analysis by van 't Erve, Thomas J, Kadiiska, Maria B, London, Stephanie J, Mason, Ronald P

“…The notion that oxidative stress plays a role in virtually every human disease and environmental exposure has become ingrained in everyday knowledge. However,…”
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Classifying oxidative stress by F2-isoprostane levels across human diseases: A meta-analysis by van 't Erve, Thomas J., Kadiiska, Maria B., London, Stephanie J., Mason, Ronald P.

“…The notion that oxidative stress plays a role in virtually every human disease and environmental exposure has become ingrained in everyday knowledge. However,…”
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Reinterpreting the best biomarker of oxidative stress: The 8-iso-PGF(2α)/PGF(2α) ratio distinguishes chemical from enzymatic lipid peroxidation by van 't Erve, Thomas J, Lih, Fred B, Kadiiska, Maria B, Deterding, Leesa J, Eling, Thomas E, Mason, Ronald P

“…The biomarker 8-iso-prostaglandin F2α (8-iso-PGF2α) is regarded as the gold standard for detection of excessive chemical lipid peroxidation in humans. However,…”
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Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis by Chatterjee, Saurabh, Ganini, Douglas, Tokar, Erik J, Kumar, Ashutosh, Das, Suvarthi, Corbett, Jean, Kadiiska, Maria B, Waalkes, Michael P, Diehl, Anna Mae, Mason, Ronald P

“…Background & Aims Progression from steatosis to steatohepatitic lesions is hypothesized to require a second hit. These lesions have been associated with…”
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Formation and Implications of Alpha-Synuclein Radical in Maneb- and Paraquat-Induced Models of Parkinson’s Disease by Kumar, Ashutosh, Leinisch, Fabian, Kadiiska, Maria B., Corbett, Jean, Mason, Ronald P.

“…Parkinson’s disease (PD) is a debilitating, progressive, neurodegenerative disorder characterized by progressive loss of dopaminergic neurons and motor…”
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Ozone exposure effect on systemic prostaglandin F 2α in rat plasma and urine may not reveal pulmonary damage through inflammation by Basu, Samar, Kadiiska, Maria B

“…The acute ozone induced lung injury model has been widely used to explore injury and repair processes induced by oxidant overload. The current study evaluated…”
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Ozone exposure effect on systemic prostaglandin F2α in rat plasma and urine may not reveal pulmonary damage through inflammation by Basu, Samar, Kadiiska, Maria B.

“…The acute ozone induced lung injury model has been widely used to explore injury and repair processes induced by oxidant overload. The current study evaluated…”
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Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells by Kumar, Ashutosh, Chen, Shih-Heng, Kadiiska, Maria B., Hong, Jau-Shyong, Zielonka, Jacek, Kalyanaraman, Balaraman, Mason, Ronald P.

“…Microglia are the resident immune cells in the brain. Microglial activation is characteristic of several inflammatory and neurodegenerative diseases including…”
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Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice by Seth, Ratanesh Kumar, Kumar, Ashutosh, Das, Suvarthi, Kadiiska, Maria B, Michelotti, Gregory, Diehl, Anna Mae, Chatterjee, Saurabh

“…Obesity is associated with strong risks of development of chronic inflammatory liver disease and metabolic syndrome following a second hit. This study tests…”
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Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis by Pourhoseini, Sahar, Seth, Ratanesh Kumar, Das, Suvarthi, Dattaroy, Diptadip, Kadiiska, Maria B, Xie, Guanhua, Michelotti, Gregory A, Nagarkatti, Mitzi, Diehl, Anna Mae, Chatterjee, Saurabh

“…Sinusoidal endothelial dysfunction (SED) has been found to be an early event in nonalcoholic steatohepatitis (NASH) progression but the molecular mechanisms…”
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Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis by Das, Suvarthi, Seth, Ratanesh Kumar, Kumar, Ashutosh, Kadiiska, Maria B, Michelotti, Gregory, Diehl, Anna Mae, Chatterjee, Saurabh

“…Recent studies indicate that metabolic oxidative stress, autophagy, and inflammation are hallmarks of nonalcoholic steatohepatitis (NASH) progression. However,…”
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Reinterpreting the best biomarker of oxidative stress: The 8-iso-prostaglandin F2α/prostaglandin F2α ratio shows complex origins of lipid peroxidation biomarkers in animal models by van't Erve, Thomas J., Lih, Fred B., Jelsema, Casey, Deterding, Leesa J., Eling, Thomas E., Mason, Ronald P., Kadiiska, Maria B.

“…Oxidative stress is elevated in numerous environmental exposures and diseases. Millions of dollars have been spent to try to ameliorate this damaging process…”
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P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice by Chatterjee, Saurabh, Rana, Ritu, Corbett, Jean, Kadiiska, Maria B., Goldstein, Joyce, Mason, Ronald P.

“…While some studies show that carbon tetrachloride-mediated metabolic oxidative stress exacerbates steatohepatitic-like lesions in obese mice, the redox…”
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Elevated plasma 8-iso-prostaglandin F 2α levels in human smokers originate primarily from enzymatic instead of non-enzymatic lipid peroxidation by van 't Erve, Thomas J, Lih, Fred B, Kadiiska, Maria B, Deterding, Leesa J, Mason, Ronald P

“…It is widely accepted that free radicals in tobacco smoke lead to oxidative stress and generate the popular lipid peroxidation biomarker 8-iso-prostaglandin F…”
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Biomarkers of oxidative stress study VI. Endogenous plasma antioxidants fail as useful biomarkers of endotoxin-induced oxidative stress by Kadiiska, Maria B., Peddada, Shyamal, Herbert, Ronald A., Basu, Samar, Hensley, Kenneth, Jones, Dean P., Hatch, Gary E., Mason, Ronald P.

“…This is the newest report in a series of publications aiming to identify a blood-based antioxidant biomarker that could serve as an in vivo indicator of…”
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CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis by Seth, Ratanesh Kumar, Das, Suvarthi, Kumar, Ashutosh, Chanda, Anindya, Kadiiska, Maria B., Michelotti, Gregory, Manautou, Jose, Diehl, Anna Mae, Chatterjee, Saurabh

“…Environmental toxins induce a novel CYP2E1/leptin signaling axis in liver. This in turn activates a poorly characterized innate immune response that…”
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Proinflammatory adipokine leptin mediates disinfection byproduct bromodichloromethane-induced early steatohepatitic injury in obesity by Das, Suvarthi, Kumar, Ashutosh, Seth, Ratanesh Kumar, Tokar, Erik J., Kadiiska, Maria B., Waalkes, Michael P., Mason, Ronald P., Chatterjee, Saurabh

“…Today's developed world faces a major public health challenge in the rise in the obese population and the increased incidence in fatty liver disease. There is…”
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Ceruloplasmin (ferroxidase) oxidizes hydroxylamine probes: Deceptive implications for free radical detection by Ganini, Douglas, Canistro, Donatella, Jang, JinJie, Stadler, Krisztian, Mason, Ronald P., Kadiiska, Maria B.

“…Ceruloplasmin (ferroxidase) is a copper-binding protein known to promote Fe2+ oxidation in plasma of mammals. In addition to its classical ferroxidase…”
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Protein Radical Formation Resulting from Eosinophil Peroxidase-catalyzed Oxidation of Sulfite by Ranguelova, Kalina, Chatterjee, Saurabh, Ehrenshaft, Marilyn, Ramirez, Dario C., Summers, Fiona A., Kadiiska, Maria B., Mason, Ronald P.

“…Eosinophil peroxidase (EPO) is an abundant heme protein in eosinophils that catalyzes the formation of cytotoxic oxidants implicated in asthma, allergic…”
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