Search Results - "Kadidlo, Diane M."

Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity by Hippen, Keli L, Merkel, Sarah C, Schirm, Dawn K, Sieben, Christine M, Sumstad, Darin, Kadidlo, Diane M, McKenna, David H, Bromberg, Jonathan S, Levine, Bruce L, Riley, James L, June, Carl H, Scheinberg, Phillip, Douek, Daniel C, Miller, Jeffrey S, Wagner, John E, Blazar, Bruce R

“…Graft-versus-host disease (GVHD) is a frequent and severe complication after hematopoietic cell transplantation. Natural CD4(+)CD25(+) regulatory T cells…”
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Optimization of cGMP purification and expansion of umbilical cord blood–derived T-regulatory cells in support of first-in-human clinical trials by McKenna, David H, Sumstad, Darin, Kadidlo, Diane M, Batdorf, Bjorn, Lord, Colin J, Merkel, Sarah C, Koellner, Christine M, Curtsinger, Julie M, June, Carl H, Riley, James L, Levine, Bruce L, Miller, Jeffrey S, Brunstein, Claudio G, Wagner, John E, Blazar, Bruce R, Hippen, Keli L

“…Abstract Background aims Thymic-derived regulatory T cells (tTreg) are critical regulators of the immune system. Adoptive tTreg transfer is a curative therapy…”
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Successful "in-flight" activation of natural killer cells during long-distance shipping by Koepsell, Scott A., Kadidlo, Diane M., Fautsch, Susan, McCullough, Jeffrey, Klingemann, Hans, Wagner, John E., Miller, Jeffrey S., McKenna Jr, David H.

“…BACKGROUND: Natural killer (NK) cells have shown promise in the treatment of malignancy. However, the widespread use of these cells may be limited by both the…”
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Good manufacturing practices production of natural killer cells for immunotherapy: a six-year single-institution experience by McKenna Jr, David H., Sumstad, Darin, Bostrom, Nancy, Kadidlo, Diane M., Fautsch, Susan, McNearney, Sarah, DeWaard, Rose, McGlave, Philip B., Weisdorf, Daniel J., Wagner, John E., McCullough, Jeffrey, Miller, Jeffrey S.

“…BACKGROUND: Natural killer (NK) cells, a subset of lymphocytes and part of the innate immune system, play a crucial role in defense against cancer and viral…”
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Clinical production and therapeutic applications of alloreactive natural killer cells by McKenna, David H, Kadidlo, Diane M, Cooley, Sarah, Miller, Jeffrey S

“…Recent advances have improved our understanding of natural killer (NK) cell-mediated alloreactivity after hematopoietic cell transplantation (HCT) or with…”
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The Minnesota Molecular and Cellular Therapeutics Facility: A State-of-the-Art Biotherapeutics Engineering Laboratory by McKenna, David H., Kadidlo, Diane M., Miller, Jeffrey S., Orchard, Paul J., Wagner, John E., McCullough, Jeffrey

“…Molecular-, gene-, cellular-, and tissue-based therapies have become increasingly acceptable modes of clinical therapy. Regulatory requirements and oversight…”
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Cellular engineering of HSV-tk transduced, expanded T lymphocytes for graft-versus-host disease management by Burger, Scott R, Kadidlo, Diane M, Basso, Lisa, Bostrom, Nancy, Orchard, Paul J

“…Engineering donor T lymphocytes with inducible 'suicide genes', such as herpes simplex virus thymidine kinase, has potential to improve safety and efficacy in…”
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