Search Results - "Kadayat, Tara"

Potent inhibitory activity of hydroxylated 2-benzylidene-3,4-dihydronaphthalen-1(2H)-ones on LPS-stimulated reactive oxygen species production in RAW 264.7 macrophages by Kunwar, Surendra, Min Lee, Su, Man Kadayat, Tara, Shrestha, Aarajana, Park, Pil-Hoon, Lee, Eung-Seok

“…[Display omitted] •Sixty-six 2-benzylidene-3,4-dihydronaphthalen-1(2H)-ones were synthesized.•6 and 7‑Hydroxyl substituents exhibited potent ROS inhibitory…”
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Di-indenopyridines as topoisomerase II-selective anticancer agents: Design, synthesis, and structure–activity relationships by Shrestha, Aarajana, Hwang, Soo-Yeon, Kunwar, Surendra, Man Kadayat, Tara, Park, Seojeong, Liu, Yi, Jo, Hyunji, Sheen, Naeun, Seo, Minjung, Lee, Eung-Seok, Kwon, Youngjoo

“…[Display omitted] •Twenty-three novel di-indeno[1,2-b]pyridines were synthesized.•Di- and tri-hydroxylation on di-indenopyridines were favorable for the topo…”
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4-Flourophenyl-substituted 5H-indeno[1,2-b]pyridinols with enhanced topoisomerase IIα inhibitory activity: Synthesis, biological evaluation, and structure–activity relationships by Kunwar, Surendra, Hwang, Soo-Yeon, Katila, Pramila, Seo, Minjung, Man Kadayat, Tara, Kwon, Youngjoo, Lee, Eung-Seok

“…[Display omitted] •Thirty six 4-flourophenyl-substituted 5H-indeno[1,2-b]pyridinols were synthesized.•Majority of compounds displayed potent topo IIα…”
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Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety by Thapa, Pritam, Karki, Radha, Yun, Minho, Kadayat, Tara Man, Lee, Eunyoung, Kwon, Han Byeol, Na, Younghwa, Cho, Won-Jea, Kim, Nam Doo, Jeong, Byeong-Seon, Kwon, Youngjoo, Lee, Eung-Seok

“…We have designed and synthesized a series of 2,4,6-triaryl pyridine derivatives containing chlorophenyl and phenolic moeity at 2- and 4- position of the…”
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Design, synthesis, biological evaluation, structure-activity relationship study, and mode of action of 2-phenol-4,6-dichlorophenyl-pyridines by Shrestha, Aarajana, Park, Seojeong, Shin, Somin, Man Kadayat, Tara, Bist, Ganesh, Katila, Pramila, Kwon, Youngjoo, Lee, Eung-Seok

“…[Display omitted] •2-Phenol-4,6-dichlorophenyl-substituted pyridines (1–27) were designed and synthesized.•Compounds (1–18) exhibited potent and selective topo…”
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Synthesis of a unique dimethyl thiazoline containing intermediate of novel peroxisome proliferator-activated receptors(PPAR)δ agonists by Man Kadayat, Tara, Lee, Geumwoo, Jung, Kyungjin, Hwang, Hee-Jong, Joo, Jeongmin, Hahn, Dongyup, Hwang, Hayoung, Park, Keun-Gyu, Cho, Sung Jin, Kim, Kyung-Hee, Chin, Jungwook

“…[Display omitted] •Method for unique dimethyl thiazoline containing intermediate of PPARδ agonists.•TBAHS as catalyst for efficient coupling of 11 with…”
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Targeting Peroxisome Proliferator-Activated Receptor Delta (PPARδ): A Medicinal Chemistry Perspective by Kadayat, Tara Man, Shrestha, Aarajana, Jeon, Yong Hyun, An, Hongchan, Kim, Jina, Cho, Sung Jin, Chin, Jungwook

“…One of the three subtypes of the peroxisome proliferator-activated receptor (PPAR) functioning as a transcription factor is the PPARβ or PPARδ. PPARδ is…”
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Antioxidative and anti-inflammatory activity of psiguadial B and its halogenated analogues as potential neuroprotective agents by Man Kadayat, Tara, Eun Kim, Dong, Bong Lee, Sang, Jung, Kyungjin, Eun Park, Sang, Hong, Ji-Ye, Kim, Jina, Shrestha, Aarajana, Kim, Dong-Su, An, Hongchan, Kim, Nayeon, Lee, Su-Jeong, Kwon, Sugyeong, Kim, Suhui, Yeon Hwang, Jun, Kim, Shinae, Hahn, Dongyup, Choi, Hyukjae, Nam, Sang-Jip, Hyun Jeon, Yong, Jin Hwang, Jung, Jin Cho, Sung, Chin, Jungwook

“…[Display omitted] •Psiguadial B and its halogenated derivatives were synthesized.•Synthetic route involved a simple and one-step reaction with inexpensive…”
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HIGHLY POTENT AND SELECTIVE PPAR DELTA AGONIST REVERSES MEMORY DEFICITS IN ALZHEIMER'S DISEASE MOUSE MODELS by Kim, Hyeon Jeong, Kim, Haelee, Song, Jaeyoung, Hong, Jun Young, Lee, Elijah, Choi, Ji Won, Park, Sun Jun, Yoon, Heeseok, Hwang, Hoosang, Hahn, Dongyup, Jung, Kyungjin, Kwon, Sugyeong, Kadayat, Tara, Ma, Min Jung, Joo, Jeongmin, Bae, Jae Hyun, Park, Jong-Hyun, Hwang, Hayoung, Cho, Sung Jin, Chin, Jungwook, Kang, Heonjoong, Park, Ki Duk

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Topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines by Karki, Radha, Song, Chanju, Kadayat, Tara Man, Magar, Til Bahadur Thapa, Bist, Ganesh, Shrestha, Aarajana, Na, Younghwa, Kwon, Youngjoo, Lee, Eung-Seok

“…Total thirty-six dihydroxylated 2,6-diphenyl-4-aryl pyridines were designed, synthesized and tested for topo I and II inhibitory activity and cytotoxicity for…”
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An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer by Kim, Jina, Hwang, Hayoung, Yoon, Heeseok, Lee, Jae-Eon, Oh, Ji Min, An, Hongchan, Ji, Hyun Dong, Lee, Seungmi, Cha, Eunju, Ma, Min Jung, Kim, Dong-Su, Lee, Su-Jeong, Kadayat, Tara Man, Song, Jaeyoung, Lee, Sang Woo, Jeon, Jae-Han, Park, Keun-Gyu, Lee, In-Kyu, Jeon, Yong Hyun, Chin, Jungwook, Cho, Sung Jin

“…Estrogen-related receptor gamma (ERRγ) is the NR3B subgroup of associated transcription factors. In this report, a new generation of a potent and selective…”
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Dihydroxylated 2,4,6-triphenyl pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study by Karki, Radha, Thapa, Pritam, Yoo, Han Young, Kadayat, Tara Man, Park, Pil-Hoon, Na, Youngwha, Lee, Eunyoung, Jeon, Kyung-Hwa, Cho, Won-Jea, Choi, Heesung, Kwon, Youngjoo, Lee, Eung-Seok

“…Twelve dihydroxylated 2,4,6-triphenyl pyridines were designed and synthesized which contain hydroxyl groups at ortho, meta or para position of 2- and 6-phenyl,…”
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Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents by Thapa, Pritam, Kadayat, Tara Man, Park, Seojeong, Shin, Somin, Thapa Magar, Til Bahadur, Bist, Ganesh, Shrestha, Aarajana, Na, Younghwa, Kwon, Youngjoo, Lee, Eung-Seok

“…[Display omitted] •Thirty-six 2-phenol-4-chlorophenyl-6-aryl pyridines were synthesized.•Evaluated for topo I and II inhibitory activity, and…”
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Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist by Lee, Su-Jeong, Samala, Mallesham, Woo, Seo Yeon, Hahn, Dongyup, Kim, Dayoung, Kadayat, Tara Man, Jung, Kyungjin, Kim, Jina, Kim, Dong-Su, Kwon, Sugyeong, Kim, Shinae, Kim, Kyung-Hee, Nam, Sang-Jip, Cho, Sung Jin, Chin, Jungwook

“…The convergent and enantioselective synthesis of a highly potent human peroxisome proliferator-activated receptor delta agonist is presented. More…”
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Targeting the Nuclear Receptor-Binding SET Domain Family of Histone Lysine Methyltransferases for Cancer Therapy: Recent Progress and Perspectives by Shrestha, Aarajana, Kim, Nayeon, Lee, Su-Jeong, Jeon, Yong Hyun, Song, Ji-Joon, An, Hongchan, Cho, Sung Jin, Kadayat, Tara Man, Chin, Jungwook

“…Nuclear receptor-binding SET domain (NSD) proteins are a class of histone lysine methyltransferases (HKMTases) that are amplified, mutated, translocated, or…”
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Antitrypanosomal Chloronitrobenzamides by Carrillo, Angela K., Kadayat, Tara Man, Hwang, Jong Yeon, Chen, Yizhe, Zhu, Fangyi, Holbrook, Gloria, Gillingwater, Kirsten, Connelly, Michele C., Yang, Lei, Kaiser, Marcel, Guy, R. Kiplin

“…Human African trypanosomiasis (HAT), a neglected tropical disease caused by Trypanosoma brucei gambiense (Tbg) or Trypanosoma brucei rhodesiense (Tbr), remains…”
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Synthesis and biological evaluation of 4,7,9-trisubstituted benzoxazepines as antileishmanial agents by Kadayat, Tara Man, Kwiatkowski, Stefan, Ortiz, Diana, Shoeran, Gaurav, Hammill, Jared T., Kim, Ho Shin, Cholewo, Joanna, Landfear, Scott M., Kiplin Guy, R.

“…[Display omitted] •New anti-leishmanial chemotypes.•Leishmania lead validation.•Leishmania structure–activity relationships.•Leishmania pharmacophore. Herein…”
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Discovery of the therapeutic potential of PPARδ agonist bearing 1,3,4- thiadiazole in inflammatory disorders by Kim, Jina, Kadayat, Tara Man, Lee, Jae-Eon, Kwon, Sugyeong, Jung, Kyungjin, Hwang, Ji Sun, Kwon, Oh-bin, Kim, Ye Jin, Choi, Yeon-Kyung, Park, Keun-Gyu, Hwang, Hayoung, Cho, Sung Jin, Lee, Taeho, Jeon, Yong Hyun, Chin, Jungwook

“…As a defense mechanism against deleterious stimuli, inflammation plays a vital role in the development of many disorders, including atherosclerosis,…”
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Topoisomerase IIα inhibitory and antiproliferative activity of dihydroxylated 2,6-diphenyl-4-fluorophenylpyridines: Design, synthesis, and structure-activity relationships by Kunwar, Surendra, Hwang, Soo-Yeon, Katila, Pramila, Man Kadayat, Tara, Jung, Ah-Reum, Kwon, Youngjoo, Lee, Eung-Seok

“…[Display omitted] •Synthesis of fluorine functionalities substituted 2,4,6-triphenylpyridines.•Strong antiproliferative activity by compounds 11, 12, 37, 50,…”
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A Series of Novel Terpyridine-Skeleton Molecule Derivants Inhibit Tumor Growth and Metastasis by Targeting Topoisomerases by Kwon, Han-Byeol, Park, Chanmi, Jeon, Kyung-Hwa, Lee, Eunyoung, Park, So-Eun, Jun, Kyu-Yeon, Kadayat, Tara Man, Thapa, Pritam, Karki, Radha, Na, Younghwa, Park, Mi Sun, Rho, Seung Bae, Lee, Eung-Seok, Kwon, Youngjoo

“…A series of novel terpyridine-skeleton molecules containing conformational rigidity, 14 containing benzo[4,5]furo[3,2-b]pyridine core and 15 comprising…”
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