Search Results - "Kadakia, Madhavi P"

ERK3 is transcriptionally upregulated by ∆Np63α and mediates the role of ∆Np63α in suppressing cell migration in non-melanoma skin cancers by Alshammari, Eid S, Aljagthmi, Amjad A, Stacy, Andrew J, Bottomley, Mike, Shamma, H Nicholas, Kadakia, Madhavi P, Long, Weiwen

“…p63, a member of the p53 gene family, is an important regulator for epithelial tissue growth and development. ∆Np63α is the main isoform of p63 and highly…”
Get full text

Pten Loss Induces Autocrine FGF Signaling to Promote Skin Tumorigenesis by Hertzler-Schaefer, Kristina, Mathew, Grinu, Somani, Ally-Khan, Tholpady, Sunil, Kadakia, Madhavi P., Chen, Yiping, Spandau, Dan F., Zhang, Xin

“…Inactivation of the Pten tumor suppressor negatively regulates the PI3K-mTOR pathway. In a model of cutaneous squamous cell carcinoma (SCC), we demonstrate…”
Get full text

Np63α inhibits Rac1 activation and cancer cell invasion through suppression of PREX1 by Aljagthmi, Amjad A., Hira, Akshay, Zhang, Jin, Cooke, Mariana, Kazanietz, Marcelo G., Kadakia, Madhavi P.

“…ΔNp63α, a member of the p53 family of transcription factors, plays a critical role in maintaining the proliferative potential of stem cells in the stratified…”
Get full text

Patterned Silk Films Cast from Ionic Liquid Solubilized Fibroin as Scaffolds for Cell Growth by Gupta, Maneesh K, Khokhar, Shama K, Phillips, David M, Sowards, Laura A, Drummy, Lawrence F, Kadakia, Madhavi P, Naik, Rajesh R

“…Silk is an attractive biomaterial for use in tissue engineering applications because of its slow degradation, excellent mechanical properties, and…”
Get full text

Differential MicroRNA Signatures in the Pathogenesis of Barrett's Esophagus by Craig, Michael P., Rajakaruna, Sumudu, Paliy, Oleg, Sajjad, Mumtaz, Madhavan, Srivats, Reddy, Nikhil, Zhang, Jin, Bottomley, Michael, Agrawal, Sangeeta, Kadakia, Madhavi P.

“…Barrett's esophagus (BE) is the precursor lesion and a major risk factor for esophageal adenocarcinoma (EAC). Although patients with BE undergo routine…”
Get full text

Role of vitamin D3 in modulation of ΔNp63α expression during UVB induced tumor formation in SKH-1 mice by Hill, Natasha T, Gracia-Maldonado, Gabriel H, Leonard, Mary K, Harper, Amanda R, Tober, Kathleen L, Oberyszyn, Tatiana M, Kadakia, Madhavi P

“…ΔNp63α, a proto-oncogene, is up-regulated in non-melanoma skin cancers and directly regulates the expression of both Vitamin D receptor (VDR) and phosphatase…”
Get full text

Serdemetan antagonizes the Mdm2-HIF1α axis leading to decreased levels of glycolytic enzymes by Lehman, Jason A, Hauck, Paula M, Gendron, Jaimie M, Batuello, Christopher N, Eitel, Jacob A, Albig, Allan, Kadakia, Madhavi P, Mayo, Lindsey D

“…Serdemetan (JNJ-26854165), an antagonist to Mdm2, was anticipated to promote the activation of p53. While regulation of p53 by Mdm2 is important, Mdm2 also…”
Get full text

Cellular internalization and targeting of semiconductor quantum dots by Rozenzhak, Sophie M, Kadakia, Madhavi P, Caserta, Tina M, Westbrook, Tiffany R, Stone, Morley O, Naik, Rajesh R

“…Peptide-mediated internalization and organelle targeting of quantum dots…”
Get more information

p63 Overexpression Induces the Expression of Sonic Hedgehog by Caserta, Tina M, Kommagani, Ramakrishna, Yuan, Ziqiang, Robbins, David J, Mercer, Carol A, Kadakia, Madhavi P

“…p63 and p73 are members of the p53 protein family and have been shown to play an important role in cell death, development, and tumorigenesis. In particular,…”
Get full text

CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor κB: implications for bidirectional tumor-stromal interactions by Singh, Ajay P, Arora, Sumit, Bhardwaj, Arun, Srivastava, Sanjeev K, Kadakia, Madhavi P, Wang, Bin, Grizzle, William E, Owen, Laurie B, Singh, Seema

“…Recent evidence suggests a major role of tumor-stromal interactions in pancreatic cancer pathobiology. The chemokine CXCL12 (stromal cell-derived factor 1…”
Get full text

Differential effects of p63 mutants on transactivation of p53 and/or p63 responsive genes by Khokhar, Shama K, Kommagani, Ramakrishna, Kadakia, Madhavi P

“…p63, known to play a role in development, has more recently also been implicated in cancer progression. Mutations in p63 have been shown to be responsible for…”
Get full text

TIP60 up-regulates ΔNp63α to promote cellular proliferation by Stacy, Andrew J., Zhang, Jin, Craig, Michael P., Hira, Akshay, Dole, Nikhil, Kadakia, Madhavi P.

“…An estimated 5.4 million cases of nonmelanoma skin cancer are reported in the United States at an associated cost of $4.8 billion. ΔNp63α, a proto-oncogene in…”
Get full text

Muscle-derived microRNAs correlated with thigh lean mass gains during progressive resistance training in older adults by O'Bryan, Samia M, Lavin, Kaleen M, Graham, Zachary A, Drummer, Devin J, Tuggle, S Craig, Van Keuren-Jensen, Kendall, Reiman, Rebecca, Alsop, Eric, Kadakia, Madhavi P, Craig, Michael P, Zhang, Jin, Bamman, Marcas M

“…Resistance training (RT) remains the most effective treatment for age-related declines in muscle mass. However, many older adults experience attenuated muscle…”
Get full text

In Operando Observation of Neuropeptide Capture and Release on Graphene Field-Effect Transistor Biosensors with Picomolar Sensitivity by Kim, Steve, Xing, Li, Islam, Ahmad E, Hsiao, Ming-Siao, Ngo, Yen, Pavlyuk, Oksana M, Martineau, Rhett L, Hampton, Cheri M, Crasto, Cameron, Slocik, Joseph, Kadakia, Madhavi P, Hagen, Joshua A, Kelley-Loughnane, Nancy, Naik, Rajesh R, Drummy, Lawrence F

“…Transmission electron microscopy (TEM) is being pushed to new capabilities which enable studies on systems that were previously out of reach. Among recent…”
Get full text

ΔNp63α suppresses cells invasion by downregulating PKCγ/Rac1 signaling through miR-320a by Aljagthmi, Amjad A., Hill, Natasha T., Cooke, Mariana, Kazanietz, Marcelo G., Abba, Martín C., Long, Weiwen, Kadakia, Madhavi P.

“…ΔNp63α, a member of the p53 family of transcription factors, is overexpressed in a number of cancers and plays a role in proliferation, differentiation,…”
Get full text

Clay enriched silk biomaterials for bone formation by Mieszawska, Aneta J., Llamas, Jabier Gallego, Vaiana, Christopher A., Kadakia, Madhavi P., Naik, Rajesh R., Kaplan, David L.

“…The formation of silk protein/clay composite biomaterials for bone tissue formation is described. Silk fibroin serves as an organic scaffolding material…”
Get full text

Identification of novel ΔNp63α-regulated miRNAs using an optimized small RNA-Seq analysis pipeline by Sakaram, Suraj, Craig, Michael P., Hill, Natasha T., Aljagthmi, Amjad, Garrido, Christian, Paliy, Oleg, Bottomley, Michael, Raymer, Michael, Kadakia, Madhavi P.

“…Advances in high-throughput sequencing have enabled profiling of microRNAs (miRNAs), however, a consensus pipeline for sequencing of small RNAs has not been…”
Get full text

Differential Regulation of Vitamin D Receptor (VDR) by the p53 Family: p73-DEPENDENT INDUCTION OF VDR UPON DNA DAMAGE by Kommagani, Ramakrishna, Payal, Vandana, Kadakia, Madhavi P

“…p63 and p73, members of the p53 family, have been shown to be functionally distinct from p53. Vitamin D receptor (VDR) is a ligand (vitamin D₃)-dependent…”
Get full text

Inverse associations between cardiometabolic risk factors and 25-hydroxyvitamin D in obese American children and adolescents by Lee, Miryoung, Ebert, James R., Kadakia, Madhavi P., Zhang, Jin, Czerwinski, Stefan A.

“…Objectives To examine the association between 25‐hydroxyvitamin D [25(OH)D] concentrations and cardiometabolic risk factors in obese American children. Methods…”
Get full text

The PTEN-Akt pathway impacts the integrity and composition of mitotic centrosomes by Leonard, Mary, Hill, Natasha, Bubulya, Paula, Kadakia, Madhavi

“…Loss of the tumor suppressor PTEN is observed in many human cancers that display increased chromosome instability and aneuploidy. The subcellular fractions of…”
Get full text