Search Results - "Kad, Neil M"

The TFIIH subunits p44/p62 act as a damage sensor during nucleotide excision repair by Barnett, Jamie T, Kuper, Jochen, Koelmel, Wolfgang, Kisker, Caroline, Kad, Neil M

“…Abstract Nucleotide excision repair (NER) in eukaryotes is orchestrated by the core form of the general transcription factor TFIIH, containing the helicases…”
Get full text

Selective antagonism of cJun for cancer therapy by Brennan, Andrew, Leech, James T, Kad, Neil M, Mason, Jody M

“…The activator protein-1 (AP-1) family of transcription factors modulate a diverse range of cellular signalling pathways into outputs which can be oncogenic or…”
Get full text

Developing novel antimicrobials by combining cancer chemotherapeutics with bacterial DNA repair inhibitors by Bernacchia, Lorenzo, Gupta, Arya, Paris, Antoine, Moores, Alexandra A, Kad, Neil M

“…Cancer chemotherapeutics kill rapidly dividing cells, which includes cells of the immune system. The resulting neutropenia predisposes patients to infection,…”
Get full text

Single-Molecule Imaging Reveals that Rad4 Employs a Dynamic DNA Damage Recognition Process by Kong, Muwen, Liu, Lili, Chen, Xuejing, Driscoll, Katherine I., Mao, Peng, Böhm, Stefanie, Kad, Neil M., Watkins, Simon C., Bernstein, Kara A., Wyrick, John J., Min, Jung-Hyun, Van Houten, Bennett

“…Nucleotide excision repair (NER) is an evolutionarily conserved mechanism that processes helix-destabilizing and/or -distorting DNA lesions, such as…”
Get full text

Identification of the target and mode of action for the prokaryotic nucleotide excision repair inhibitor ATBC by Bernacchia, Lorenzo, Paris, Antoine, Gupta, Arya, Moores, Alexandra A, Kad, Neil M

“…In bacteria, nucleotide excision repair (NER) plays a major role in repairing DNA damage from a wide variety of sources. Therefore, its inhibition offers…”
Get full text

Collaborative Dynamic DNA Scanning by Nucleotide Excision Repair Proteins Investigated by Single- Molecule Imaging of Quantum-Dot-Labeled Proteins by Kad, Neil M., Wang, Hong, Kennedy, Guy G., Warshaw, David M., Van Houten, Bennett

“…How DNA repair proteins sort through a genome for damage is one of the fundamental unanswered questions in this field. To address this problem, we uniquely…”
Get full text

Direct Measurements of Local Coupling between Myosin Molecules Are Consistent with a Model of Muscle Activation by Walcott, Sam, Kad, Neil M

“…Muscle contracts due to ATP-dependent interactions of myosin motors with thin filaments composed of the proteins actin, troponin, and tropomyosin. Contraction…”
Get full text

TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres by Lin, Jiangguo, Countryman, Preston, Buncher, Noah, Kaur, Parminder, E, Longjiang, Zhang, Yiyun, Gibson, Greg, You, Changjiang, Watkins, Simon C, Piehler, Jacob, Opresko, Patricia L, Kad, Neil M, Wang, Hong

“…Human telomeres are maintained by the shelterin protein complex in which TRF1 and TRF2 bind directly to duplex telomeric DNA. How these proteins find telomeric…”
Get full text

Intracellular selection of peptide inhibitors that target disulphide‐bridged Aβ42 oligomers by Acerra, Nicola, Kad, Neil. M., Cheruvara, Harish, Mason, Jody M.

“…The β‐amyloid (Aβ) peptide aggregates into a number of soluble and insoluble forms, with soluble oligomers thought to be the primary factor implicated in…”
Get full text

Single-molecule imaging reveals the concerted release of myosin from regulated thin filaments by Smith, Quentin M, Inchingolo, Alessio V, Mihailescu, Madalina-Daniela, Dai, Hongsheng, Kad, Neil M

“…Regulated thin filaments (RTFs) tightly control striated muscle contraction through calcium binding to troponin, which enables tropomyosin to expose…”
Get full text

Load and Pi Control Flux through the Branched Kinetic Cycle of Myosin V by Kad, Neil M., Trybus, Kathleen M., Warshaw, David M.

“…Myosin V is a processive actin-based motor protein that takes multiple 36-nm steps to deliver intracellular cargo to its destination. In the laser trap,…”
Get full text

DNA-Protein Interactions Studied Directly Using Single Molecule Fluorescence Imaging of Quantum Dot Tagged Proteins Moving on DNA Tightropes by Springall, Luke, Inchingolo, Alessio V, Kad, Neil M

“…Many protein interactions with DNA require specific sequences; however, how these sequences are located remains uncertain. DNA normally appears bundled in…”
Get more information

A Branched Kinetic Scheme Describes the Mechanochemical Coupling of Myosin Va Processivity in Response to Substrate by Zhang, Chong, Yusuf Ali, M., Warshaw, David M., Kad, Neil M.

“…Myosin Va is a double-headed cargo-carrying molecular motor that moves processively along cellular actin filaments. Long processive runs are achieved through…”
Get full text

Single Qdot-labeled glycosylase molecules use a wedge amino acid to probe for lesions while scanning along DNA by Dunn, Andrew R., Kad, Neil M., Nelson, Shane R., Warshaw, David M., Wallace, Susan S.

Get full text

Single-Myosin Crossbridge Interactions with Actin Filaments Regulated by Troponin-Tropomyosin by Kad, Neil M., Kim, Scott, Warshaw, David M., VanBuren, Peter, Baker, Josh E.

“…Striated muscle contraction is governed by the thin filament regulatory proteins troponin and tropomyosin. Here, we investigate the molecular mechanisms by…”
Get full text

Single molecule iSCAT imaging reveals a fast, energy efficient search mode for the DNA repair protein UvrA by Charman, Robert J, Kad, Neil M

“…Exposure to UV radiation results in numerous DNA lesions, which threaten genome integrity. The nucleotide excision DNA repair pathway detects and repairs a…”
Get more information

Real-time single-molecule imaging reveals a direct interaction between UvrC and UvrB on DNA tightropes by Hughes, Craig D., Wang, Hong, Ghodke, Harshad, Simons, Michelle, Towheed, Atif, Peng, Ye, Van Houten, Bennett, Kad, Neil M.

Get full text

Revealing the mechanism of how cardiac myosin-binding protein C N-terminal fragments sensitize thin filaments for myosin binding by Inchingolo, Alessio V, Previs, Samantha Beck, Previs, Michael J, Warshaw, David M, Kad, Neil M

“…Cardiac muscle contraction is triggered by calcium binding to troponin. The consequent movement of tropomyosin permits myosin binding to actin, generating…”
Get full text

Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE) by Schaich, Matthew A, Schnable, Brittani L, Kumar, Namrata, Roginskaya, Vera, Jakielski, Rachel C, Urban, Roman, Zhong, Zhou, Kad, Neil M, Van Houten, Bennett

“…Abstract Single-molecule characterization of protein–DNA dynamics provides unprecedented mechanistic details about numerous nuclear processes. Here, we…”
Get full text

Using Fluorescent Myosin to Directly Visualize Cooperative Activation of Thin Filaments by Desai, Rama, Geeves, Michael A., Kad, Neil M.

“…Contraction of striated muscle is tightly regulated by the release and sequestration of calcium within myocytes. At the molecular level, calcium modulates…”
Get full text