Search Results - "Kaczorowski, G. J"

Potassium channels: from scorpion venoms to high-resolution structure by Garcia, M.L, Gao, Ying-Duo, McManus, O.B, Kaczorowski, G.J

“…In 1998, the field of ion channel research entered a new era when the first, high-resolution crystal structure of one of these proteins was solved. The protein…”
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Developing Molecular Pharmacology of BK Channels for Therapeutic Benefit by Kaczorowski, G J, Garcia, M L

“…High conductance, calcium-activated potassium (BK) channels (KCa1.1) are important in regulating physiologic responses in many types of tissues and, as such,…”
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Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels by Garcia-Calvo, M., Leonard, R.J., Novick, J., Stevens, S.P., Schmalhofer, W., Kaczorowski, G.J., Garcia, M.L.

“…A novel peptidyl inhibitor of K+ channels has been purified to homogeneity from venom of the new world scorpion Centruroides margaritatus. The primary…”
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Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus by GALVEZ, A, GIMENEZ-GALLEGO, G, REUBEN, J. P, ROY-CONTANCIN, L, FEIGENBAUM, P, KACZOROWSKI, G. J, GARCIA, M. L

“…An inhibitor of the high conductance, Ca2(+)-activated K+ channel (PK,Ca) has been purified to homogeneity from venom of the scorpion Buthus tamulus by a…”
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Subunit composition of the high conductance calcium-activated potassium channel from smooth muscle, a representative of the mSlo and slowpoke family of potassium channels by KNAUS, H.-G, GARCIA-CALVO, M, KACZOROWSKI, G. J, GARCIA, M. L

“…High conductance Ca(2+)-activated K+ (maxi-K) channels from bovine tracheal and aortic smooth muscle membranes have been purified employing monoiodotyrosine…”
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Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter release by Robitaille, R, Garcia, M L, Kaczorowski, G J, Charlton, M P

“…We examined, using physiological and morphological techniques, the distribution of Ca(2+)-gated K+ (gKca) channels relative to the location of Ca2+ channels…”
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Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: targeting to axons and nerve terminals by Knaus, HG, Schwarzer, C, Koch, RO, Eberhart, A, Kaczorowski, GJ, Glossmann, H, Wunder, F, Pongs, O, Garcia, ML, Sperk, G

“…Tissue expression and distribution of the high-conductance Ca(2+)-activated K+ channel Slo was investigated in rat brain by immunocytochemistry, in situ…”
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An activator of calcium-dependent potassium channels isolated from a medicinal herb by McManus, O. B, Harris, G. H, Giangiacomo, K. M, Feigenbaum, P, Reuben, J. P, Addy, M. E, Burka, J. F, Kaczorowski, G. J, Garcia, M. L

“…Large-conductance calcium-dependent potassium (maxi-K) channels play an important role in regulating the tone of airway smooth muscle and the release of…”
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Charybdotoxin and its effects on potassium channels by Garcia, M L, Knaus, H G, Munujos, P, Slaughter, R S, Kaczorowski, G J

“…Over the last few years, a considerable amount of information has been obtained regarding K+ channels. Different areas of research have contributed to…”
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Molecular analysis of two cytochrome P450 monooxygenase genes required for paxilline biosynthesis in Penicillium paxilli, and effects of paxilline intermediates on mammalian maxi-K ion channels by McMillan, L K, Carr, R L, Young, C A, Astin, J W, Lowe, R G T, Parker, E J, Jameson, G B, Finch, S C, Miles, C O, McManus, O B, Schmalhofer, W A, Garcia, M L, Kaczorowski, G J, Goetz, M, Tkacz, J S, Scott, B

“…The gene cluster required for paxilline biosynthesis in Penicillium paxilli contains two cytochrome P450 monooxygenase genes, paxP and paxQ. The primary…”
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Purification and reconstitution of the high-conductance, calcium-activated potassium channel from tracheal smooth muscle by GARCIA-CALVO, M, KNAUS, H.-G, MCMANUS, O. B, GIANGIACOMO, K. M, KACZOROWSKI, G. J, GARCIA, M. L

“…The high-conductance Ca(2+)-activated K+ (maxi-K) channel from bovine tracheal smooth muscle was purified to apparent homogeneity by a combination of…”
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Selective inhibition of relaxation of guinea-pig trachea by charybdotoxin, a potent Ca(++)-activated K+ channel inhibitor by Jones, T R, Charette, L, Garcia, M L, Kaczorowski, G J

“…Airway smooth muscle plasma membranes are rich in K+ channels of various types. Charybdotoxin (ChTX) is a potent blocker of the high-conductance…”
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Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle by Winquist, R J, Heaney, L A, Wallace, A A, Baskin, E P, Stein, R B, Garcia, M L, Kaczorowski, G J

“…BRL 34915 [6-cyano-3,4-dihydro-2,2-dimethyl-trans-4-(2-oxo-1-pyrrolidyl) 2H-benzo(b) pyran-3-ol], minoxidil sulfate and diazoxide may relax vascular smooth…”
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Purification, Sequence, and Model Structure of Charybdotoxin, a Potent Selective Inhibitor of Calcium-Activated Potassium Channels by Gimenez-Gallego, Guillermo, Navia, Manuel A., Reuben, John P., Katz, George M., Kaczorowski, Gregory J., Garcia, Maria L.

“…Charybdotoxin (ChTX), a protein present in the venom of the scorpion Leiurus quinquestriatus var. hebraeus, has been purified to homogeneity by a combination…”
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The beta subunit of the high conductance calcium-activated potassium channel. Identification of residues involved in charybdotoxin binding by Hanner, M, Vianna-Jorge, R, Kamassah, A, Schmalhofer, W A, Knaus, H G, Kaczorowski, G J, Garcia, M L

“…Coexpression of alpha and beta subunits of the high conductance Ca2+-activated K+ (maxi-K) channel leads to a 50-fold increase in the affinity for…”
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Effects of charybdotoxin and iberiotoxin on the spontaneous motility and tonus of different guinea pig smooth muscle tissues by Suarez-Kurtz, G, Garcia, M L, Kaczorowski, G J

“…Charybdotoxin (ChTX) and iberiotoxin (IbTX), two potent peptidyl blockers of the high conductance Ca(2+)-activated K+ channel (PK,Ca) were used to probe the…”
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Interaction of tetrandrine with slowly inactivating calcium channels. Characterization of calcium channel modulation by an alkaloid of Chinese medicinal herb origin by King, V F, Garcia, M L, Himmel, D, Reuben, J P, Lam, Y K, Pan, J X, Han, G Q, Kaczorowski, G J

“…Tetrandrine, a bis-benzylisoquinoline alkaloid derived from the Chinese medicinal herb Stephania tetrandra, is a putative Ca2+ entry blocker whose mechanism of…”
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Amiloride analogs inhibit L-type calcium channels and display calcium entry blocker activity by GARCIA, M. L, KING, V. F, SHEVELL, J. L, SLAUGHTER, R. S, SUAREZ-KURTZ, G, WINQUIST, R. J, KACZOROWSKI, G. J

“…Three structural classes of commonly used amiloride analogs, molecules derivatized at the terminal guanidino-nitrogen, the five-position pyrazinoyl-nitrogen,…”
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Interaction of iberiotoxin with beta-adrenoceptor agonists and sodium nitroprusside on guinea pig trachea by Jones, T R, Charette, L, Garcia, M L, Kaczorowski, G J

“…Airway smooth muscle plasma membranes contain a variety of functional K+ channels. In particular, there is a predominance of Ca(2+)-activated K+ channels…”
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Characterization of high affinity binding sites for charybdotoxin in synaptic plasma membranes from rat brain. Evidence for a direct association with an inactivating, voltage-dependent, potassium channel by VASQUEZ, J, FEIGENBAUM, P, KING, V. F, KACZOROWSKI, G. J, GARCIA, M. L

“…Charybdotoxin (ChTX), a potent peptidyl inhibitor of several types of K+ channels, binds to sites in vascular smooth muscle sarcolemma (Vázquez, J.,…”
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