Search Results - "Kacer, Doreen"

Notch signaling modulates hypoxia-induced neuroendocrine differentiation of human prostate cancer cells by Danza, Giovanna, Di Serio, Claudia, Rosati, Fabiana, Lonetto, Giuseppe, Sturli, Niccolò, Kacer, Doreen, Pennella, Antonio, Ventimiglia, Giuseppina, Barucci, Riccardo, Piscazzi, Annamaria, Prudovsky, Igor, Landriscina, Matteo, Marchionni, Niccolò, Tarantini, Francesca

“…Prostate carcinoma is among the most common causes of cancer-related death in men, representing 15% of all male malignancies in developed countries…”
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AHNAK2 Participates in the Stress-Induced Nonclassical FGF1 Secretion Pathway by Kirov, Aleksandr, Kacer, Doreen, Conley, Barbara A., Vary, Calvin P.H., Prudovsky, Igor

“…ABSTRACT FGF1 is a nonclassically released growth factor that regulates carcinogenesis, angiogenesis, and inflammation. In vitro and in vivo, FGF1 export is…”
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Regulation of non-classical FGF1 release and FGF-dependent cell transformation by CBF1-mediated notch signaling by Kacer, Doreen, McIntire, Christian, Kirov, Alek, Kany, Erin, Roth, Jennifer, Liaw, Lucy, Small, Deena, Friesel, Robert, Basilico, Claudio, Tarantini, Francesca, Verdi, Joseph, Prudovsky, Igor

“…FGF1, a widely expressed proangiogenic factor involved in tissue repair and carcinogenesis, is released from cells through a non‐classical pathway independent…”
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Soluble Jagged 1 Represses the Function of Its Transmembrane Form to Induce the Formation of the Src-dependent Chord-like Phenotype by Small, D, Kovalenko, D, Kacer, D, Liaw, L, Landriscina, M, Di Serio, C, Prudovsky, I, Maciag, T

“…We have previously demonstrated that the expression of the soluble extracellular domain of the transmembrane ligand for Notch receptors, Jagged 1 (sJ1), in NIH…”
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The intracellular domain of Notch ligand Delta1 induces cell growth arrest by Kolev, Vihren, Kacer, Doreen, Trifonova, Radiana, Small, Deena, Duarte, Maria, Soldi, Raffaella, Graziani, Irene, Sideleva, Olga, Larman, Barry, Maciag, Thomas, Prudovsky, Igor

“…Notch signaling involves proteolytic cleavage of the transmembrane Notch receptor after binding to its transmembrane ligands, Delta or Jagged; and the…”
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Notch Activation Suppresses Fibroblast Growth Factor-dependent Cellular Transformation by Small, Deena, Kovalenko, Dmitry, Soldi, Raffaella, Mandinova, Anna, Kolev, Vihren, Trifonova, Radiana, Bagala, Cinzia, Kacer, Doreen, Battelli, Chiara, Liaw, Lucy, Prudovsky, Igor, Maciag, Thomas

“…Aberrant activations of the Notch and fibroblast growth factor receptor (FGFR) signaling pathways have been correlated with neoplastic growth in humans and…”
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The Non-transmembrane Form of Delta1, but Not of Jagged1, Induces Normal Migratory Behavior Accompanied by Fibroblast Growth Factor Receptor 1-dependent Transformation by Trifonova, Radiana, Small, Deena, Kacer, Doreen, Kovalenko, Dmitry, Kolev, Vihren, Mandinova, Anna, Soldi, Raffaella, Liaw, Lucy, Prudovsky, Igor, Maciag, Thomas

“…The interactions between Notch (N) receptors and their transmembrane ligands, Jagged1 (JI) and Delta1 (Dl1), mediate signaling events between neighboring cells…”
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Tranexamic acid: Beyond antifibrinolysis by Prudovsky, Igor, Kacer, Doreen, Zucco, Victoria Vieira, Palmeri, Monica, Falank, Carolyne, Kramer, Robert, Carter, Damien, Rappold, Joseph

“…Tranexamic acid (TXA) is a popular antifibrinolytic drug widely used in hemorrhagic trauma patients and cardiovascular, orthopedic, and gynecological surgical…”
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75 Tranexamic Acid Reduces Burn Wound Conversion and Lung Inflammation in a Murine Comb Burn Model by Carter, Damien, Kacer, Doreen, Turner, Elizabeth, Prudovsky, Igor

“…Abstract Introduction Burn wound conversion is a process where superficial partial thickness burns convert into deep partial and even full thickness burn…”
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Anti‐fibrinolytic agent tranexamic acid suppresses the endotoxin‐induced expression of Tnfα and Il1α genes in a plasmin‐independent manner by Kacer, Doreen, Machnitzky, Eva, Fung, Angus, Greene, Autumn, Carter, Damien, Rappold, Joseph, Prudovsky, Igor

“…Introduction Tranexamic acid (TXA) is widely used as an antifibrinolytic agent in hemorrhagic trauma patients. The beneficial effects of TXA exceed the…”
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Tranexamic acid reduces inflammation, edema and burn wound conversion in a rodent model by Prudovsky, Igor, Kacer, Doreen, Lindner, Volkhard, Rappold, Joseph, Carter, Damien Wilson

“…Burn wound conversion is the observed process where superficial partial thickness burns convert into deep partial or full thickness burn injuries. This…”
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Endoglin Controls Cell Migration and Composition of Focal Adhesions by Conley, Barbara A., Koleva, Rositsa, Smith, Joshua D., Kacer, Doreen, Zhang, Dongwang, Bernabéu, Carmelo, Vary, Calvin P.H.

“…Mutations in the human endoglin gene result in hereditary hemorrhagic telangiectasia type 1, a vascular disorder characterized by multisystemic vascular…”
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Tranexamic acid suppresses the release of mitochondrial DAMPs and reduces lung inflammation in a murine burn model by Carter, Damien Wilson, Prudovsky, Igor, Kacer, Doreen, Soul, Tee, Kumpel, Chloe, Pyburn, Kathleen, Palmeri, Monica, Kramer, Robert, Rappold, Joseph

“…Severe burn injuries are known to initiate a profound systemic inflammatory response (SIRS) that may lead to burn shock and other SIRS-related complications…”
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Tranexamic acid suppresses the release of mitochondrial DNA, protects the endothelial monolayer and enhances oxidative phosphorylation by Prudovsky, Igor, Carter, Damien, Kacer, Doreen, Palmeri, Monica, Soul, Tee, Kumpel, Chloe, Pyburn, Kathleen, Barrett, Karyn, DeMambro, Victoria, Alexandrov, Ilya, Brandina, Irina, Kramer, Robert, Rappold, Joseph

“…Damage‐associated molecular patterns, including mitochondrial DNA (mtDNA) are released during hemorrhage resulting in the development of endotheliopathy…”
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Sustained Inhibition of Proliferative Response After Transient FGF Stimulation Is Mediated by Interleukin 1 Signaling by Poole, Ashleigh, Kacer, Doreen, Cooper, Emily, Tarantini, Francesca, Prudovsky, Igor

“…Transient FGF stimulation of various cell types results in FGF memory—a sustained blockage of efficient proliferative response to FGF and other growth factors…”
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Activated CTHRC1 promotes glycolysis in endothelial cells: Implications for metabolism and angiogenesis by Toomey, Barbara H., Mitrovic, Sarah A., Lindner-Liaw, Maia, Leon Vazquez, Ruth G., Kacer, Doreen, Ryzhov, Sergey, Prudovsky, Igor, Lindner, Volkhard

“…CTHRC1 is transiently expressed by activated fibroblasts during tissue repair and in certain cancers, and CTHRC1 derived from osteocytes is detectable in…”
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Induction of endogenous interleukin 1 alpha limits to one cycle the proliferative response to FGF by Prudovsky, Igor, Poole, Ashleigh, Cooper, Emily, Kacer, Doreen

“…Abstract only We found that transient FGF stimulation of various cell types results in the novel phenomenon termed “FGF memory” – a sustained blockage of…”
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Prolonged Cardiopulmonary Bypass is Associated With Endothelial Glycocalyx Degradation by Robich, Michael, Ryzhov, Sergey, Kacer, Doreen, Palmeri, Monica, Peterson, Sarah M., Quinn, Reed D., Carter, Damien, Sheppard, Forest, Hayes, Timothy, Sawyer, Douglas B., Rappold, Joseph, Prudovsky, Igor, Kramer, Robert S.

“…The endothelial glycocalyx (EG) is involved in critical regulatory mechanisms that maintain endothelial vascular integrity. We hypothesized that prolonged…”
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Mesoderm‐specific transcript localization in the ER and ER‐lipid droplet interface supports a role in adipocyte hypertrophy by Prudovsky, Igor, Anunciado‐Koza, Rea P., Jacobs, Chester G., Kacer, Doreen, Siviski, Matthew E., Koza, Robert A.

“…Highly variable expression of mesoderm‐specific transcript (Mest) in adipose tissue among genetically homogeneous mice fed an obesogenic diet, and its positive…”
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Cthrc1 controls adipose tissue formation, body composition, and physical activity by Stohn, J. Patrizia, Wang, Qiaozeng, Siviski, Matthew E., Kennedy, Kevin, Jin, Yong‐Ri, Kacer, Doreen, DeMambro, Victoria, Liaw, Lucy, Vary, Calvin P., Rosen, Clifford J., Prudovsky, Igor, Lindner, Volkhard

“…Objective This study investigated the effects of loss of Cthrc1 on adipogenesis, body composition, metabolism, physical activity, and muscle physiology…”
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