Search Results - "Kabra, Ashish"

Unveiling the Druggable Landscape of Bacterial Peptidyl tRNA Hydrolase: Insights into Structure, Function, and Therapeutic Potential by Mundra, Surbhi, Kabra, Ashish

“…Bacterial peptidyl tRNA hydrolase (Pth) or Pth1 emerges as a pivotal enzyme involved in the maintenance of cellular homeostasis by catalyzing the release of…”
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Observation of Arginine Side-Chain Motions Coupled to the Global Conformational Exchange Process in Deubiquitinase A by Kabra, Ashish, Rumpa, Efsita, Li, Ying

“…Coupled motions have been demonstrated to be functionally important in a number of enzymes. Noncovalent side-chain interactions play essential roles in…”
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Unraveling the stereochemical and dynamic aspects of the catalytic site of bacterial peptidyl-tRNA hydrolase by Kabra, Ashish, Shahid, Salman, Pal, Ravi Kant, Yadav, Rahul, Pulavarti, S V S Rama Krishna, Jain, Anupam, Tripathi, Sarita, Arora, Ashish

“…Bacterial peptidyl-tRNA hydrolase (Pth; EC 3.1.1.29) hydrolyzes the peptidyl-tRNAs accumulated in the cytoplasm and thereby prevents cell death by alleviating…”
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THE USE OF CAROTID INTIMAL MEDIA THICKNESS IN THE PREDICTION OF STEMI by Kabra, Ashish N, Matsumura, Martin, Neri, Lori, Roberts, Justin

“…Background Patients who present with ST elevation myocardial infarction (STEMI) typically have fewer traditional risk factors vs. patients with other forms of…”
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Structural characterization of peptidyl-tRNA hydrolase from Mycobacterium smegmatis by NMR spectroscopy by Kabra, Ashish, Fatma, Farheen, Shahid, Salman, Pathak, Prem Prakash, Yadav, Rahul, Pulavarti, S.V.S.R. Krishna, Tripathi, Sarita, Jain, Anupam, Arora, Ashish

“…Accumulation of toxic peptidyl-tRNAs in the bacterial cytoplasm is averted by the action of peptidyl-tRNA hydrolase (Pth), which cleaves peptidyl-tRNA into…”
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The Intrinsically Disordered Proteins MLLT3 (AF9) and MLLT1 (ENL) – Multimodal Transcriptional Switches With Roles in Normal Hematopoiesis, MLL Fusion Leukemia, and Kidney Cancer by Kabra, Ashish, Bushweller, John

“…[Display omitted] •MLLT3 and MLLT1 drive protein-protein interactions via coupled binding and folding.•Fusion proteins (MLL-AF9 and MLL-ENL) with MLL are…”
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Bike-Share Systems: Accessibility and Availability by Kabra, Ashish, Belavina, Elena, Girotra, Karan

“…The cities of Paris, London, Chicago, and New York (among many others) have set up bike-share systems to facilitate the use of bicycles for urban commuting…”
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Conformational Dynamics of Deubiquitinase A and Functional Implications by Kabra, Ashish, Li, Ying

“…Deubiquitinase A (DUBA) belongs to the ovarian tumor family of deubiquitinating enzymes and was initially identified as a negative regulator of type I…”
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Online Grocery Retail: Revenue Models and Environmental Impact by Belavina, Elena, Girotra, Karan, Kabra, Ashish

“…This paper compares the financial and environmental performance of two revenue models for the online retailing of groceries: the per-order model, where…”
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Functional Dynamics of Deubiquitinase A by Li, Ying, Fether, Skyler, Kabra, Ashish

“…Deubiquitinase A (DUBA) is an isopeptidase that cleaves K63‐linked and K48‐linked ubiquitin chains from substrate proteins. DUBA belongs to the ovarian tumor…”
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Abstract 1995: Functional Roles of Conformational Dynamics in Deubiquitinating Enzymes by Li, Ying, Lundy, Seth, Fether, Skyler, Kabra, Ashish

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Modulation of conformational equilibrium by phosphorylation underlies the activation of deubiquitinase A by Kabra, Ashish, Rumpa, Efsita, Li, Ying

“…Deubiquitinases deconjugate ubiquitin modifications from target proteins and are involved in many cellular processes in eukaryotes. The functions of…”
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Recombinant expression and purification of human EP300-KIX87 domain from Escherichia coli by Bushweller, John H., Park, Kwon-Sik, Kabra, Ashish

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Role of methionine 71 in substrate recognition and structural integrity of bacterial peptidyl-tRNA hydrolase by Shahid, Salman, Kabra, Ashish, Mundra, Surbhi, Pal, Ravi Kant, Tripathi, Sarita, Jain, Anupam, Arora, Ashish

“…Bacterial peptidyl-tRNA hydrolase (Pth) is an essential enzyme that alleviates tRNA starvation by recycling prematurely dissociated peptidyl-tRNAs. The…”
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Small-Molecule Inhibitors of the MLL1 CXXC Domain, an Epigenetic Reader of DNA Methylation by Kalmode, Hanuman P., Podsiadly, Izabella, Kabra, Ashish, Boulton, Adam, Reddy, Prabhakar, Gao, Yan, Li, Christopher, Bushweller, John H.

“…The CXXC domain is a reader of DNA methylation which preferentially binds to unmethylated CpG DNA motifs. Chromosomal translocations involving the MLL1 gene…”
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Backbone 1 H, 13 C, and 15 N resonance assignments of deubiquitinase A in non-phosphorylated and phosphorylated forms by Kabra, Ashish, Benson, Catherine A, Li, Ying

“…Ubiquitination is one of the most prevalent forms of post-translational modifications that are important for regulating many cellular processes in eukaryotes…”
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Essays on New Business Models in Smart Transportation and Deli by Kabra, Ashish

“…The public and private sector are developing technology enabled disruptive business models for transportation and delivery. They aim to address growing…”
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Backbone 1H, 13C, and 15N resonance assignments of deubiquitinase A in non-phosphorylated and phosphorylated forms by Kabra, Ashish, Benson, Catherine A., Li, Ying

“…Ubiquitination is one of the most prevalent forms of post-translational modifications that are important for regulating many cellular processes in eukaryotes…”
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Solution structures and dynamics of ADF/cofilins UNC-60A and UNC-60B from Caenorhabditis elegans by Shukla, Vaibhav Kumar, Kabra, Ashish, Maheshwari, Diva, Yadav, Rahul, Jain, Anupam, Tripathi, Sarita, Ono, Shoichiro, Kumar, Dinesh, Arora, Ashish

“…The nematode Caenorhabditis elegans has two ADF (actin-depolymerizing factor)/cofilin isoforms, UNC-60A and UNC-60B, which are expressed by the unc60 gene by…”
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KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer by Kim, Kee-Beom, Kabra, Ashish, Kim, Dong-Wook, Xue, Yongming, Huang, Yuanjian, Hou, Pei-Chi, Zhou, Yunpeng, Miranda, Leilani J, Park, Jae-Il, Shi, Xiaobing, Bender, Timothy P, Bushweller, John H, Park, Kwon-Sik

“…EP300, a transcription coactivator important in proliferation and differentiation, is frequently mutated in diverse cancer types, including small cell lung…”
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