Search Results - "Kabouridis, Panagiotis S."

Microbiota controls the homeostasis of glial cells in the gut lamina propria by Kabouridis, Panagiotis S, Lasrado, Reena, McCallum, Sarah, Chng, Song Hui, Snippert, Hugo J, Clevers, Hans, Pettersson, Sven, Pachnis, Vassilis

“…The intrinsic neural networks of the gastrointestinal tract are derived from dedicated neural crest progenitors that colonize the gut during embryogenesis and…”
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Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system by Kabouridis, Panagiotis S, Pachnis, Vassilis

“…The enteric nervous system (ENS) consists of neurons and glial cells that differentiate from neural crest progenitors. During embryogenesis, development of the…”
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Biological applications of protein transduction technology by Kabouridis, Panagiotis S

“…The impermeable nature of the cell membrane to peptides, proteins, DNA and oligonucleotides limits the therapeutic potential of these biological agents…”
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Lipid rafts in T cell receptor signalling by Kabouridis, Panagiotis S

“…The molecular events and the protein components that are involved in signalling by the T cell receptor (TCR) for antigen have been extensively studied…”
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Lipid rafts and T-lymphocyte function: Implications for autoimmunity by Kabouridis, Panagiotis S., Jury, Elizabeth C.

“…Experimental evidence indicates that the mammalian cell membrane is compartmentalized. A structural feature that supports membrane segmentation implicates…”
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Lipid rafts in T cell signalling and disease by Jury, Elizabeth C., Flores-Borja, Fabian, Kabouridis, Panagiotis S.

“…Lipid rafts is a blanket term used to describe distinct areas in the plasma membrane rich in certain lipids and proteins and which are thought to perform…”
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The gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune system by Kabouridis, Panagiotis S, Lasrado, Reena, McCallum, Sarah, Chng, Song Hui, Snippert, Hugo J, Clevers, Hans, Pettersson, Sven, Pachnis, Vassilis

“…The enteric nervous system (ENS) coordinates the major functions of the gastrointestinal tract. Its development takes place within a constantly changing…”
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Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus by Jury, Elizabeth C, Kabouridis, Panagiotis S, Flores-Borja, Fabian, Mageed, Rizgar A, Isenberg, David A

“…Systemic lupus erythematosus (SLE) is characterized by abnormalities in T lymphocyte receptor-mediated signal transduction pathways. Our previous studies have…”
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Secretion and uptake of TAT-fusion proteins produced by engineered mammalian cells by Koutsokeras, Apostolos, Kabouridis, Panagiotis S.

“…Intracellular signaling can be regulated by the exogenous addition of physiological protein inhibitors coupled to the TAT protein transduction domain. Thus far…”
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Distinct localization of T cell Agrin during antigen presentation – evidence for the expression of Agrin receptor(s) in antigen‐presenting cells by Kabouridis, Panagiotis S., Pimentel, Tatiana A., Brancaleone, Vincenzo, D’Acquisto, Fulvio, Oliani, Sonia M., Perretti, Mauro, Jury, Elizabeth C.

“…Agrin is over‐expressed by activated and autoimmune T cells, and synergizes with the T cell receptor (TCR) to augment cell activation. In the present study, we…”
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A negatively charged domain of LAT mediates its interaction with the active form of Lck by Kabouridis, Panagiotis S, Isenberg, David A, Jury, Elizabeth C

“…We have shown previously that in T cells, LAT co-immunoprecipitates with the active but not the inactive-'closed' form of Lck, and that this interaction…”
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Selective interaction of LAT (linker of activated T cells) with the open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells by Kabouridis, Panagiotis S

“…In T cells, the lipid raft-associated Lck is strongly tyrosine phosphorylated and has reduced enzymic activity in contrast with the detergent-soluble pool,…”
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New role for Agrin in T cells and its potential importance in immune system regulation by JURY, Elizabeth C, KABOURIDIS, Panagiotis S

“…Agrin plays a crucial role in the maintenance of the neuromuscular junction. However, it is expressed in other tissues as well, including T lymphocytes, where…”
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S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes by Kabouridis, Panagiotis S., Magee, Anthony I., Ley, Steven C.

“…LCK is a non‐receptor protein tyrosine kinase required for signal transduction via the T‐cell antigen receptor (TCR). LCK N‐terminus is S‐acylated on Cys3 and…”
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Agrin Signalling Contributes to Cell Activation and Is Overexpressed in T Lymphocytes from Lupus Patients by Jury, Elizabeth C, Eldridge, Jillian, Isenberg, David A, Kabouridis, Panagiotis S

“…It is shown in this study that the heparan sulfate proteoglycan agrin is overexpressed in T cells isolated from patients with the autoimmune disease systemic…”
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Regulation of T‐cell receptor signalling by membrane microdomains by Razzaq, Tahir M., Ozegbe, Patricia, Jury, Elizabeth C., Sembi, Phupinder, Blackwell, Nathan M., Kabouridis, Panagiotis S.

“…Summary There is now considerable evidence suggesting that the plasma membrane of mammalian cells is compartmentalized by functional lipid raft microdomains…”
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Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras by Malik, Nasser M., Gilroy, Derek W., Kabouridis, Panagiotis S.

“…We describe the development of cell-penetrating inhibitors of Ras and study their ability to inhibit T cell activation. The inhibitors transduced T cells in a…”
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Inhibition of NF-kappa B activity by a membrane-transducing mutant of I kappa B alpha by Kabouridis, Panagiotis S, Hasan, Maemunah, Newson, Justine, Gilroy, Derek W, Lawrence, Toby

“…The transcription factor NF-kappaB is regulated by the IkappaB family of proteins. The nonphosphorylatable, nondegradable superrepressor IkappaBalpha…”
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Regulation of expression and function of Lck tyrosine kinase by high cell density by Ozegbe, Patricia, Chernajovsky, Yuti, Kabouridis, Panagiotis S

“…For many types of cells, an increase in cell density leads to characteristic changes in intracellular signalling and cell function. It is unknown, however,…”
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Single chain antibodies specific for fatty acids derived from a semi-synthetic phage display library by Gargir, Ari, Ofek, Itzhak, Meron-Sudai, Shiri, Tanamy, Meital Gal, Kabouridis, Panagiotis S, Nissim, Ahuva

“…The biological activities of many acylated molecules are lipid dependent. Lipids, however, are poorly immunogenic or non-immunogenic. We employed a phage…”
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