Search Results - "Kabelitz, D."

Generation of Soluble NKG2D Ligands: Proteolytic Cleavage, Exosome Secretion and Functional Implications by Chitadze, G., Bhat, J., Lettau, M., Janssen, O., Kabelitz, D.

“…The activating natural killer group 2 member D (NKG2D) receptor is expressed on NK cells, cytotoxic T cells and additional T cell subsets. Ligands for human…”
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Lysosome‐Related Effector Vesicles in T Lymphocytes and NK Cells by Lettau, M., Kabelitz, D., Janssen, O.

“…Lysosome‐related secretory organelles combine metabolic functions of conventional lysosomes with an inducible secretory potential. Specialized variants of such…”
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The Multifunctionality of Human Vγ9Vδ2 γδ T Cells: Clonal Plasticity or Distinct Subsets? by Kabelitz, D., He, W.

“…The dominant subset of γδ T cells in human peripheral blood expresses Vγ9 paired with Vδ2 as variable TCR elements. Vγ9Vδ2 T cells recognize pyrophosphates…”
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Inhibition of Human γδ T Cell Proliferation and Effector Functions by Neutrophil Serine Proteases by Fazio, J., Kalyan, S., Wesch, D., Kabelitz, D.

“…Human peripheral blood γδ T cells expressing the Vγ9Vδ2 T cell receptor are activated by microbial or endogenous pyrophosphate antigens and indirectly by…”
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Inhibition of Human gamma delta T Cell Proliferation and Effector Functions by Neutrophil Serine Proteases by Fazio, J, Kalyan, S, Wesch, D, Kabelitz, D

“…Human peripheral blood gamma delta T cells expressing the V gamma 9V delta 2 T cell receptor are activated by microbial or endogenous pyrophosphate antigens…”
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Lysis of a Broad Range of Epithelial Tumour Cells by Human γδ T Cells: Involvement of NKG2D ligands and T-cell Receptor- versus NKG2D-dependent Recognition by Wrobel, P, Shojaei, H, Schittek, B, Gieseler, F, Wollenberg, B, Kalthoff, H, Kabelitz, D, Wesch, D

“…Human γδ T cells expressing a Vγ9Vδ2 T-cell receptor (TCR) kill various tumour cells including autologous tumours. In addition to TCR-dependent recognition,…”
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Effector memory T‑cells in the pathogenesis of ANCA-associated vasculitides by Kerstein, A., Müller, A., Kabelitz, D., Lamprecht, P.

“…Patients with antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) have an expansion of effector memory T‑cells in peripheral blood…”
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CD20‐Specific Immunoligands Engaging NKG2D Enhance γδ T Cell‐Mediated Lysis of Lymphoma Cells by Peipp, M., Wesch, D., Oberg, H.‐H., Lutz, S., Muskulus, A., Winkel, J. G. J., Parren, P. W. H. I., Burger, R., Humpe, A., Kabelitz, D., Gramatzki, M., Kellner, C.

“…Human γδ T cells are innate‐like T cells which are able to kill a broad range of tumour cells and thus may have potential for cancer immunotherapy. The…”
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Stochastics of Cellular Differentiation Explained by Epigenetics: The Case of T‐Cell Differentiation and Functional Plasticity by Bhat, J., Helmuth, J., Chitadze, G., Kouakanou, L., Peters, C., Vingron, M., Ammerpohl, O., Kabelitz, D.

“…Epigenetic marks including histone modifications and DNA methylation are associated with the regulation of gene expression and activity. In addition, an…”
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Modulation of CD4 T-cell activation by CD95 co-stimulation by Paulsen, M, Valentin, S, Mathew, B, Adam-Klages, S, Bertsch, U, Lavrik, I, Krammer, P H, Kabelitz, D, Janssen, O

“…CD95 is a dual-function receptor that exerts pro- or antiapoptotic effects depending on the cellular context, the state of activation, the signal threshold and…”
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Toll-Like Receptor Expression and Function in Subsets of Human gamma delta T Lymphocytes by Pietschmann, K, Beetz, S, Welte, S, Martens, I, Gruen, J, Oberg, H-H, Wesch, D, Kabelitz, D

“…AbstractTwo subsets of human gamma delta T cells can be identified by T cell receptor (TCR) V gene usage. V delta 2V gamma 9 T cells dominate in peripheral…”
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Toll-Like Receptor Expression and Function in Subsets of Human γδ T Lymphocytes by Pietschmann, K, Beetz, S, Welte, S, Martens, I, Gruen, J, Oberg, H.-H, Wesch, D, Kabelitz, D

“…Two subsets of human γδ T cells can be identified by T cell receptor (TCR) V gene usage. Vδ2Vγ9 T cells dominate in peripheral blood and recognize microbe- or…”
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Effector memory T‑cells in the pathogenesis of ANCA-associated vasculitides. German version by Kerstein, A, Müller, A, Kabelitz, D, Lamprecht, P

“…Patients with antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) have an expansion of effector memory T‑cells in peripheral blood…”
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Aminobisphosphonates and Toll-like receptor ligands: recruiting Vγ9Vδ2 T cells for the treatment of hematologic malignancy by Kalyan, S, Wesch, D, Kabelitz, D

“…Gamma delta (γδ) T cells are intrinsically important for preventing the development and progression of hematologic cancers. These innate T cells are…”
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Preferential activation of peripheral blood Vγ9+γ/δ T cells by group A, B and C but not group D or F streptococci by BENDER, A., KABELITZ, D.

“…SUMMARY Previous studies have established that inactivated mycobacteria are potent and selective activators of Vγ9+/Vδ2+ human γ/δ T cells. Here we have…”
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CD95 ligand - death factor and costimulatory molecule? by Janssen, O, Qian, J, Linkermann, A, Kabelitz, D

“…The CD95 ligand is involved as a death factor in the regulation of activation-induced cell death, establishment of immune privilege and tumor cell survival. In…”
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Markers of operational immune tolerance after pediatric liver transplantation in patients under immunosuppression by Schulz-Juergensen, S., Marischen, L., Wesch, D., Oberg, H. H., Fändrich, F., Kabelitz, D., Burdelski, M.

“…A prospective identification of the estimated 20–50% of pediatric LTX recipients developing operational tolerance would be of great clinical advantage. So far…”
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Adverse effects of intradermal allogeneic lymphocyte immunotherapy: acute reactions and role of autoimmunity by Kling, C., Steinmann, J., Westphal, E., Magez, J., Kabelitz, D.

“…BACKGROUND: Immunotherapy with allogeneic lymphocytes was introduced as a therapeutic option for selected infertile couples in different centres worldwide 20…”
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Identification of HLA-A0201-presented T-cell epitopes derived from the tumor-associated antigen M-phase phosphoprotein II in patients with acute myeloid leukemia by Siegel, S, Wirth, S, Kabelitz, D, Schmitz, N, Zeis, M

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Human γδ T Cells Produce the Protease Inhibitor and Antimicrobial Peptide Elafin by Marischen, L, Wesch, D, Schröder, J.-M, Wiedow, O, Kabelitz, D

“…Human γδ T cells rapidly secrete pro-inflammatory cytokines in response to T cell receptor-dependent recognition of pyrophosphates produced by many bacteria…”
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