Search Results - "Kabakov, Alexander E."

Hypoxia-Induced Cancer Cell Responses Driving Radioresistance of Hypoxic Tumors: Approaches to Targeting and Radiosensitizing by Kabakov, Alexander E, Yakimova, Anna O

“…Within aggressive malignancies, there usually are the "hypoxic zones"-poorly vascularized regions where tumor cells undergo oxygen deficiency through…”
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HSP70s in Breast Cancer: Promoters of Tumorigenesis and Potential Targets/Tools for Therapy by Kabakov, Alexander E, Gabai, Vladimir L

“…The high frequency of breast cancer worldwide and the high mortality among women with this malignancy are a serious challenge for modern medicine. A deeper…”
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Induction of Hsp70 in tumor cells treated with inhibitors of the Hsp90 activity: A predictive marker and promising target for radiosensitization by Kudryavtsev, Vladimir A, Khokhlova, Anna V, Mosina, Vera A, Selivanova, Elena I, Kabakov, Alexander E

“…We studied a role of the inducible heat shock protein 70 (Hsp70) in cellular response to radiosensitizing treatments with inhibitors of the heat shock protein…”
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Regulation of stress-induced intracellular sorting and chaperone function of Hsp27 (HspB1) in mammalian cells by Bryantsev, Anton L, Kurchashova, Svetlana Yu, Golyshev, Sergey A, Polyakov, Vladimir Yu, Wunderink, Herman F, Kanon, Bart, Budagova, Karina R, Kabakov, Alexander E, Kampinga, Harm H

“…In vitro, small Hsps (heat-shock proteins) have been shown to have chaperone function capable of keeping unfolded proteins in a form competent for…”
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Radiosensitization of Human Vascular Endothelial Cells Through Hsp90 Inhibition With 17- N -Allilamino-17-Demethoxygeldanamycin by Kabakov, Alexander E., Ph.D, Makarova, Yulia M., M.Sc, Malyutina, Yana V., M.Sc

“…Purpose In addition to invasive tumor cells, endothelial cells (ECs) of the tumor vasculature are an important target for anticancer radiotherapy. The purpose…”
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Overexpression of the Cochaperone CHIP Enhances Hsp70-Dependent Folding Activity in Mammalian Cells by Kampinga, Harm H., Kanon, Bart, Salomons, Florian A., Kabakov, Alexander E., Patterson, Cam

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cell Death and Survival Assays by Kabakov, Alexander E, Gabai, Vladimir L

“…Heat shock proteins are well-known protectors from cell death. Cell death (in particular, apoptosis and necrosis) is accompanied by certain hallmarks…”
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Stressful preconditioning and HSP70 overexpression attenuate proteotoxicity of cellular ATP depletion by Kabakov, Alexander E, Budagova, Karina R, Latchman, David S, Kampinga, Harm H

“…Rat H9c2 myoblasts were preconditioned by heat or metabolic stress followed by recovery under normal conditions. Cells were then subjected to severe ATP…”
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Heat shock protein 70 or heat shock protein 27 overexpressed in human endothelial cells during posthypoxic reoxygenation can protect from delayed apoptosis by Kabakov, Alexander E., Budagova, Karina R., Bryantsev, Anton L., Latchman, David S.

“…Overexpression of heat shock protein (Hsp) 70 and Hsp27 in vivo was proclaimed as a potential tool in therapy of ischemia-reperfusion injury. However, it was…”
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Hsp90 inhibitors as promising agents for radiotherapy by Kabakov, Alexander E., Kudryavtsev, Vladimir A., Gabai, Vladimir L.

“…The 90-kD heat shock protein (Hsp90) is an abundant molecular chaperone catalyzing maturation and activation of client proteins. A number of the Hsp90 client…”
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Distribution, phosphorylation, and activities of Hsp25 in heat-stressed H9c2 myoblasts: a functional link to cytoprotection by Bryantsev, Anton L., Loktionova, Svetlana A., Ilyinskaya, Olga P., Tararak, Eduard M., Kampinga, Harm H., Kabakov, Alexander E.

“…The behavior of the endogenous heat shock protein 25 (Hsp25) in heat-stressed rat H9c2 myoblasts was studied. After mild or severe heating, this protein became…”
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Early and delayed tolerance to simulated ischemia in heat-preconditioned endothelial cells: a role for HSP27 by Loktionova, S A, Ilyinskaya, O P, Kabakov, A E

“…An ischemia-mimicking metabolic stress in cultured endothelial cells from the human aorta or umbilical vein caused ATP depletion, a rise in cytosolic free…”
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Modulation of in Vivo HSP70 Chaperone Activity by Hip and Bag-1 by Nollen, Ellen A.A., Kabakov, Alexander E., Brunsting, Jeanette F., Kanon, Bart, Höhfeld, Jörg, Kampinga, Harm H.

“…The chaperone activity of Hsp70 is influenced by the activities of both positive and negative regulatory proteins. In this study, we provide first time…”
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Hsf1-Mediated Stress Response can Transiently Enhance Cellular Radioresistance by Kabakov, Alexander E., Malyutina, Yana V., Latchman, David S.

“…Kabakov, A. E., Malyutina, Y. V. and Latchman, D. S. Hsf1-Mediated Stress Response can Transiently Enhance Cellular Radioresistance. Radiat. Res. 165, 410–423…”
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Determination of cell survival or death by Kabakov, Alexander E, Kudryavtsev, Vladimir A, Gabai, Vladimir L

“…Cell death (in particular, apoptosis and necrosis) is accompanied by appearance of certain hallmarks that are manifested as specific alterations in cellular…”
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Heat Shock-Induced Accumulation of 70-kDa Stress Protein (HSP70) Can Protect ATP-Depleted Tumor Cells from Necrosis by Kabakov, Alexander E., Gabai, Vladimir L.

“…The phenomenon of cell resistance to prolonged energy deprivation after mild thermal stress was studied in vitro. Murine P 3 O 1 myeloma and Ehrlich ascites…”
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Oncomatrix: Molecular Composition and Biomechanical Properties of the Extracellular Matrix in Human Tumors by Klabukov, Ilya, Smirnova, Anna, Yakimova, Anna, Kabakov, Alexander E., Atiakshin, Dmitri, Petrenko, Daria, Shestakova, Victoria A., Sulina, Yana, Yatsenko, Elena, Stepanenko, Vasiliy N., Ignatyuk, Michael, Evstratova, Ekaterina, Krasheninnikov, Michael, Sosin, Dmitry, Baranovskii, Denis, Ivanov, Sergey, Shegay, Peter, Kaprin, Andrey D.

“…The extracellular matrix is an organized three-dimensional network of protein-based molecules and other macromolecules that provide structural and biochemical…”
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Biology Contribution: Radiosensitization of Human Vascular Endothelial Cells Through Hsp90 Inhibition With 17-N-Allilamino-17-Demethoxygeldanamycin by Kabakov, Alexander E, Makarova, Yulia M, Malyutina, Yana V

“…Purpose: In addition to invasive tumor cells, endothelial cells (ECs) of the tumor vasculature are an important target for anticancer radiotherapy. The purpose…”
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Hsp90 inhibitors as promising agents for radiotherapy by KABAKOV, Alexander E, KUDRYAVTSEV, Vladimir A, GABAI, Vladimir L

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Protein phosphatase inhibitors and heat preconditioning prevent Hsp27 dephosphorylation, F-actin disruption and deterioration of morphology in ATP-depleted endothelial cells by Loktionova, Svetlana A., Kabakov, Alexander E.

“…The vascular endothelium response to ischemic depletion of ATP was studied in vitro. Endothelial cells (EC) cultured from human aorta or umbilical vein were…”
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