Search Results - "Kaarniranta, Kai"

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network by Salminen, Antero, Kaarniranta, Kai

“…Highlights ► AMPK regulates energy metabolic homeostasis and cell survival during stress. ► AMPK coordinates signaling of many age-related transcription factor…”
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ER stress activates immunosuppressive network: implications for aging and Alzheimer’s disease by Salminen, Antero, Kaarniranta, Kai, Kauppinen, Anu

“…The endoplasmic reticulum (ER) contains stress sensors which recognize the accumulation of unfolded proteins within the lumen of ER, and subsequently these…”
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Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease by Salminen, Antero, Kauppinen, Anu, Kaarniranta, Kai

“…Alzheimer's disease (AD) is associated with deficiencies in cerebrovascular functions, e.g. reduced cerebral blood flow and capillary amyloid angiopathy, both…”
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Interplay between Autophagy and the Ubiquitin-Proteasome System and Its Role in the Pathogenesis of Age-Related Macular Degeneration by Blasiak, Janusz, Pawlowska, Elzbieta, Szczepanska, Joanna, Kaarniranta, Kai

“…Age-related macular degeneration (AMD) is a complex eye disease with many pathogenesis factors, including defective cellular waste management in retinal…”
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Role of Mitochondrial DNA Damage in ROS-Mediated Pathogenesis of Age-Related Macular Degeneration (AMD) by Kaarniranta, Kai, Pawlowska, Elzbieta, Szczepanska, Joanna, Jablkowska, Aleksandra, Blasiak, Janusz

“…Age-related macular degeneration (AMD) is a complex eye disease that affects millions of people worldwide and is the main reason for legal blindness and vision…”
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Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process by Salminen, Antero, Kaarniranta, Kai, Kauppinen, Anu

“…Increased oxidative stress has been associated with the aging process. However, recent studies have revealed that a low-level oxidative stress can even extend…”
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Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways by Salminen, Antero, Kaarniranta, Kai, Kauppinen, Anu

“…Highlights • AMPK signaling controls the aging process via an integrated signaling network. • AMPK signaling declines with aging enhancing the aging process. •…”
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Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases by Salminen, Antero, Ojala, Johanna, Kaarniranta, Kai, Kauppinen, Anu

“…Oxidative stress and low-grade inflammation are the hallmarks of the aging process and are even more enhanced in many age-related degenerative diseases…”
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Regulation of the aging process by autophagy by Salminen, Antero, Kaarniranta, Kai

“…Autophagy is involved in cellular protein and organelle degradation, which is mediated by the lysosomal pathway. Autophagocytosis has a key role in cellular…”
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Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases by Salminen, Antero, Kaarniranta, Kai, Kauppinen, Anu

“…Background The insulin/IGF-1 signaling pathway has a major role in the regulation of longevity both in Caenorhabditis elegans and mammalian species, i.e.,…”
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Regulation of longevity by FGF21: interaction between energy metabolism and stress responses by Salminen, Antero, Kaarniranta, Kai, Kauppinen, Anu

“…Highlights • FGF21, an endocrine factor, controls energy metabolism and acts as stress hormone. • FGF21 regulates energy metabolism and stress responses via…”
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A Linkage between Angiogenesis and Inflammation in Neovascular Age-Related Macular Degeneration by Heloterä, Hanna, Kaarniranta, Kai

“…Age-related macular degeneration (AMD) is the leading cause of visual impairment in the aging population with a limited understanding of its pathogenesis and…”
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PGC-1α Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD Pathogenesis by Kaarniranta, Kai, Kajdanek, Jakub, Morawiec, Jan, Pawlowska, Elzbieta, Blasiak, Janusz

“…PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) is a transcriptional coactivator of many genes involved in energy management and…”
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AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions by Salminen, Antero, Kauppinen, Anu, Kaarniranta, Kai

“…AMP-activated protein kinase (AMPK) and its yeast homolog, Snf1, are critical regulators in the maintenance of energy metabolic balance not only stimulating…”
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Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome by Salminen, Antero, Kaarniranta, Kai, Kauppinen, Anu, Ojala, Johanna, Haapasalo, Annakaisa, Soininen, Hilkka, Hiltunen, Mikko

“…The accumulation of amyloid-β-containing neuritic plaques and intracellular tau protein tangles are key histopathological hallmarks of Alzheimer's disease…”
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Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration by Kaarniranta, Kai, Tokarz, Paulina, Koskela, Ali, Paterno, Jussi, Blasiak, Janusz

“…Age-related macular degeneration (AMD) is an eye disease underlined by the degradation of retinal pigment epithelium (RPE) cells, photoreceptors, and…”
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Maturation of autophagosomes and endosomes: A key role for Rab7 by Hyttinen, Juha M.T., Niittykoski, Minna, Salminen, Antero, Kaarniranta, Kai

“…Macroautophagy is an important route in cellular maintenance, in the breakdown and reuse of intracellular materials. It is closely related to endocytosis, the…”
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Dietary Polyphenols in Age-Related Macular Degeneration: Protection against Oxidative Stress and Beyond by Kaarniranta, Kai, Koskela, Ali, Szczepanska, Joanna, Pawlowska, Elzbieta, Blasiak, Janusz

“…Age-related macular degeneration (AMD) is a multifactorial disease of the retina featured by degeneration and loss of photoreceptors and retinal pigment…”
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Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process by Salminen, Antero, Kaarniranta, Kai, Kauppinen, Anu

“…Highlights ► Beclin 1 interactome controls autophagy and endocytosis. ► Anti-apoptotic Bcl-2 family members inhibit autophagocytosis. ► Impaired autophagy…”
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Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD) by Tokarz, Paulina, Kaarniranta, Kai, Blasiak, Janusz

“…Cells in aerobic condition are constantly exposed to reactive oxygen species (ROS), which may induce damage to biomolecules, including proteins, nucleic acids…”
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