Search Results - "Kaakkola, Seppo"

Gut microbiota are related to Parkinson's disease and clinical phenotype by Scheperjans, Filip, Aho, Velma, Pereira, Pedro A. B., Koskinen, Kaisa, Paulin, Lars, Pekkonen, Eero, Haapaniemi, Elena, Kaakkola, Seppo, Eerola-Rautio, Johanna, Pohja, Marjatta, Kinnunen, Esko, Murros, Kari, Auvinen, Petri

“…In the course of Parkinson's disease (PD), the enteric nervous system (ENS) and parasympathetic nerves are amongst the structures earliest and most frequently…”
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ATPase-deficient mitochondrial inner membrane protein ATAD3A disturbs mitochondrial dynamics in dominant hereditary spastic paraplegia by Cooper, Helen M, Yang, Yang, Ylikallio, Emil, Khairullin, Rafil, Woldegebriel, Rosa, Lin, Kai-Lan, Euro, Liliya, Palin, Eino, Wolf, Alexander, Trokovic, Ras, Isohanni, Pirjo, Kaakkola, Seppo, Auranen, Mari, Lönnqvist, Tuula, Wanrooij, Sjoerd, Tyynismaa, Henna

“…De novo mutations in ATAD3A (ATPase family AAA-domain containing protein 3A) were recently found to cause a neurological syndrome with developmental delay,…”
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Linking Smoking, Coffee, Urate, and Parkinson's Disease - A Role for Gut Microbiota? by Scheperjans, Filip, Pekkonen, Eero, Kaakkola, Seppo, Auvinen, Petri

“…While the etiology and pathogenesis of Parkinson's disease (PD) is still obscure, there is evidence for lifestyle factors influencing disease risk. Best…”
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SNCA mutation p.Ala53Glu is derived from a common founder in the Finnish population by Pasanen, Petra, Palin, Eino, Pohjolan-Pirhonen, Risto, Pöyhönen, Minna, Rinne, Juha O, Päivärinta, Markku, Martikainen, Mika H, Kaasinen, Valtteri, Hietala, Marja, Gardberg, Maria, Saukkonen, Anna Maija, Eerola-Rautio, Johanna, Kaakkola, Seppo, Lyytinen, Jukka, Tienari, Pentti J, Paetau, Anders, Suomalainen, Anu, Myllykangas, Liisa

“…Abstract Mutations in SNCA are rare causes of familial Parkinson’s disease (PD). We have previously described a novel p.Ala53Glu mutation in two Finnish…”
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Dopamine modulates involuntary attention shifting and reorienting: an electromagnetic study by Kähkönen, Seppo, Ahveninen, Jyrki, Pekkonen, Eero, Kaakkola, Seppo, Huttunen, Juha, Ilmoniemi, Risto J, Jääskeläinen, Iiro P

“…Objective: Dopaminergic function has been closely associated with attentional performance, but its precise role has remained elusive. Methods:…”
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Auditory Sensory Memory and the Cholinergic System: Implications for Alzheimer's Disease by Pekkonen, Eero, Hirvonen, Jyrki, Jääskeläinen, Iiro P., Kaakkola, Seppo, Huttunen, Juha

“…Auditory sensory memory represents one of the simplest types of short-term memory that can be studied electrophysiologically with mismatch negativity (MMN); a…”
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A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology by Pasanen, Petra, Myllykangas, Liisa, Siitonen, Maija, Raunio, Anna, Kaakkola, Seppo, Lyytinen, Jukka, Tienari, Pentti J, Pöyhönen, Minna, Paetau, Anders

“…Abstract We describe the clinical, neuropathological, and genetic features of a Finnish patient with a novel α-synuclein ( SNCA ) mutation A53E. The patient…”
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Entacapone improves the availability of l‐dopa in plasma by decreasing its peripheral metabolism independent of l‐dopa/carbidopa dose by Heikkinen, Helena, Varhe, Anu, Laine, Tarmo, Puttonen, Jaakko, Kela, Marjo, Kaakkola, Seppo, Reinikainen, Kari

“…Aims Entacapone is a peripherally acting catechol‐O‐methyltransferase (COMT) inhibitor. To improve the benefits of oral l‐dopa in the treatment of Parkinson's…”
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Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinson's disease by Kaakkola, Seppo

“…Entacapone and tolcapone are reversible COMT inhibitors which have been approved for clinical use in patients with Parkinson disease (PD). Nebicapone is a…”
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Effects of an acute D2-dopaminergic blockade on the somatosensory cortical responses in healthy humans: evidence from evoked magnetic fields by Huttunen, Juha, Kähkönen, Seppo, Kaakkola, Seppo, Ahveninen, Jyrki, Pekkonen, Eero

“…We tested the possible role of dopaminergic activity in the processing of somatosensory afferent information in healthy humans. Somatosensory evoked magnetic…”
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Clinical pharmacology, therapeutic use and potential of COMT inhibitors in Parkinson's disease by KAAKKOLA, S

“…When peripheral decarboxylation is blocked by carbidopa or benserazide, the main metabolic pathway of levodopa is O-methylation by catechol-O-methyltransferase…”
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Musculoskeletal Symptoms Among Finnish Professional Orchestra Musicians by Viljamaa, Katriina, Liira, Juha, Kaakkola, Seppo, Savolainen, Aslak

“…BACKGROUND: The prevalence of musculoskeletal symptoms is high among professional musicians (73-88%). AIMS: We investigated the prevalence of musculoskeletal…”
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Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors by Männistö, P T, Kaakkola, S

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Experimental and alternative ways of drug treatment of Parkinson's disease by Kaakkola, Seppo

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Mitochondrial DNA Polymerase W748S Mutation: A Common Cause of Autosomal Recessive Ataxia with Ancient European Origin by Hakonen, Anna H., Heiskanen, Silja, Juvonen, Vesa, Lappalainen, Ilse, Luoma, Petri T., Rantamäki, Maria, Goethem, Gert Van, Löfgren, Ann, Hackman, Peter, Paetau, Anders, Kaakkola, Seppo, Majamaa, Kari, Varilo, Teppo, Udd, Bjarne, Kääriäinen, Helena, Bindoff, Laurence A., Suomalainen, Anu

“…Mutations in the catalytic subunit of the mitochondrial DNA polymerase γ (POLG) have been found to be an important cause of neurological disease. Recently, we…”
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Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat by Nissinen, E, Lindén, I B, Schultz, E, Kaakkola, S, Männistö, P T, Pohto, P

“…Catechol-O-methyltransferase (COMT) has an important role in the extraneuronal inactivation of catecholamine neurotransmitters and drugs with a catechol…”
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Comparison of pharmacokinetic profile of levodopa throughout the day between levodopa/carbidopa/entacapone and levodopa/carbidopa when administered four or five times daily by Kuoppamäki, Mikko, Korpela, Kirsi, Marttila, Reijo, Kaasinen, Valtteri, Hartikainen, Päivi, Lyytinen, Jukka, Kaakkola, Seppo, Hänninen, Jutta, Löyttyniemi, Eliisa, Kailajärvi, Marita, Ruokoniemi, Päivi, Ellmén, Juha

“…Objectives To compare plasma levodopa concentrations after repeated doses of levodopa/carbidopa/entacapone (LCE) and levodopa/carbidopa (LC). Methods…”
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Defective cortical drive to muscle in Parkinson's disease and its improvement with levodopa by SALENIUS, Stephan, AVIKAINEN, Sari, KAAKKOLA, Seppo, HARI, Riitta, BROWN, Peter

“…We recorded whole-scalp magnetoencephalographic (MEG) signals simultaneously with surface electromyographic (EMG) activity from eight patients with Parkinson's…”
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Cholinergic modulation of preattentive auditory processing in aging by Pekkonen, Eero, Jääskeläinen, Iiro P., Kaakkola, Seppo, Ahveninen, Jyrki

“…Auditory event-related potential (ERP) components P50 and N100 are thought to index preattentive auditory processing underlying stimulus detection, whereas a…”
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Clinical Pharmacology, Therapeutic Use and Potential of COMT Inhibitors in Parkinson???s Disease by Kaakkola, Seppo

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