Search Results - "KYLE, A. H"

Tissue Discs: A 3D Model for Assessing Modulation of Tissue Oxygenation by Gandolfo, M J, Kyle, A H, Minchinton, A I

“…The presence of hypoxia in solid tumours is correlated with poor treatment outcome. We have developed a 3-D tissue engineered construct to quantitatively…”
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Measurement of delivery and metabolism of tirapazamine to tumour tissue using the multilayered cell culture model by KYLE, A. H, MINCHINTON, A. I

“…Efficient extravascular penetration is essential for the optimal activity of most anticancer drugs and is particularly relevant to bioreductive cytotoxins…”
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Vascularization predicts overall survival and risk of transformation in follicular lymphoma by FARINHA, Pedro, KYLE, Alastair H, MINCHINTON, Andrew I, CONNORS, Joseph M, KARSAN, Aly, GASCOYNE, Randy D

“…Follicular lymphoma patients display heterogeneous overall survival and variable risk of transformation. Recent studies have highlighted the role of the…”
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Characterization of Three-Dimensional Tissue Cultures Using Electrical Impedance Spectroscopy by Kyle, Alastair H., Chan, Carmel T.O., Minchinton, Andrew I.

“…Electrical impedance spectroscopy was used to characterize the cell environment of multilayered cell cultures (MCCs), a culture system in which cells are grown…”
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Microregional effects of gemcitabine in HCT-116 xenografts by HUXHAM, Lynsey A, KYLE, Alastair H, BAKER, Jennifer H. E, NYKILCHUK, Lani K, MINCHINTON, Andrew I

“…To examine the tumor microregional effects after gemcitabine administration to mice, we mapped the location of proliferating and hypoxic cells relative to…”
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Direct assessment of drug penetration into tissue using a novel application of three-dimensional cell culture by KYLE, Alastair H, HUXHAM, Lynsey A, CHIAM, Aaron S. J, SIM, David H, MINCHINTON, Andrew I

“…The failure of many anticancer drugs to control growth of solid cancers may stem in part from inadequate delivery to tumor regions distant from vasculature…”
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Tirapazamine causes vascular dysfunction in HCT-116 tumour xenografts by Huxham, Lynsey A., Kyle, Alastair H., Baker, Jennifer H.E., McNicol, Krista L., Minchinton, Andrew I.

“…Tirapazamine is a hypoxic cytotoxin currently undergoing Phase II/III clinical evaluation in combination with radiation and chemotherapeutics for the treatment…”
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Tumor distribution of bromodeoxyuridine-labeled cells is strongly dose dependent by KYLE, Alastair H, HUXHAM, Lynsey A, BAKER, Jennifer H. E, BURSTON, Helen E, MINCHINTON, Andrew I

“…Bromodeoxyuridine (BrdUrd) is used extensively to measure the fraction of proliferating cells in tumors. Unlike endogenous markers of proliferation such as…”
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Vascular-specific quantification in an in vivo Matrigel chamber angiogenesis assay by Baker, Jennifer H.E., Huxham, Lynsey A., Kyle, Alastair H., Lam, Kevin K., Minchinton, Andrew I.

“…The study of angiogenesis as a therapeutic target requires reliable in vivo assays that can provide physiologically relevant data. A murine in vivo…”
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HER-2/neu overexpression increases the viable hypoxic cell population within solid tumors without causing changes in tumor vascularization by Dragowska, Wieslawa H, Warburton, Corinna, Yapp, Donald T T, Minchinton, Andrew I, Hu, Yanping, Waterhouse, Dawn N, Gelmon, Karen, Skov, Kirsten, Woo, Janet, Masin, Dana, Huxham, Lynsey A, Kyle, Alastair H, Bally, Marcel B

“…The effects of HER-2/neu overexpression on the tumor microenvironment in an aggressive breast cancer xenograft model were investigated. These studies focused…”
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Carbogen Breathing after Irradiation Enhances the Effectiveness of Tirapazamine in SiHa Tumors but not SCCVII Tumors in Mice by Minchinton, Andrew I., Tonn, Danika A., Sutherland, Darren P., Kyle, Alastair H.

“…Minchinton, A. I., Tonn, D. A., Sutherland, D. P. and Kyle, A. H. Carbogen Breathing after Irradiation Enhances the Effectiveness of Tirapazamine in SiHa…”
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