Search Results - "KWUN, Jean"

Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use by Kwun, Jean, Matignon, Marie, Manook, Miriam, Guendouz, Soulef, Audard, Vincent, Kheav, David, Poullot, Elsa, Gautreau, Chantal, Ezekian, Brian, Bodez, Diane, Damy, Thibault, Faivre, Laureline, Menouch, Dehbia, Yoon, Janghoon, Park, Jaeberm, Belhadj, Karim, Chen, Dongfeng, Bilewski, Alyssa M, Yi, John S, Collins, Bradley, Stegall, Mark, Farris, Alton B, Knechtle, Stuart, Grimbert, Philippe

“…Donor-specific antibodies are associated with increased risk of antibody-mediated rejection and decreased allograft survival. Therefore, reducing the risk of…”
Get full text

Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients by Burghuber, Christopher K., Manook, Miriam, Ezekian, Brian, Gibby, Adriana C., Leopardi, Frank V., Song, Minqing, Jenks, Jennifer, Saccoccio, Frances, Permar, Sallie, Farris, Alton B., Iwakoshi, Neal N., Kwun, Jean, Knechtle, Stuart J.

“…Previous evidence suggests that a homeostatic germinal center (GC) response may limit bortezomib desensitization therapy. We evaluated the combination of…”
Get full text

C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates by Schmitz, Robin, Fitch, Zachary W., Schroder, Paul M., Choi, Ashley Y., Manook, Miriam, Yoon, Janghoon, Song, Mingqing, Yi, John S., Khandelwal, Sanjay, Arepally, Gowthami M., Farris, Alton B., Reis, Edimara S., Lambris, John D., Kwun, Jean, Knechtle, Stuart J.

“…Sensitized kidney transplant recipients experience high rates of antibody-mediated rejection due to the presence of donor-specific antibodies and immunologic…”
Get full text

Immunothrombotic Activity of Damage-Associated Molecular Patterns and Extracellular Vesicles in Secondary Organ Failure Induced by Trauma and Sterile Insults by Eppensteiner, John, Davis, Robert Patrick, Barbas, Andrew S, Kwun, Jean, Lee, Jaewoo

“…Despite significant improvements in injury prevention and emergency response, injury-related death and morbidity continues to increase in the US and worldwide…”
Get full text

Emerging New Approaches in Desensitization: Targeted Therapies for HLA Sensitization by Choi, Ashley Y, Manook, Miriam, Olaso, Danae, Ezekian, Brian, Park, Jaeberm, Freischlag, Kyle, Jackson, Annette, Knechtle, Stuart, Kwun, Jean

“…There is an urgent need for therapeutic interventions for desensitization and antibody-mediated rejection (AMR) in sensitized patients with preformed or…”
Get full text

Complement-targeted therapies in kidney transplantation-insights from preclinical studies by Anwar, Imran J, DeLaura, Isabel, Ladowski, Joseph, Gao, Qimeng, Knechtle, Stuart J, Kwun, Jean

“…Aberrant activation of the complement system contributes to solid-organ graft dysfunction and failure. In kidney transplantation, the complement system is…”
Get full text

Acoustofluidic-based therapeutic apheresis system by Wu, Mengxi, Ma, Zhiteng, Xu, Xianchen, Lu, Brandon, Gu, Yuyang, Yoon, Janghoon, Xia, Jianping, Ma, Zhehan, Upreti, Neil, Anwar, Imran J., Knechtle, Stuart J., T. Chambers, Eileen, Kwun, Jean, Lee, Luke P., Huang, Tony Jun

“…Therapeutic apheresis aims to selectively remove pathogenic substances, such as antibodies that trigger various symptoms and diseases. Unfortunately, current…”
Get full text

Allo-Specific Humoral Responses: New Methods for Screening Donor-Specific Antibody and Characterization of HLA-Specific Memory B Cells by Song, Shengli, Manook, Miriam, Kwun, Jean, Jackson, Annette M, Knechtle, Stuart J, Kelsoe, Garnett

“…Antibody-mediated allograft rejection (AMR) causes more kidney transplant failure than any other single cause. AMR is mediated by antibodies recognizing…”
Get full text

Unique aspects of rejection and tolerance in liver transplantation by Knechtle, Stuart J, Kwun, Jean

“…Spontaneous acceptance of liver allografts occurs in several species. However, tolerance is rare in human transplant patients even though rejection is…”
Get more information

Editorial: Sensitization and Desensitization in Organ Transplantation by Anwar, Imran J, Jackson, Annette M, Locke, Jayme E, Kwun, Jean

Get full text

Harnessing the B Cell Response in Kidney Transplantation - Current State and Future Directions by Anwar, Imran J, DeLaura, Isabel F, Gao, Qimeng, Ladowski, Joseph, Jackson, Annette M, Kwun, Jean, Knechtle, Stuart J

“…Despite dramatic improvement in kidney transplantation outcomes over the last decades due to advent of modern immunosuppressive agents, long-term outcomes…”
Get full text

Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model by Manook, Miriam, Flores, Walter J, Schmitz, Robin, Fitch, Zachary, Yoon, Janghoon, Bae, Yeeun, Shaw, Brian, Kirk, Allan, Harnois, Melissa, Permar, Sallie, Farris, Alton B, Magnani, Diogo M, Kwun, Jean, Knechtle, Stuart

“…In transplantation, plasmapheresis and IVIg provide the mainstay of treatment directed at reducing or removing circulating donor-specific antibody (DSA), yet…”
Get full text

Translation of therapeutic strategies to modulate B cell reponses from non-human primate models to human kidney transplantation by Knechtle, Stuart, Kwun, Jean, Song, Shengli, Jackson, Annette, Williams, Kitza, Sanoff, Scott

“…Using novel drugs targeting lymphocyte costimulation, cytokines, antibody, complement, and plasma cells, we have developed strategies in a non-human primate…”
Get full text

Damage- and pathogen-associated molecular patterns play differential roles in late mortality after critical illness by Eppensteiner, John, Kwun, Jean, Scheuermann, Uwe, Barbas, Andrew, Limkakeng, Alexander T, Kuchibhatla, Maggie, Elster, Eric A, Kirk, Allan D, Lee, Jaewoo

“…Multiple organ failure (MOF) is the leading cause of late mortality and morbidity in patients who are admitted to intensive care units (ICUs). However, there…”
Get full text

Single cell transcriptomics of mouse kidney transplants reveals a myeloid cell pathway for transplant rejection by Dangi, Anil, Natesh, Naveen R, Husain, Irma, Ji, Zhicheng, Barisoni, Laura, Kwun, Jean, Shen, Xiling, Thorp, Edward B, Luo, Xunrong

“…Myeloid cells are increasingly recognized as major players in transplant rejection. Here, we used a murine kidney transplantation model and single cell…”
Get full text

An acoustofluidic device for the automated separation of platelet-reduced plasma from whole blood by Ma, Zhehan, Xia, Jianping, Upreti, Neil, David, Emeraghi, Rufo, Joseph, Gu, Yuyang, Yang, Kaichun, Yang, Shujie, Xu, Xiangchen, Kwun, Jean, Chambers, Eileen, Huang, Tony Jun

“…Separating plasma from whole blood is an important sample processing technique required for fundamental biomedical research, medical diagnostics, and…”
Get full text

A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines by Song, Shengli, Manook, Miriam, Kwun, Jean, Jackson, Annette M., Knechtle, Stuart J., Kelsoe, Garnett

“…Multiplex immunoassays with acellular antigens are well-established based on solid-phase platforms such as the Luminex ® technology. Cell barcoding by…”
Get full text

Belatacept and carfilzomib-based treatment for antibody-mediated rejection in a sensitized nonhuman primate kidney transplantation model by Schmitz, Robin, Manook, Miriam, Fitch, Zachary, Anwar, Imran, DeLaura, Isabel, Olaso, Danae, Choi, Ashley, Yoon, Janghoon, Bae, Yeeun, Song, Mingqing, Farris, Alton B, Kwun, Jean, Knechtle, Stuart

“…One-third of HLA-incompatible kidney transplant recipients experience antibody mediated rejection (AMR) with limited treatment options. This study describes a…”
Get full text

IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade by Kwun, Jean, Park, Jaeberm, Yi, John S, Farris, Alton B, Kirk, Allan D, Knechtle, Stuart J

“…Despite its excellent efficacy in controlling T cell mediated acute rejection, lymphocyte depletion may promote a humoral response. While T cell repopulation…”
Get full text

Commentary: Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation by Schroder, Paul M, Ezekian, Brian, Ford, Mandy, Knechtle, Stuart J, Kwun, Jean

Get full text