Search Results - "KWON, E. D"

Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade by HURWITZ, A. A, FOSTER, B. A, KWON, E. D, TRUONG, T, CHOI, E. M, GREENBERG, N. M, BURG, M. B, ALLISON, J. P

“…We have previously shown that antibodies to CTLA-4, an inhibitory receptor on T cells, can be effective at inducing regression of transplantable murine tumors…”
Get full text

Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model by FOSTER, B. A, GINGRICH, J. R, KWON, E. D, MADIAS, C, GREENBERG, N. M

“…To develop a syngeneic transplantable system to study immunotherapeutic approaches for the treatment of prostate cancer, three cell lines were established from…”
Get full text

Alterations in peripheral B cells and B cell progenitors following androgen ablation in mice by Ellis, Thomas M., Moser, Michael T., Le, Phong T., Flanigan, Robert C., Kwon, Eugene D.

“…The production of B lymphocytes is regulated in part by physiologic levels of androgens and estrogens. While these sex hormones down-regulate B lymphopoiesis,…”
Get full text

Impact of single-agent daily prednisone on outcomes in men with metastatic castration-resistant prostate cancer by Sonpavde, G, Pond, G R, Templeton, A J, Kwon, E D, De Bono, J S

“…Background: Despite palliative benefits and PSA responses, the objective clinical impact of daily oral prednisone (P) for metastatic castration-resistant…”
Get full text

Clinical Significance of Defective Dendritic Cell Differentiation in Cancer by Almand, B, Resser, J R, Lindman, B, Nadaf, S, Clark, J I, Kwon, E D, Carbone, D P, Gabrilovich, D I

“…Defective dendritic cell (DC) function has been described previously in cancer patients and tumor-bearing mice. It can be an important factor in the escape of…”
Get full text

Osmoregulation of GPC:choline phosphodiesterase in MDCK cells: different effects of urea and NaCl by Kwon, E D, Zablocki, K, Jung, K Y, Peters, E M, García-Pérez, A, Burg, M B

“…The organic osmolyte, glycerophosphocholine (GPC), accumulates in renal cells in response to high concentrations of either NaCl or urea, despite the very…”
Get full text

T Cell Infiltration of the Prostate Induced by Androgen Withdrawal in Patients with Prostate Cancer by Mercader, Maria, Bodner, Barbara K., Moser, Micheal T., Kwon, Pamela S., Eugene S. Y. Park, Manecke, Ryan G., Ellis, Thomas M., Wojcik, Eva M., Yang, Damu, Flanigan, Robert C., Waters, W. Bedford, Kast, W. Martin, Kwon, Eugene D.

“…Manipulations capable of breaking host tolerance to induce tissue-specific T cell-mediated inflammation are of central importance to tumor immunotherapy and…”
Get full text

Osmotic regulation of synthesis of glycerophosphocholine from phosphatidylcholine in MDCK cells by Kwon, E D, Jung, K Y, Edsall, L C, Kim, H Y, García-Pérez, A, Burg, M B

“…Glycerophosphocholine (GPC) is osmotically regulated in renal medullary cells and in cultured Madin-Darby canine kidney (MDCK) cells. Previously, it was shown…”
Get full text

Regulation of gene expression by hypertonicity by Burg, M B, Kwon, E D, Kültz, D

“…Adaptation of cells to hypertonicity often involves changes in gene expression. Since the concentration of salt in the interstitial fluid surrounding renal…”
Get full text

Organic osmolyte distribution and levels in the mammalian urinary bladder in diuresis and antidiuresis by Kwon, E D, Dooley, J A, Jung, K Y, Andrews, P M, García-Pérez, A, Burg, M B

“…Inositol, sorbitol, glycerophosphocholine (GPC), and betaine are organic osmolytes that are accumulated by renal medullary cells in response to hyperosmotic…”
Get full text

Elimination of Residual Metastatic Prostate Cancer after Surgery and Adjunctive Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA-4) Blockade Immunotherapy by Kwon, Eugene D., Foster, Barbara A., Hurwitz, Arthur A., Madias, Chris, Allison, James P., Greenberg, Norman M., Burg, Maurice B.

“…Cancer relapse after surgery is a common occurrence, most frequently resulting from the outgrowth of minimal residual disease in the form of metastases. We…”
Get full text

Manipulation of T Cell Costimulatory and Inhibitory Signals for Immunotherapy of Prostate Cancer by Kwon, Eugene D., Hurwitz, Arthur A., Foster, Barbara A., Madias, Christopher, Feldhaus, Andrew L., Greenberg, Norman M., Burg, Maurice B., Allison, James P.

“…The identification of potentially useful immune-based treatments for prostate cancer has been severely constrained by the scarcity of relevant animal research…”
Get full text

Betaine and inositol reduce MDCK cell glycerophosphocholine by stimulating its degradation by Kwon, E D, Zablocki, K, Peters, E M, Jung, K Y, García-Pérez, A, Burg, M B

“…The amount of glycerophosphocholine (GPC) in renal medullary cells in vivo and in cultured renal [Madin-Darby canine kidney (MDCK)] cells varies with…”
Get full text

Osmotic regulation of gene expression by Burg, M B, Kwon, E D, Kültz, D

“…Cells react to increased osmolality with numerous changes in gene expression. The specific genes affected differ between species, but the known osmoprotective…”
Get more information

Murine six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen : Prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice by DAMU YANG, HOLT, Gregory E, VELDERS, Markwin P, KWON, Eugene D, KAST, W. Martin

“…To identify genes that are differentially up-regulated in prostate cancer of transgenic adenocarcinoma mouse prostate (TRAMP) mice, we subtracted cDNA isolated…”
Get full text

Costimulatory wars: the tumor menace by Hurwitz, Arthur A, Kwon, Eugene D, van Elsas, Andrea

“…Advances in our understanding of T cell costimulatory molecules have provided a vast array of novel approaches to tumor immunotherapy. In the past year,…”
Get full text

Continent small-intestine reservoir construction : a tapered intussusceptum promotes sustained continence by DONOVAN, J. F, HADE, D. K, LAVELLE, J. P, KWON, E. D

“…Developed for the study of dialysis in the continent jejunal reservoir (CJR), a novel, uncomplicated approach to achieve continence in construction of a…”
Get full text

Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial by Kwon, Eugene D, Prof, Drake, Charles G, MD, Scher, Howard I, Prof, Fizazi, Karim, Prof, Bossi, Alberto, MD, van den Eertwegh, Alfons J M, MD, Krainer, Michael, MD, Houede, Nadine, MD, Santos, Ricardo, MD, Mahammedi, Hakim, MD, Ng, Siobhan, MD, Maio, Michele, MD, Franke, Fabio A, MD, Sundar, Santhanam, MBBS, Agarwal, Neeraj, MD, Bergman, Andries M, MD, Ciuleanu, Tudor E, Prof, Korbenfeld, Ernesto, MD, Sengeløv, Lisa, MD, Hansen, Steinbjorn, MD, Logothetis, Christopher, Prof, Beer, Tomasz M, Prof, McHenry, M Brent, PhD, Gagnier, Paul, MD, Liu, David, MD, Gerritsen, Winald R, Prof

“…Summary Background Ipilimumab is a fully human monoclonal antibody that binds cytotoxic T-lymphocyte antigen 4 to enhance antitumour immunity. Our aim was to…”
Get full text

Radical prostatectomy and adjuvant radioactive gold seed placement: results of treatment at 5 and 10 years for clinical stages A2, B1 and B2 cancer of the prostate by Kwon, E D, Loening, S A, Hawtrey, C E

“…Between 1977 and 1988, 131 patients with adenocarcinoma of the prostate underwent combined radical prostatectomy and intraoperative radioactive gold seed…”
Get more information

Physical Determinants of Solute and Water Clearance by the Perfused Dog Jejunum by Kwon, Eugene D., Donovan, James F., Schedl, Harold P.

“…We systematically compared the individual effects of infusion rate, solution osmolality, and temperature on plasma solute secretion during luminal perfusion of…”
Get full text