Search Results - "KWAAN, Hau C"

The Role of Fibrinolytic System in Health and Disease by Kwaan, Hau C

“…The fibrinolytic system is composed of the protease plasmin, its precursor plasminogen and their respective activators, tissue-type plasminogen activator (tPA)…”
Get full text

The Central Role of Fibrinolytic Response in COVID-19-A Hematologist's Perspective by Kwaan, Hau C, Lindholm, Paul F

“…The novel coronavirus disease (COVID-19) has many characteristics common to those in two other coronavirus acute respiratory diseases, severe acute respiratory…”
Get full text

Components of the Plasminogen-Plasmin System as Biologic Markers for Cancer by McMahon, Brandon J, Kwaan, Hau C

“…Members of the plasminogen-plasmin (PP) system participate in many physiologic functions. In particular, uPA, its receptor (uPAR) and its inhibitor PAI-1 play…”
Get more information

Role of plasma proteins in whole blood viscosity: a brief clinical review by Kwaan, Hau C

“…Whole blood viscosity is affected by a number of factors, among which plasma proteins are a major component. They exert their effects either directly or…”
Get more information

Desmopressin Improves Platelet Activity in Acute Intracerebral Hemorrhage by Naidech, Andrew M, Maas, Matthew B, Levasseur-Franklin, Kimberly E, Liotta, Eric M, Guth, James C, Berman, Micheal, Rosenow, Joshua M, Lindholm, Paul F, Bendok, Bernard R, Prabhakaran, Shyam, Bernstein, Richard A, Kwaan, Hau C

“…BACKGROUND AND PURPOSE—Minimizing hematoma growth in high-risk patients is an attractive strategy to improve outcomes after intracerebral hemorrhage. We tested…”
Get full text

The role of plasminogen-plasmin system in cancer by Kwaan, Hau C, McMahon, Brandon

“…Components of the plasminogen-plasmin system participate in a wide variety of physiologic and pathologic processes, including tumor growth, invasion and…”
Get more information

The coagulopathy in acute promyelocytic leukaemia – What have we learned in the past twenty years by Kwaan, Hau C., MD, FRCP, Cull, Elizabeth H., MD

“…Coagulopathy is a unique component of the pathology of acute promyelocytic leukaemia (APL). Though many causative factors have been elucidated, therapies to…”
Get full text

SHock-INduced Endotheliopathy (SHINE): A mechanistic justification for viscoelastography-guided resuscitation of traumatic and non-traumatic shock by Bunch, Connor M, Chang, Eric, Moore, Ernest E, Moore, Hunter B, Kwaan, Hau C, Miller, Joseph B, Al-Fadhl, Mahmoud D, Thomas, Anthony V, Zackariya, Nuha, Patel, Shivani S, Zackariya, Sufyan, Haidar, Saadeddine, Patel, Bhavesh, McCurdy, Michael T, Thomas, Scott G, Zimmer, Donald, Fulkerson, Daniel, Kim, Paul Y, Walsh, Matthew R, Hake, Daniel, Kedar, Archana, Aboukhaled, Michael, Walsh, Mark M

“…Irrespective of the reason for hypoperfusion, hypocoagulable and/or hyperfibrinolytic hemostatic aberrancies afflict up to one-quarter of critically ill…”
Get full text

Improving acute promyelocytic leukemia (APL) outcome in developing countries through networking, results of the International Consortium on APL by Rego, Eduardo M., Kim, Haesook T., Ruiz-Argüelles, Guillermo J., Undurraga, Maria Soledad, Uriarte, Maria del Rosario, Jacomo, Rafael H., Gutiérrez-Aguirre, Homero, Melo, Raul A.M., Bittencourt, Rosane, Pasquini, Ricardo, Pagnano, Katia, Fagundes, Evandro M., Chauffaille, Maria de Lourdes, Chiattone, Carlos S., Martinez, Lem, Meillón, Luis A., Gómez-Almaguer, David, Kwaan, Hau C., Garcés-Eisele, Javier, Gallagher, Robert, Niemeyer, Charlotte M., Schrier, Stanley L., Tallman, Martin, Grimwade, David, Ganser, Arnold, Berliner, Nancy, Ribeiro, Raul C., Lo-Coco, Francesco, Löwenberg, Bob, Sanz, Miguel A.

“…Thanks to modern treatment with all-trans retinoic acid and chemotherapy, acute promyelocytic leukemia (APL) is now the most curable type of leukemia. However,…”
Get full text

Coronavirus Disease 2019: The Role of the Fibrinolytic System from Transmission to Organ Injury and Sequelae by Kwaan, Hau C

Get more information

Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura by ZHENG, X. Long, WU, Haifeng M, DEZHI SHANG, FALLS, Erica, SKIPWITH, Christopher G, CATALAND, Spero R, BENNETT, Charles L, KWAAN, Hau C

“…Type G immunoglobulins against ADAMTS13 are the primary cause of acquired (idiopathic) thrombotic thrombocytopenic purpura. However, the domains of ADAMTS13…”
Get full text

Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagulation through distinct mechanisms by Budinger, G R Scott, McKell, Joanne L, Urich, Daniela, Foiles, Nancy, Weiss, Ivy, Chiarella, Sergio E, Gonzalez, Angel, Soberanes, Saul, Ghio, Andrew J, Nigdelioglu, Recep, Mutlu, Ece A, Radigan, Kathryn A, Green, David, Kwaan, Hau C, Mutlu, Gökhan M

“…Exposure of human populations to ambient particulate matter (PM) air pollution significantly contributes to the mortality attributable to ischemic…”
Get full text

P2Y12 inhibitor use predicts hematoma expansion in patients with intracerebral hemorrhage by Houskamp, Ethan J., Liu, Yuzhe, Silva Pinheiro do Nascimento, Juliana, Jahromi, Babak S., Lindholm, Paul F., Kwaan, Hau C., Naidech, Andrew M.

“…Objective Hematoma expansion (HE) predicts disability and death after acute intracerebral hemorrhage (ICH). Aspirin and anticoagulants have been associated…”
Get full text

Immuno-Thrombotic Complications of COVID-19: Implications for Timing of Surgery and Anticoagulation by Bunch, Connor M, Moore, Ernest E, Moore, Hunter B, Neal, Matthew D, Thomas, Anthony V, Zackariya, Nuha, Zhao, Jonathan, Zackariya, Sufyan, Brenner, Toby J, Berquist, Margaret, Buckner, Hallie, Wiarda, Grant, Fulkerson, Daniel, Huff, Wei, Kwaan, Hau C, Lankowicz, Genevieve, Laubscher, Gert J, Lourens, Petrus J, Pretorius, Etheresia, Kotze, Maritha J, Moolla, Muhammad S, Sithole, Sithembiso, Maponga, Tongai G, Kell, Douglas B, Fox, Mark D, Gillespie, Laura, Khan, Rashid Z, Mamczak, Christiaan N, March, Robert, Macias, Rachel, Bull, Brian S, Walsh, Mark M

“…Early in the coronavirus disease 2019 (COVID-19) pandemic, global governing bodies prioritized transmissibility-based precautions and hospital capacity as the…”
Get full text

The plasminogen activator system and cancer by McMahon, Brandon, Kwaan, Hau C

“…The fibrinolytic system, more appropriately referred to as the plasminogen activator system, controls not only the intravascular fibrin deposition but also…”
Get more information

Nonhematologic and Hematologic Factors in Spontaneous Intracerebral Hemorrhage by Kwaan, Hau C

“…Spontaneous intracerebral hemorrhage is defined as nontraumatic bleeding into the brain without vascular malformations or presence of tumor. It occurs in about…”
Get more information

Ticlopidine- and clopidogrel-associated thrombotic thrombocytopenic purpura (TTP): review of clinical, laboratory, epidemiological, and pharmacovigilance findings (1989–2008) by Zakarija, Anaadriana, Kwaan, Hau C, Moake, Joel L, Bandarenko, Nicholas, Pandey, Dilip K, McKoy, June M, Yarnold, Paul R, Raisch, Dennis W, Winters, Jeffrey L, Raife, Thomas J, Cursio, John F, Luu, Thanh Ha, Richey, Elizabeth A, Fisher, Matthew J, Ortel, Thomas L, Tallman, Martin S, Zheng, X Long, Matsumoto, Masanori, Fujimura, Yoshihiro, Bennett, Charles L

“…Thrombotic thrombocytopenic purpura (TTP) is a fulminant disease characterized by platelet aggregates, thrombocytopenia, renal insufficiency, neurologic…”
Get full text

Double hazard of thrombophilia and bleeding in leukemia by Kwaan, Hau C

“…The association between thrombosis and cancer has been extensively studied since first pointed out by Trousseau in 1895. It is, however, not commonly…”
Get full text

Ticlopidine‐associated ADAMTS13 activity deficient thrombotic thrombocytopenic purpura in 22 persons in Japan: a report from the Southern Network on Adverse Reactions (SONAR) by Bennett, Charles L., Jacob, Sony, Dunn, Brianne L., Georgantopoulos, Peter, Zheng, X Long, Kwaan, Hau C., McKoy, June M., Magwood, Jametta S., Qureshi, Zaina P., Bandarenko, Nicholas, Winters, Jeffrey L., Raife, Thomas J., Carey, Patricia M., Sarode, Ravindra, Kiss, Joseph E., Danielson, Constance, Ortel, Thomas L., Clark, William F., Ablin, Richard J., Rock, Gail, Matsumoto, Masanori, Fujimura, Yoshihiro

Get full text

A Case Series of Thromboelastography-Guided Anticoagulation in COVID-19 Patients with Inherited and Acquired Hypercoagulable States by Thomas, Anthony V., Lin, Kevin P., Stillson, John E., Bunch, Connor M., Speybroeck, Jacob, Wiarda, Grant, Al-Fadhl, Hamid, Gillespie, Laura, Zamlut, Mahmud, Fulkerson, Daniel H., Khan, Rashid Z., Kwaan, Hau C., Walsh, Mark M.

“…One of the complications of the novel coronavirus disease 2019 (COVID-19) is hypercoagulability. For this reason, patients presenting with COVID-19 are often…”
Get full text