Search Results - "KVEIBORG, Marie"

Loss of ADAM9 expression impairs β1 integrin endocytosis, focal adhesion formation and cancer cell migration by Mygind, Kasper J, Schwarz, Jeanette, Sahgal, Pranshu, Ivaska, Johanna, Kveiborg, Marie

“…The transmembrane protease ADAM9 is frequently upregulated in human cancers, and it promotes tumour progression in mice. , ADAM9 regulates cancer cell adhesion…”
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Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites by Lundby, Alicia, Franciosa, Giulia, Emdal, Kristina B., Refsgaard, Jan C., Gnosa, Sebastian P., Bekker-Jensen, Dorte B., Secher, Anna, Maurya, Svetlana R., Paul, Indranil, Mendez, Blanca L., Kelstrup, Christian D., Francavilla, Chiara, Kveiborg, Marie, Montoya, Guillermo, Jensen, Lars J., Olsen, Jesper V.

“…Tyrosine phosphorylation regulates multi-layered signaling networks with broad implications in (patho)physiology, but high-throughput methods for functional…”
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ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation by Liu, Yawei, Bockermann, Robert, Hadi, Mahdieh, Safari, Iman, Carrion, Belinda, Kveiborg, Marie, Issazadeh-Navikas, Shohreh

“…A disintegrin and metalloproteinase (ADAM)12 was previously found to be expressed in T cells in the inflamed brain. However, the function of ADAM12 in T-cell…”
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ADAM12-Generated Basigin Ectodomain Binds β1 Integrin and Enhances the Expression of Cancer-Related Extracellular Matrix Proteins by Mygind, Kasper J, Nikodemus, Denise, Gnosa, Sebastian, Kweder, Ramya, Albrechtsen, Nicolai J Wewer, Kveiborg, Marie, Erler, Janine T, Albrechtsen, Reidar

“…Desmoplasia is a common feature of aggressive cancers, driven by a complex interplay of protein production and degradation. Basigin is a type 1 integral…”
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Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4 by Lunda, Kathrine, Dmytriyeva, Oksana, Spahr, Louise, Goncalves-Alves, Eliana, Yao, Jiayi, Blasco, Laia P, Trauelsen, Mette, Ponniah, Muthulakshmi, Severin, Marc, Sandelin, Albin, Kveiborg, Marie, Schwartz, Thue W, Pedersen, Stine F

“…Abstract Background The lactate receptor GPR81 contributes to cancer development through unclear mechanisms. Here, we investigate the roles of GPR81 in…”
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Identification of ADAM12 as a Novel Basigin Sheddase by Albrechtsen, Reidar, Albrechtsen, Nicolai J Wewer, Gnosa, Sebastian, Schwarz, Jeanette, Dyrskjøt, Lars, Kveiborg, Marie

“…The transmembrane glycoprotein basigin, a member of the immunoglobulin superfamily, stimulates matrix metalloproteinase (MMP)-mediated extracellular matrix…”
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Sorting nexin 9 (SNX9) regulates levels of the transmembrane ADAM9 at the cell surface by Mygind, Kasper J., Störiko, Theresa, Freiberg, Marie L., Samsøe-Petersen, Jacob, Schwarz, Jeanette, Andersen, Olav M., Kveiborg, Marie

“…ADAM9 is an active member of the family of transmembrane ADAMs (a disintegrin and metalloproteases). It plays a role in processes such as bone formation and…”
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PKCα and PKCδ regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways by Kveiborg, Marie, Instrell, Rachael, Rowlands, Christina, Howell, Michael, Parker, Peter J

“…Epidermal growth factor receptor (EGFR) signalling is initiated by the release of EGFR-ligands from membrane-anchored precursors, a process termed ectodomain…”
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ADAM17-mediated EGFR ligand shedding directs macrophage-promoted cancer cell invasion by Gnosa, Sebastian P., Puig Blasco, Laia, Piotrowski, Krzysztof B., Freiberg, Marie L., Savickas, Simonas, Madsen, Daniel H., auf dem Keller, Ulrich, Kronqvist, Pauliina, Kveiborg, Marie

“…Macrophages in the tumor microenvironment have a substantial impact on tumor progression. Depending on the signaling environment in the tumor, macrophages can…”
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ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression by Fröhlich, Camilla, Nehammer, Camilla, Albrechtsen, Reidar, Kronqvist, Pauliina, Kveiborg, Marie, Sehara-Fujisawa, Atsuko, Mercurio, Arthur M, Wewer, Ulla M

“…Expression of ADAM12 is low in most normal tissues but is markedly increased in numerous human cancers, including breast carcinomas. We have previously shown…”
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Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2) by Kveiborg, Marie, Jacobsen, Jonas, Lee, Meng-Huee, Nagase, Hideaki, Wewer, Ulla M, Murphy, Gillian

“…The disintegrin and metalloprotease ADAM12 has important functions in normal physiology as well as in diseases, such as cancer. Little is known about how…”
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Functional analysis of a breast cancer-associated mutation in the intracellular domain of the metalloprotease ADAM12 by Stautz, Dorte, Wewer, Ulla M, Kveiborg, Marie

“…A recently identified breast cancer-associated mutation in the metalloprotease ADAM12 alters a potential dileucine trafficking signal, which could affect…”
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A role for ADAM12 in breast tumor progression and stromal cell apoptosis by KVEIBORG, Marie, FRÖHLICH, Camilla, ALBRECHTSEN, Reidar, TISCHLER, Verena, DIETRICH, Nikolaj, HOLCK, Peter, KRONQVIST, Pauliina, RANK, Fritz, MERCURIO, Arthur M, WEWER, Ulla M

“…As in developmental and regenerative processes, cell survival is of fundamental importance in cancer. Thus, a tremendous effort has been devoted to dissecting…”
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ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating β1 integrin function by Kawaguchi, Nobuko, Sundberg, Christina, Kveiborg, Marie, Moghadaszadeh, Behzad, Asmar, Meena, Dietrich, Nikolaj, Thodeti, Charles K., Nielsen, Finn C., Möller, Peter, Mercurio, Arthur M., Albrechtsen, Reidar, Wewer, Ulla M.

“…Changes in cell shape are a morphological hallmark of differentiation. In this study we report that the expression of ADAM12, a disintegrin and…”
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Energy expenditure and bone formation share a common sensitivity to AP-1 transcription in the hypothalamus by Rowe, Glenn C, Vialou, Vincent, Sato, Kazusa, Saito, Hiroaki, Yin, Min, Green, Thomas A, Lotinun, Sutada, Kveiborg, Marie, Horne, William C, Nestler, Eric J, Baron, Roland

“…The regulation of bone and fat homeostasis and its relationship to energy expenditure has recently been the focus of increased attention because of its…”
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Doubly Truncated FosB Isoform (Δ2ΔFosB) Induces Osteosclerosis in Transgenic Mice and Modulates Expression and Phosphorylation of Smads in Osteoblasts Independent of Intrinsic AP‐1 Activity by Sabatakos, George, Rowe, Glenn C, Kveiborg, Marie, Wu, Meilin, Neff, Lynn, Chiusaroli, Riccardo, Philbrick, William M, Baron, Roland

“…Introduction: Activator protein (AP)‐1 family members play important roles in the development and maintenance of the adult skeleton. Transgenic mice that…”
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ΔFosB Induces Osteosclerosis and Decreases Adipogenesis by Two Independent Cell-Autonomous Mechanisms by Kveiborg, Marie, Sabatakos, George, Chiusaroli, Riccardo, Wu, Meilin, Philbrick, William M., Horne, William C., Baron, Roland

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Hierarchy of ADAM12 binding to integrins in tumor cells by Thodeti, Charles Kumar, Fröhlich, Camilla, Nielsen, Christian Kamp, Holck, Peter, Sundberg, Christina, Kveiborg, Marie, Mahalingam, Yashithra, Albrechtsen, Reidar, Couchman, John R., Wewer, Ulla M.

“…ADAMs (a disintegrin and metalloprotease) comprise a family of cell surface proteins with protease and cell-binding activities. Using different forms and…”
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PACS-2 functions in colorectal cancer by Kveiborg, Marie, Thomas, Gary

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ADAM12 Is a Four-leafed Clover by Wewer, Ulla M., Mörgelin, Matthias, Holck, Peter, Jacobsen, Jonas, Lydolph, Magnus C., Johnsen, Anders H., Kveiborg, Marie, Albrechtsen, Reidar

“…The ADAMs (adisintegrin and metalloprotease) comprise a family of multidomain proteins with metalloprotease, cell adhesion, and signaling activities. Human…”
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